{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T01:33:52Z","timestamp":1772156032741,"version":"3.50.1"},"reference-count":54,"publisher":"The Royal Society","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rowden White Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endometrial receptivity occurs during a limited time in the menstrual cycle called the \u2018window of implantation\u2019 (WOI) and is required for successful implantation. Endometrial luminal epithelial cells become adhesive to facilitate embryo attachment and implantation; however, how this occurs is poorly understood. We recently identified that myosin heavy chain 10 (MYH10) was abnormally downregulated in infertile organoid endometrial epithelial cells during the WOI, suggesting a role in receptivity. MYH10 regulates cell polarity, adhesion and migration; however, whether it regulates receptivity is unknown. Our research investigated whether MYH10 regulates endometrial epithelial cell adhesive capacity. MYH10 is localized to all major cellular compartments within the endometrium. Immunostaining intensity was higher in luminal epithelial cells during the WOI compared to the proliferative phase in fertile endometrium. However, MYH10 staining was decreased in infertile endometrium. siRNA knockdown of MYH10 in the Ishikawa cell line significantly decreased cell adhesion to human cytotrophoblast-progenitor spheroids. MYH10 knockdown increased PGR and FOXO1 while decreasing PDLIM2 expression. Proteomics analysis following MYH10 knockdown demonstrated altered production of 57 proteins with functions critical in receptivity, including tight junctions. These results demonstrate that MYH10 alters endometrial epithelial cell adhesive capacity primarily via regulation of the actin cytoskeleton, implying an important role in implantation.<\/jats:p>","DOI":"10.1098\/rsob.250105","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T01:43:26Z","timestamp":1768959806000},"source":"Crossref","is-referenced-by-count":0,"title":["Myosin heavy chain 10 dysregulation in infertile endometrial epithelial cells impairs adhesive capacity"],"prefix":"10.1098","volume":"16","author":[{"given":"Michaela","family":"Sacco","sequence":"first","affiliation":[{"name":"The University of Melbourne 1 , , ,","place":["Melbourne, Victoria, Australia"],"department":["Department of Obstetrics, Gynaecology and Newborn Health"]},{"name":"The Royal Women\u2019s Hospital 2 , , ,","place":["Parkville, Victoria, Australia"],"department":["Gynaecology Research Centre"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poppy","family":"Downing","sequence":"additional","affiliation":[{"name":"The University of Melbourne 1 , , ,","place":["Melbourne, Victoria, Australia"],"department":["Department of Obstetrics, Gynaecology and Newborn Health"]},{"name":"The Royal Women\u2019s Hospital 2 , , ,","place":["Parkville, Victoria, Australia"],"department":["Gynaecology Research Centre"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leilani L.","family":"Santos","sequence":"additional","affiliation":[{"name":"The University of Melbourne 1 , , ,","place":["Melbourne, Victoria, Australia"],"department":["Department of Obstetrics, Gynaecology and Newborn Health"]},{"name":"The Royal Women\u2019s Hospital 2 , , ,","place":["Parkville, Victoria, Australia"],"department":["Gynaecology Research Centre"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Varshney","sequence":"additional","affiliation":[{"name":"Bio21 Molecular Science and Biotechnology Institute 3 , , ,","place":["Parkville, Victoria, Australia"],"department":["Melbourne Mass Spectrometry and Proteomics Facility"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan Tinn","family":"Teh","sequence":"additional","affiliation":[{"name":"The University of Melbourne 1 , , ,","place":["Melbourne, Victoria, Australia"],"department":["Department of Obstetrics, Gynaecology and Newborn Health"]},{"name":"The Royal Women\u2019s Hospital 4 , , ,","place":["Parkville, Victoria, Australia"]},{"name":"Melbourne IVF 5 , , ,","place":["Melbourne, Victoria, Australia"]},{"name":"Epworth HealthCare 6 , , ,","place":["Melbourne, Victoria, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9636-7963","authenticated-orcid":false,"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"The University of Melbourne 1 , , ,","place":["Melbourne, Victoria, Australia"],"department":["Department of Obstetrics, Gynaecology and Newborn Health"]},{"name":"The Royal Women\u2019s Hospital 2 , , ,","place":["Parkville, Victoria, Australia"],"department":["Gynaecology Research Centre"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-950X","authenticated-orcid":false,"given":"Evdokia","family":"Dimitriadis","sequence":"additional","affiliation":[{"name":"The University of Melbourne 1 , , ,","place":["Melbourne, Victoria, Australia"],"department":["Department of Obstetrics, Gynaecology and Newborn Health"]},{"name":"The Royal Women\u2019s Hospital 2 , , ,","place":["Parkville, Victoria, Australia"],"department":["Gynaecology Research Centre"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"2026012020432089200_R1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41572-020-00228-z","article-title":"Recurrent pregnancy loss","volume":"6","author":"Dimitriadis","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2026012020432089200_R2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.fertnstert.2019.02.009","article-title":"What exactly is endometrial receptivity?","volume":"111","author":"Lessey","year":"2019","journal-title":"Fertil. Steril."