{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:20:10Z","timestamp":1773872410124,"version":"3.50.1"},"reference-count":41,"publisher":"The Royal Society","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"crossref","award":["Campania OncoTerapie, POR CAMPANIA FESR 2014\/2020"],"award-info":[{"award-number":["Campania OncoTerapie, POR CAMPANIA FESR 2014\/2020"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"crossref","award":["GENOBU, PON01_00486"],"award-info":[{"award-number":["GENOBU, PON01_00486"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Open Biol."],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>\n                    Chronic\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection is the leading cause of intestinal-type adenocarcinoma, as prolonged\n                    <jats:italic>Helicobacter<\/jats:italic>\n                    colonization triggers chronic active gastritis, which may evolve into adenocarcinoma of the intestinal type. In this environment, cytokines play a significant role in determining the evolution of the infection. In combination with other factors (genetic, environmental and nutritional), the pro-inflammatory response may trigger pro-oncogenic mechanisms that lead to the silencing of tumour-suppressor genes, such as trefoil factor 1 (TFF1). The latter is known to play a protective role by maintaining the gastric mucosa integrity and retaining\n                    <jats:italic>H. pylori<\/jats:italic>\n                    in the mucus layer, preventing the progression of infection and, consequently, the development of gastric cancer (GC). Since TFF1 expression is reduced during chronic\n                    <jats:italic>Helicobacter<\/jats:italic>\n                    infection with a loss of gastric mucosa protection, we investigated the molecular pathways involved in this reduction. Specifically, we evaluated the effect of some pro-inflammatory cytokines on TFF1 regulation in GC and primary gastric cells by RT-qPCR and luciferase reporter assay analyses and the repressor role of the transcription factor C\/EBP\u03b2, overexpressed in gastric-intestinal cancer. Our results show that, among several cytokines, IFN\u03b3 stimulates C\/EBP\u03b2 expression, which acts as a negative regulator of TFF1 by binding its promoter at three different sites.\n                  <\/jats:p>","DOI":"10.1098\/rsob.220278","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T04:08:12Z","timestamp":1670990892000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["IFN\u03b3-dependent silencing of TFF1 during\n                    <i>Helicobacter pylori<\/i>\n                    infection"],"prefix":"10.1098","volume":"12","author":[{"given":"D.","family":"Eletto","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Mentucci","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy"},{"name":"PhD Program in Drug Discovery and Development, University of Salerno, Fisciano, Salerno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Vllahu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Voli","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy"},{"name":"PhD Program in Drug Discovery and Development, University of Salerno, Fisciano, Salerno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Petrella","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Boccellato","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. F.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany"},{"name":"Laboratory of Infection Oncology, Institute of Clinical Molecular Biology, Christian Albrecht's University of Kiel\u2014University Hospital Schleswig Holstein\u2014Campus Kiel, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Porta","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5443-1565","authenticated-orcid":true,"given":"A.","family":"Tosco","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-1057"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.10.019"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073531"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.4.1755-1762.2003"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/315957"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.12.5964-5971.1998"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.12.1473"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.2.133"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.2217\/fon.10.37"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00047"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5285.259"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000029205.76632.A8"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520701579795"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00434"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021115-105447"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314540"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079455"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsim.2004.10.013"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010047200"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.44.28545"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-016-1447-7"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbaexp.2004.12.014"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000066279"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2002.01014.x"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308489101"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041851"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0309-7"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.11.014"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15188"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02140-2"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30111"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.1.279-285.1999"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.047"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803293"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29176-w"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.12.008"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00293.2002"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.11.037"},{"key":"e_1_3_6_42_2","doi-asserted-by":"crossref","unstructured":"Eletto D Mentucci F Vllahu M Voli A Petrella A Boccellato F Meyer TF Porta A Tosco A. 2022 IFN\u03b3-dependent silencing of TFF1 during Helicobacter pylori infection. 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