{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:49:50Z","timestamp":1792136990951,"version":"4.4.0"},"reference-count":82,"publisher":"The Royal Society","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The National Institutes of Health"},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The ADAMTS (a disintegrin and metalloproteinase with thrombospondin type-1 motifs) metalloprotease family comprises 19 members, and they play critical roles in development, angiogenesis and coagulation. These enzymes are also pivotal in the turnover of extracellular matrix proteins in various tissues, and their dysregulation has been linked to diseases such as arthritis, atherosclerosis, cancer and inflammation. These secreted zinc metalloproteases are composed of multiple domains and are localized to the extracellular matrix and present in circulation. The metalloprotease member 7 of this family or ADAMTS7 was cloned in 2004. However, in 2011, it gained significant attention when its gene locus was associated with an increased risk of atherosclerosis and coronary artery disease. Despite its strong association with human diseases, the biological functions, substrate targets and processing of ADAMTS7 remain poorly understood, limiting our comprehension of its roles in both health and disease. This review highlights the structural organization of ADAMTS7, its expression and regulation, known substrates, and its involvement in various pathophysiological processes. Additionally, perspectives on future research directions and priorities are presented. ADAMTS7 remains a compelling target for drug and biomarker discovery, though much about this metalloprotease remains to be uncovered.<\/jats:p>","DOI":"10.1098\/rsob.250111","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:08:27Z","timestamp":1775002107000},"source":"Crossref","is-referenced-by-count":0,"title":["The biology and pathophysiology of the proatherogenic metalloprotease ADAMTS7"],"prefix":"10.1098","volume":"16","author":[{"given":"Shiwali","family":"Goyal","sequence":"first","affiliation":[{"name":"National Institute of Health, National Eye Institute 1 , Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Muniu","sequence":"additional","affiliation":[{"name":"Oklahoma State University College of Osteopathic Medicine 2 , Tulsa, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Akbar","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Georgetown University Medical Center 3 , Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Oldham","sequence":"additional","affiliation":[{"name":"Oklahoma State University College of Osteopathic Medicine 2 , Tulsa, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3053-7183","authenticated-orcid":false,"given":"Derrick W.","family":"Pruitt","sequence":"additional","affiliation":[{"name":"Oklahoma State University College of Osteopathic Medicine 2 , Tulsa, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Frias Perez","sequence":"additional","affiliation":[{"name":"Oklahoma State University College of Osteopathic Medicine 2 , Tulsa, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frida Z.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Oklahoma State University College of Osteopathic Medicine 2 , Tulsa, OK, USA"},{"name":"Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences 4 , Tulsa, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5011-2420","authenticated-orcid":false,"given":"Joshua","family":"Muia","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences 4 , Tulsa, OK, USA"},{"name":"Department of Biochemistry, Medical College of Wisconsin 5 , Milwaukee, WI, USA"},{"name":"Thrombosis and Hemostasis Program, Versiti Blood Research Institute 6 , Milwaukee, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"2026101603261108700_R1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/BJ20040424","article-title":"The ADAMTS metalloproteinases","volume":"386","author":"Porter","year":"2005","journal-title":"Biochem. 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Cell Biol."},{"key":"2026101603261108700_R6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13059-015-0676-3","article-title":"The ADAMTS (A disintegrin and metalloproteinase with thrombospondin motifs) family","volume":"16","author":"Kelwick","year":"2015","journal-title":"Genome Biol."},{"key":"2026101603261108700_R7","doi-asserted-by":"crossref","first-page":"31493","DOI":"10.1074\/jbc.R109.052340","article-title":"A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms","volume":"284","author":"Apte","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2026101603261108700_R8","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/ng.199","article-title":"ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation","volume":"40","author":"Le Goff","year":"2008","journal-title":"Nat. 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Sci."},{"key":"2026101603261108700_R79","first-page":"532","article-title":"Upregulation of miR\u2011423 improves autologous vein graft restenosis via targeting ADAMTS\u20117","volume":"45","author":"Ren","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"2026101603261108700_R80","first-page":"285","article-title":"miR-654-5p suppresses migration and proliferation of vascular smooth muscle cells by targeting ADAMTS-7","volume":"212","author":"Li","year":"2023","journal-title":"Cells. Tissues. 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