},{"key":"2026012020432089200_R3","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.596324","article-title":"Alterations in epithelial cell polarity during endometrial receptivity: a systematic review","volume":"11","author":"Whitby","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"2026012020432089200_R4","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1210\/en.2017-03082","article-title":"Embryo implantation: war in times of love","volume":"159","author":"Ashary","year":"2018","journal-title":"Endocrinology"},{"key":"2026012020432089200_R5","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/humupd\/dmy044","article-title":"Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis","volume":"25","author":"Craciunas","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"2026012020432089200_R6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41746-023-00848-1","article-title":"Menstrual cycle length variation by demographic characteristics from the Apple Women\u2019s Health Study","volume":"6","author":"Li","year":"2023","journal-title":"NPJ Digit. Med."},{"key":"2026012020432089200_R7","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13072145","article-title":"The contribution of proteomics in understanding endometrial protein expression in women with recurrent implantation failure","volume":"13","author":"Potiris","year":"2024","journal-title":"J. Clin. Med."},{"key":"2026012020432089200_R8","doi-asserted-by":"crossref","DOI":"10.1080\/09513590.2023.2217261","article-title":"Recurrent implantation failure versus recurrent implantation success: a preliminary study at proteomic level","volume":"39","author":"Zhao","year":"2023","journal-title":"Gynecol. Endocrinol."},{"key":"2026012020432089200_R9","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201900250","article-title":"Proteomic insights into endometrial receptivity and embryo\u2013endometrial epithelium interaction for implantation reveal critical determinants of fertility","volume":"20","author":"Evans","year":"2020","journal-title":"Proteomics"},{"key":"2026012020432089200_R10","article-title":"Screening and identification of endometrial proteins as novel potential biomarkers for repeated implantation failure","volume":"9","author":"Wang","year":"2021","journal-title":"PeerJ"},{"key":"2026012020432089200_R11","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.202000211","article-title":"Proteomic profiling of human uterine extracellular vesicles reveal dynamic regulation of key players of embryo implantation and fertility during menstrual cycle","volume":"21","author":"Rai","year":"2021","journal-title":"Proteomics"},{"key":"2026012020432089200_R12","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.fertnstert.2012.09.013","article-title":"Proteomics of the human endometrium and uterine fluid: a pathway to biomarker discovery","volume":"99","author":"Salamonsen","year":"2013","journal-title":"Fertil. Steril."},{"key":"2026012020432089200_R13","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1067648","article-title":"Infertile human endometrial organoid apical protein secretions are dysregulated and impair trophoblast progenitor cell adhesion","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Endocrinol."},{"key":"2026012020432089200_R14","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nrm2786","article-title":"Non-muscle myosin II takes centre stage in cell adhesion and migration","volume":"10","author":"Vicente-Manzanares","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026012020432089200_R15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0167-4889(00)00005-7","article-title":"Myosins: a diverse superfamily","volume":"1496","author":"Sellers","year":"2000","journal-title":"Biochim. Et Biophys. Acta"},{"key":"2026012020432089200_R16","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-019-0336-3","article-title":"Mesenchymal actomyosin contractility is required for androgen-driven urethral masculinization in mice","volume":"2","author":"Acebedo","year":"2019","journal-title":"Commun. Biol."},{"key":"2026012020432089200_R17","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nrm4012","article-title":"Forcing cells into shape: the mechanics of actomyosin contractility","volume":"16","author":"Murrell","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026012020432089200_R18","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/molehr\/3.4.275","article-title":"Adhesiveness of the free surface of a human endometrial monolayer for trophoblast as related to actin cytoskeleton","volume":"3","author":"Thie","year":"1997","journal-title":"Mol. Hum. Reprod."},{"key":"2026012020432089200_R19","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/humrep\/14.2.515","article-title":"Presence of uterine pinopodes at the embryo-endometrial interface during human implantation in vitro","volume":"14","author":"Bentin-Ley","year":"1999","journal-title":"Hum. Reprod."