{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:14:11Z","timestamp":1790745251982,"version":"4.1.0"},"reference-count":68,"publisher":"The Royal Society","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Open Biol."],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n                    Succinate dehydrogenase (SDH) is a protein complex that functions in the tricarboxylic acid cycle and the electron transport chain of mitochondria. In most eukaryotes, SDH is highly conserved and comprises the following four subunits: SdhA and SdhB form the catalytic core of the complex, while SdhC and SdhD anchor the complex in the membrane.\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    is an apicomplexan parasite that infects one-third of humans worldwide. The genome of\n                    <jats:italic>T. gondii<\/jats:italic>\n                    encodes homologues of the catalytic subunits SdhA and SdhB, although the physiological role of the SDH complex in the parasite and the identity of the membrane-anchoring subunits are poorly understood. Here, we show that the SDH complex contributes to optimal proliferation and O\n                    <jats:sub>2<\/jats:sub>\n                    consumption in the disease-causing tachyzoite stage of the\n                    <jats:italic>T. gondii<\/jats:italic>\n                    life cycle. We characterize a small membrane-bound subunit of the SDH complex called mitochondrial protein ookinete developmental defect (MPODD), which is conserved among myzozoans, a phylogenetic grouping that incorporates apicomplexan parasites and their closest free-living relatives. We demonstrate that\n                    <jats:italic>Tg<\/jats:italic>\n                    MPODD is essential for SDH activity and plays a key role in attaching the\n                    <jats:italic>Tg<\/jats:italic>\n                    SdhA and\n                    <jats:italic>Tg<\/jats:italic>\n                    SdhB proteins to the membrane anchor of the complex. Our findings highlight a unique and important feature of mitochondrial energy metabolism in apicomplexan parasites and their relatives.\n                  <\/jats:p>","DOI":"10.1098\/rsob.230463","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T03:09:20Z","timestamp":1717556960000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["A myzozoan-specific protein is an essential membrane-anchoring component of the succinate dehydrogenase complex in\n                    <i>Toxoplasma<\/i>\n                    parasites"],"prefix":"10.1098","volume":"14","author":[{"given":"Soraya M.","family":"Zwahlen","sequence":"first","affiliation":[{"name":"Research School of Biology, Australian National University","place":["Canberra, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenni A.","family":"Hayward","sequence":"additional","affiliation":[{"name":"Research School of Biology, Australian National University","place":["Canberra, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Capella S.","family":"Maguire","sequence":"additional","affiliation":[{"name":"Research School of Biology, Australian National University","place":["Canberra, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex R.","family":"Qin","sequence":"additional","affiliation":[{"name":"Research School of Biology, Australian National University","place":["Canberra, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2455-9821","authenticated-orcid":true,"given":"Giel G.","family":"van Dooren","sequence":"additional","affiliation":[{"name":"Research School of Biology, Australian National University","place":["Canberra, 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