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Given the common hallmark of altered miRNA expression profiles in haematological malignancies and the pro-leukaemic role of GATA-1\n                    <jats:sub>S<\/jats:sub>\n                    , we aimed to search for miRNAs potentially able to modulate the expression of GATA-1 isoforms. Starting from an\n                    <jats:italic>in silico<\/jats:italic>\n                    prediction of miRNA binding sites in the GATA-1 transcript, miR-1202 came into our sight as potential regulator of GATA-1 expression. Expression studies in K562 cells revealed that miR-1202 directly targets GATA-1, negatively regulates its expression, impairs GATA-1\n                    <jats:sub>S<\/jats:sub>\n                    production, reduces cell proliferation, and increases apoptosis sensitivity. Furthermore, data from TAM and myeloid leukaemia patients provided substantial support to our study by showing that miR-1202 down-modulation is accompanied by increased GATA-1 levels, with more marked effects on GATA-1\n                    <jats:sub>S<\/jats:sub>\n                    . These findings indicate that miR-1202 acts as an anti-oncomiR in myeloid cells and may impact leukaemogenesis at least in part by down-modulating GATA-1\n                    <jats:sub>S<\/jats:sub>\n                    levels.\n                  <\/jats:p>","DOI":"10.1098\/rsob.230319","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T19:05:14Z","timestamp":1707851114000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["miR-1202 acts as anti-oncomiR in myeloid leukaemia by down-modulating GATA-1\n                    <sub>S<\/sub>\n                    expression"],"prefix":"10.1098","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4835-357X","authenticated-orcid":true,"given":"Raffaele","family":"Sessa","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, 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