{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:07:47Z","timestamp":1780078067068,"version":"3.54.0"},"reference-count":56,"publisher":"The Royal Society","issue":"3","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Breast Cancer Now"},{"DOI":"10.13039\/501100022850","name":"Little Princess Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100022850","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013267","name":"Kidscan Children's Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013267","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cellular myelocytomatosis oncogene (MYC) transcription factors are encoded by a family of genes that include the prototype member MYC, MYCN and MYCL, and most human cancers display expression alterations of MYC genes. MYC is regulated at multiple levels, and its stability and activity are modulated by protein phosphorylation. Although there is a reasonable knowledge of the kinases required for MYC modifications, the counteracting phosphatases have been understudied. Here, we have investigated the role of the chromatin-associated protein phosphatase 1 (PP1) regulatory subunit CDCA2, also known as Repo-Man, in the regulation of MYC proteins in cancer cells. Using RNA interference and degron-mediated degradation of CDCA2, we have demonstrated that the PP1 subunit is required for cMYC and MYCN stabilization and viability of triple-negative breast cancer, neuroblastoma and colon cancer cells. Proximity ligation assays indicate that both cMYC and MYCN are in close proximity to CDCA2 in vivo. Furthermore, we have shown that CDC2A is a bona fide MYC target gene in cancer cells, revealing a reciprocal regulatory loop that could be exploited for therapeutic purposes.<\/jats:p>","DOI":"10.1098\/rsob.250075","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:14:22Z","timestamp":1773792862000},"source":"Crossref","is-referenced-by-count":0,"title":["A CDCA2\u2013MYC positive feedback loop controls cancer cells survival"],"prefix":"10.1098","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5650-078X","authenticated-orcid":false,"given":"Konstantinos","family":"Stamatiou","sequence":"first","affiliation":[{"name":"Brunel University of London 1 , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Ligammari","sequence":"additional","affiliation":[{"name":"Brunel University of London 1 , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malki","family":"Bothota","sequence":"additional","affiliation":[{"name":"Brunel University of London 1 , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Tsavou","sequence":"additional","affiliation":[{"name":"Brunel University of London 1 , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezgi","family":"Gokhan","sequence":"additional","affiliation":[{"name":"Brunel University of London 1 , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylenia","family":"Cicir\u00f2","sequence":"additional","affiliation":[{"name":"Brunel University of London 1 , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano F.","family":"Zacar\u00edas-Fluck","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Institute of Oncology, Cellex Centre, Hospital University Vall d\u2019Hebron Campus 2 , ,","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Soucek","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Institute of Oncology, Cellex Centre, Hospital University Vall d\u2019Hebron Campus 2 , ,","place":["Barcelona, Spain"]},{"name":"Institucio\u0301 Catalana de Recerca i Estudis Avanc\u0327ats 3 , ,","place":["Barcelona, Spain"]},{"name":"Universitat Autonoma de Barcelona 4 , ,","place":["Bellaterra, Spain"],"department":["Department of Biochemistry and Molecular Biology"]},{"name":"Peptomyc S.L. 5 , ,","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2841-7866","authenticated-orcid":false,"given":"Arturo","family":"Sala","sequence":"additional","affiliation":[{"name":"Brunel University of London 1 , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0000-2271","authenticated-orcid":false,"given":"Paola","family":"Vagnarelli","sequence":"additional","affiliation":[{"name":"Brunel University of London 1 , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"2026052913314993900_R1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1342872","article-title":"MYC: there is more to it than cancer","volume":"12","author":"Zacar\u00edas-Fluck","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"2026052913314993900_R2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.bbagrm.2014.05.016","article-title":"Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis","volume":"1849","author":"Diolaiti","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"2026052913314993900_R3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41580-020-0215-2","article-title":"Target gene-independent functions of MYC oncoproteins","volume":"21","author":"Baluapuri","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026052913314993900_R4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41388-024-03174-2","article-title":"Transcriptional regulation by MYC: an emerging new model","volume":"44","author":"Jakobsen","year":"2025","journal-title":"Oncogene"},{"key":"2026052913314993900_R5","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a014191","article-title":"Genome recognition by MYC","volume":"4","author":"Sab\u00f2","year":"2014","journal-title":"Cold Spring Harb. Perspect. 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Sci."},{"key":"2026052913314993900_R8","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ccell.2020.01.001","article-title":"Direct phosphorylation and stabilization of MYC by aurora B kinase promote T-cell leukemogenesis","volume":"37","author":"Jiang","year":"2020","journal-title":"Cancer Cell"},{"key":"2026052913314993900_R9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1073\/pnas.0900121106","article-title":"Phosphorylation by Cdk2 is required for Myc to repress ras-induced senescence in cotransformation","volume":"107","author":"Hydbring","year":"2010","journal-title":"Proc. Natl Acad. Sci. 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Clin. Pathol."},{"key":"2026052913314993900_R17","article-title":"A pan-cancer analysis reveals the diagnostic and prognostic role of CDCA2 in low-grade glioma","volume":"18","author":"Li","year":"2023","journal-title":"PLoS One"},{"key":"2026052913314993900_R18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejca.2023.04.005","article-title":"CDCA2 promotes melanoma progression by inhibiting ubiquitin-mediated degradation of Aurora kinase A","volume":"188","author":"Sun","year":"2023","journal-title":"Eur. J. Cancer"},{"key":"2026052913314993900_R19","article-title":"Increased CDCA2 level was related to poor prognosis in hepatocellular carcinoma and associated with up-regulation of immune checkpoints","volume":"8","author":"Tang","year":"2021","journal-title":"Front. 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Biol."},{"key":"2026052913314993900_R37","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1038\/s41467-020-14743-w","article-title":"An integrative ENCODE resource for cancer genomics","volume":"11","author":"Zhang","year":"2020","journal-title":"Nat. Commun."},{"key":"2026052913314993900_R38","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040883","article-title":"Blocking Myc to treat cancer: reflecting on two decades of omomyc","volume":"9","author":"Mass\u00f3-Vall\u00e9s","year":"2020","journal-title":"Cells"},{"key":"2026052913314993900_R39","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/s41591-024-02805-1","article-title":"MYC targeting by OMO-103 in solid tumors: a phase 1 trial","volume":"30","author":"Garralda","year":"2024","journal-title":"Nat. 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Figshare.","author":"Stamatiou","year":"2026"}],"container-title":["Open Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/rsob\/article-pdf\/doi\/10.1098\/rsob.250075\/6125486\/rsob.250075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rsob\/article-pdf\/doi\/10.1098\/rsob.250075\/6125486\/rsob.250075.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:32:06Z","timestamp":1780075926000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rsob\/article\/16\/3\/250075\/480941\/A-CDCA2-MYC-positive-feedback-loop-controls-cancer"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,11]]}},"URL":"https:\/\/doi.org\/10.1098\/rsob.250075","relation":{"has-review":[{"id-type":"doi","id":"10.1098\/RSOB.250075\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.250075\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.250075\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.250075\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.250075\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.250075\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.250075\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.250075\/v2\/response1","asserted-by":"object"}]},"ISSN":["2046-2441"],"issn-type":[{"value":"2046-2441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,11]]},"article-number":"250075"}}