{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:29:37Z","timestamp":1789586977713,"version":"build-2803163510"},"reference-count":62,"publisher":"The Royal Society","issue":"7","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Novo Nordisk Fonden Laureate award"},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Open Biol."],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    O-GlcNAcylation of intracellular proteins is a key regulator of diverse cellular and developmental processes. Previous studies have demonstrated the acute sensitivity of cell cycle progression to chemical and genetic manipulation of O-GlcNAc homeostasis. However, the mechanisms by which O-GlcNAc regulates the cell cycle remain poorly understood. Here, we report Ser584 O-GlcNAcylation of the RNA helicase DDX3X, a microcephaly associated protein, as a proteostatic mechanism regulating S-phase entry. Loss of Ser584 O-GlcNAcylation promoted degradation of DDX3X by the proteasome, resulting in reduced expression of the DDX3X target gene\n                    <jats:italic toggle=\"yes\">cyclin E1<\/jats:italic>\n                    and impaired cell cycle progression from G1 to S phase. These findings display how a single O-GlcNAc site affects DDX3X stability and thereby the cell cycle.\n                  <\/jats:p>","DOI":"10.1098\/rsob.250064","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T19:07:46Z","timestamp":1751396866000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["O-GlcNAcylation of the intellectual disability protein DDX3X exerts proteostatic cell cycle control"],"prefix":"10.1098","volume":"15","author":[{"given":"Conor W.","family":"Mitchell","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Aarhus Universitet","place":["Aarhus, Denmark"]},{"name":"Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK","place":["Dundee, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Aarhus Universitet","place":["Aarhus, Denmark"]},{"name":"Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK","place":["Dundee, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"S\u00f8nderstrup-Jensen","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Aarhus Universitet","place":["Aarhus, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Ferenbach","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Aarhus Universitet","place":["Aarhus, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1499-6908","authenticated-orcid":true,"given":"Daan M. 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