},{"key":"2026012020432089200_R20","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a018267","article-title":"The actin cytoskeleton and actin-based motility","volume":"10","author":"Svitkina","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2026012020432089200_R21","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.1210\/en.2006-0779","article-title":"Estrogen regulates epithelial cell deformability by modulation of cortical actomyosin through phosphorylation of nonmuscle myosin heavy-chain II-B filaments","volume":"147","author":"Li","year":"2006","journal-title":"Endocrinology"},{"key":"2026012020432089200_R22","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0002-9378(16)33500-1","article-title":"Dating the endometrial biopsy","volume":"122","author":"Noyes","year":"1975","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2026012020432089200_R23","first-page":"4010","article-title":"Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification","volume":"142","author":"Zdravkovic","year":"2015","journal-title":"Development"},{"key":"2026012020432089200_R24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10815-019-01629-0","article-title":"A novel \u2018embryo-endometrial\u2019 adhesion model can potentially predict \u2018receptive\u2019 or \u2018non-receptive\u2019 endometrium","volume":"37","author":"Evans","year":"2020","journal-title":"J. Assist. Reprod. Genet."},{"key":"2026012020432089200_R25","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2026012020432089200_R26","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkae1011","article-title":"The PRIDE database at 20 years: 2025 update","volume":"53","author":"Perez-Riverol","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"2026012020432089200_R27","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/molehr\/8.11.1014","article-title":"Adhesiveness of human uterine epithelial RL95-2 cells to trophoblast: rho protein regulation","volume":"8","author":"Heneweer","year":"2002","journal-title":"Mol. Hum. Reprod."},{"key":"2026012020432089200_R28","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1091\/mbc.e06-11-1056","article-title":"Myosin-IIA heavy-chain phosphorylation regulates the motility of MDA-MB-231 carcinoma cells","volume":"18","author":"Dulyaninova","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"2026012020432089200_R29","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1091\/mbc.e05-04-0330","article-title":"Myosin 2 is a key Rho kinase target necessary for the local concentration of E-cadherin at cell\u2013cell contacts","volume":"16","author":"Shewan","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"2026012020432089200_R30","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/ncb2072","article-title":"Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens","volume":"12","author":"Smutny","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"2026012020432089200_R31","doi-asserted-by":"crossref","first-page":"11142","DOI":"10.1111\/jcmm.17036","article-title":"Down-regulation of MYH10 driven by chromosome 17p13.1 deletion promotes hepatocellular carcinoma metastasis through activation of the EGFR pathway","volume":"25","author":"Jin","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"2026012020432089200_R32","article-title":"Endometrial stem\/progenitor cells-their role in endometrial repair and regeneration","volume":"3","author":"Cousins","year":"2021","journal-title":"Front. Reprod. Health"},{"key":"2026012020432089200_R33","article-title":"MYH10 combines with MYH9 to recruit USP45 by deubiquitinating snail and promotes serous ovarian cancer carcinogenesis, progression, and cisplatin resistance","volume":"10","author":"Liu","year":"2023","journal-title":"Adv. Sci."},{"key":"2026012020432089200_R34","doi-asserted-by":"crossref","first-page":"9110","DOI":"10.12659\/MSM.911523","article-title":"Myosin heavy chain 10 (MYH10) gene silencing reduces cell migration and invasion in the glioma cell lines U251, T98G, and SHG44 by inhibiting the Wnt\/\u03b2-catenin pathway","volume":"24","author":"Wang","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"2026012020432089200_R35","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1210\/en.2016-1877","article-title":"The endometrial polarity paradox: differential regulation of polarity within secretory-phase human endometrium","volume":"159","author":"Whitby","year":"2018","journal-title":"Endocrinology"},{"key":"2026012020432089200_R36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0079-6107(02)00037-8","article-title":"Tight junction proteins","volume":"81","author":"Gonz\u00e1lez-Mariscal","year":"2003","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"2026012020432089200_R37","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1078\/0171-9335-00270","article-title":"Tight junctions and compositionally related junctional structures in mammalian stratified epithelia and cell cultures derived therefrom","volume":"81","author":"Langbein","year":"2002","journal-title":"Eur. J. Cell Biol."},{"key":"2026012020432089200_R38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0014-5793(01)02936-2","article-title":"Cingulin interacts with F-actin in vitro","volume":"507","author":"D\u2019Atri","year":"2001","journal-title":"FEBS Lett."},{"key":"2026012020432089200_R39","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1242\/jcs.023648","article-title":"The Crumbs complex: from epithelial-cell polarity to retinal degeneration","volume":"122","author":"Bulgakova","year":"2009","journal-title":"J. Cell Sci."