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One mechanism that causes the failure of\n                    <jats:italic>Candida<\/jats:italic>\n                    eradication is an increase in regulatory T cells (Treg), which play a major role in immune suppression and promoting\n                    <jats:italic>Candida<\/jats:italic>\n                    pathogenicity. To date, how\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    induces a Treg response remains unclear. Dendritic cells (DCs) recognition of fungi provides the fundamental signal determining the fate of the T-cell response. This study investigated the interplay between\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    and DCs and its effect on Treg induction. We found that\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    \u03b2-glucan was a major component that interacted with DCs and consequently mediated the Treg response. Blocking the binding of\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    \u03b2-glucan to dectin-1 and complement receptor 3 (CR3) showed that CR3 activation in DCs was crucial for the induction of Treg. Furthermore, a ligand\u2013receptor binding assay showed the preferential binding of\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    \u03b2-glucan to CR3. Our data suggest that\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    \u03b2-glucan potentially mediates the Treg response, probably through CR3-dependent activation in DCs. This study contributes new insights into immune modulation by\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    that may lead to a better design of novel immunotherapeutic strategies for invasive\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1098\/rsob.230315","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T19:05:12Z","timestamp":1716923112000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Complement receptor 3-dependent engagement by\n                    <i>Candida glabrata<\/i>\n                    \u03b2-glucan modulates dendritic cells to induce regulatory T-cell expansion"],"prefix":"10.1098","volume":"14","author":[{"given":"Areerat","family":"Kunanopparat","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Dentistry, 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