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Among them, the type 3 secretion system-1 (T3SS-1) and the Rck and PagN invasins are involved in the internalization of the pathogen within eukaryotic cells, but their precise role in the host and in the pathogenic process is still poorly understood. In this study, we aimed to determine the kinetics of expression of these entry factors in a typhoid fever-like and a gastroenteritis model in mice by in vivo imaging using bioluminescent Salmonella Typhimurium reporter strains carrying chromosomal transcriptional fusions. Only pagN and T3SS-1 transcription has been clearly identified. Independently of the pathological model, the caecum was identified as the main transcription site of both pagN and the T3SS-1-encoding gene both at early and late stages of the infection. An intense transcription of pagN was also observed in deep organs in the typhoid fever-like model, while that of T3SS-1 remained quite sporadic in these organs, and mainly focused on the intestine all along the infection. This work will help to understand the respective role of these entry factors at the cellular level in the pathogenesis of Salmonella in vivo.<\/jats:p>","DOI":"10.1098\/rsob.230312","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T19:05:10Z","timestamp":1705431910000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["From intestine to beyond:\n                    <i>Salmonella<\/i>\n                    entry factors display distinct transcription pattern upon infection in murine models"],"prefix":"10.1098","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5191-7853","authenticated-orcid":false,"given":"Micha\u00ebl","family":"Koczerka","sequence":"first","affiliation":[{"name":"37380, Nouzilly, France","department":["INRAE, Universit\u00e9 de Tours, ISP,"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1250-767X","authenticated-orcid":false,"given":"Isabelle","family":"Lantier","sequence":"additional","affiliation":[{"name":"37380, Nouzilly, France","department":["INRAE, Universit\u00e9 de Tours, ISP,"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Morillon","sequence":"additional","affiliation":[{"name":"37380, Nouzilly, France","department":["INRAE, Universit\u00e9 de Tours, ISP,"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0685-6508","authenticated-orcid":false,"given":"Justine","family":"Deperne","sequence":"additional","affiliation":[{"name":"37380, Nouzilly, France","department":["INRAE, Universit\u00e9 de Tours, ISP,"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1247-3360","authenticated-orcid":false,"given":"Camille D.","family":"Clamagirand","sequence":"additional","affiliation":[{"name":"37380, Nouzilly, France","department":["INRAE, Universit\u00e9 de Tours, ISP,"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4149-0168","authenticated-orcid":true,"given":"Isabelle","family":"Virlogeux-Payant","sequence":"additional","affiliation":[{"name":"37380, Nouzilly, France","department":["INRAE, Universit\u00e9 de Tours, ISP,"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5085-474X","authenticated-orcid":true,"given":"Olivier","family":"Gr\u00e9pinet","sequence":"additional","affiliation":[{"name":"37380, Nouzilly, France","department":["INRAE, Universit\u00e9 de Tours, ISP,"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"2026010717003183000_RSOB230312C1","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/S1473-3099(19)30418-9","article-title":"The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017","volume":"19","author":"Stanaway","year":"2019","journal-title":"Lancet Infect. 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