},{"key":"2026012020432089200_R40","doi-asserted-by":"crossref","first-page":"C634","DOI":"10.1152\/ajpcell.00559.2023","article-title":"Glucose influences endometrial receptivity to embryo implantation through O-GlcNAcylation-mediated regulation of the cytoskeleton","volume":"327","author":"Ruane","year":"2024","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2026012020432089200_R41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007787","article-title":"FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation","volume":"14","author":"Vasquez","year":"2018","journal-title":"PLoS Genet."},{"key":"2026012020432089200_R42","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2021.101656","article-title":"Main actors behind the endometrial receptivity and successful implantation","volume":"73","author":"Governini","year":"2021","journal-title":"Tissue Cell"},{"key":"2026012020432089200_R43","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1210\/endo.143.6.8885","article-title":"Global gene profiling in human endometrium during the window of implantation","volume":"143","author":"Kao","year":"2002","journal-title":"Endocrinology"},{"key":"2026012020432089200_R44","first-page":"570","article-title":"FoxO1 is a cell-specific core transcription factor for endometrial remodeling and homeostasis during menstrual cycle and early pregnancy","volume":"27","author":"Adiguzel","year":"2021","journal-title":"Hum. Reprod. Update"},{"key":"2026012020432089200_R45","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1095\/biolreprod.116.144410","article-title":"Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment","volume":"96","author":"Wetendorf","year":"2017","journal-title":"Biol. Reprod."},{"key":"2026012020432089200_R46","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1167\/iovs.04-0721","article-title":"Pdlim2, a novel PDZ-LIM domain protein, interacts with alpha-actinins and filamin A","volume":"45","author":"Torrado","year":"2004","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"2026012020432089200_R47","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1042\/BST0391131","article-title":"Distinct and redundant roles of the non-muscle myosin II isoforms and functional domains","volume":"39","author":"Wang","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"2026012020432089200_R48","doi-asserted-by":"crossref","first-page":"14645","DOI":"10.1073\/pnas.1004023107","article-title":"Nonmuscle myosin II isoform and domain specificity during early mouse development","volume":"107","author":"Wang","year":"2010","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2026012020432089200_R49","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.138530","article-title":"Conditional Myh9 and Myh10 inactivation in adult mouse renal epithelium results in progressive kidney disease","volume":"5","author":"Otterpohl","year":"2020","journal-title":"JCI Insight"},{"key":"2026012020432089200_R50","article-title":"PDLIM2: signaling pathways and functions in cancer suppression and host immunity","volume":"1876","author":"Guo","year":"2021","journal-title":"BBA Rev. Cancer"},{"key":"2026012020432089200_R51","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2922832","article-title":"High expression of PDLIM2 predicts a poor prognosis in prostate cancer and is correlated with epithelial-mesenchymal transition and immune cell infiltration","volume":"2022","author":"Piao","year":"2022","journal-title":"J. Immunol. Res."},{"key":"2026012020432089200_R52","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2017.00145","article-title":"Epithelial-to-mesenchymal transition in the female reproductive tract: from normal functioning to disease pathology","volume":"7","author":"Bilyk","year":"2017","journal-title":"Front. Oncol."},{"key":"2026012020432089200_R53","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41416-020-01178-9","article-title":"EMTome: a resource for pan-cancer analysis of epithelial\u2013mesenchymal transition genes and signatures","volume":"124","author":"Vasaikar","year":"2021","journal-title":"Br. J. Cancer"},{"key":"2026012020432089200_R54","article-title":"Supplementary material from: Myosin Heavy Chain 10 dysregulation in infertile endometrial epithelial cells impairs adhesive capacity. Figshare.","author":"Sacco","year":"2025"}],"container-title":["Open Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/rsob\/article-pdf\/doi\/10.1098\/rsob.250105\/5652191\/rsob.250105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rsob\/article-pdf\/doi\/10.1098\/rsob.250105\/5652191\/rsob.250105.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T01:43:33Z","timestamp":1768959813000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rsob\/article\/16\/1\/250105\/479553\/Myosin-heavy-chain-10-dysregulation-in-infertile"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,21]]}},"URL":"https:\/\/doi.org\/10.1098\/rsob.250105","relation":{"has-review":[{"id-type":"doi","id":"10.1098\/RSOB.250105\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.250105\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.250105\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.250105\/v2\/response1","asserted-by":"object"}]},"ISSN":["2046-2441"],"issn-type":[{"value":"2046-2441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]},"article-number":"250105"}}