{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:51:53Z","timestamp":1787068313554,"version":"build-2736575974"},"reference-count":46,"publisher":"The Royal Society","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Open Biol."],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>\n                    Osteopontin (OPN) is a pro-inflammatory protein that influences bone remodelling, wound healing, angiogenesis, allergic inflammation, and skin diseases such as psoriasis, contact dermatitis and skin cancer. However, the role of OPN in the skin remains unclear. Therefore, this study aimed to investigate the role of OPN in the skin, particularly in the context of ultraviolet (UV) irradiation-induced inflammation. OPN expression and its effects on inflammatory modulators were assessed in human skin, in a mouse model and\n                    <jats:italic>in vitro<\/jats:italic>\n                    , using a UV source emitting both UVB and UVA radiation, which collectively contribute to UV-induced skin inflammation. OPN expression increased in human and mouse skin after UV irradiation. Compared with wild-type mice, UV irradiation-induced skin phenotypes, such as erythema and skin thickening, were alleviated in OPN\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. In addition, the number of immune cells recruited to the skin after UV irradiation and the expression of inflammatory cytokines and matrix metalloproteinases (MMPs) were observed to be decreased in the skin of OPN\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice compared with that of wild-type mice. By contrast, the degree of skin inflammation was higher in the hOPN KI mice than in wild-type mice. Treatment with recombinant OPN increased the expression of MMP-1 and inflammatory cytokines in human dermal fibroblasts and epidermal keratinocytes\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Our results suggest that OPN may play a regulatory role in UV-induced skin inflammation.\n                  <\/jats:p>","DOI":"10.1098\/rsob.230397","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T05:41:09Z","timestamp":1731476469000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The pivotal role of osteopontin in UV-induced skin inflammation in a mouse model"],"prefix":"10.1098","volume":"14","author":[{"given":"Haesoo","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea"},{"name":"Institute of Human-Environmental Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Yup","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea"},{"name":"Institute of Human-Environmental Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea"},{"name":"Institute of Human-Environmental Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea"},{"name":"Institute of Human-Environmental Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Hyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea"},{"name":"Institute of Human-Environmental Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0582-6392","authenticated-orcid":true,"given":"Jin Ho","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea"},{"name":"Institute of Human-Environmental Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea"},{"name":"Institute on Aging, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1993.21"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140612222"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.06.015"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00008.2011"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.07.004"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/10454411000110030101"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5454.860"},{"key":"e_1_3_8_9_2","first-page":"206","article-title":"Differentiation, maturation, and survival of dendritic cells by osteopontin regulation","volume":"12","author":"Kawamura K","year":"2005","unstructured":"Kawamura K, Iyonaga K, Ichiyasu H, Nagano J, Suga M, Sasaki Y. 2005 Differentiation, maturation, and survival of dendritic cells by osteopontin regulation. 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