{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:39:33Z","timestamp":1792543173391,"version":"4.5.0"},"reference-count":400,"publisher":"The Royal Society","issue":"10","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD111322"],"award-info":[{"award-number":["R01HD111322"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Blavatnik Family Graduate Fellowship in Biology and Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Human fertility is regulated by a complex, integrated network of biological systems that collectively determine reproductive competence in males and females. Conventional fertility assessment relies on established clinical biomarkers, including reproductive hormone profiles, gamete-based functional assessments and imaging indicators of gonadal structure and function. While clinically informative, these measures capture only partial views of molecular and cellular processes underlying gametogenesis and reproductive capacity. Recent advances in reproductive medicine have expanded the biomarker landscape through genetic and epigenetic profiling, enabling identification of pathogenic variants, chromosomal abnormalities and regulatory modifications associated with infertility syndromes. In parallel, multi-omics approaches are increasingly being used to characterize molecular networks governing gamete development, meiotic integrity, DNA repair and cellular differentiation. This review presents a comprehensive synthesis of fertility biomarkers, spanning endocrine, genetic, epigenetic, structural, metabolic and inflammatory systems. Current evidence is examined on endocrine and reproductive hormone biomarkers, followed by an investigation of genetic and epigenetic markers of reproductive dysfunction, as well as structural and imaging-based biomarkers and inflammatory and metabolic indicators. Finally, emerging biomarker platforms are highlighted as key advances towards precision reproductive medicine. Collectively, these developments support a shift towards a more comprehensive, biomarker-driven framework for the evaluation and management of infertility.<\/jats:p>","DOI":"10.1098\/rsob.260199","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:14:10Z","timestamp":1792541650000},"source":"Crossref","is-referenced-by-count":0,"title":["Cracking the fertility code: a comprehensive review of biomarkers and functional measures"],"prefix":"10.1098","volume":"16","author":[{"given":"Morgan F.","family":"Woodman-Sousa","sequence":"first","affiliation":[{"name":"Molecular Biology, Cell Biology, and Biochemistry Graduate Program, Brown University 1 , Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7102-817X","authenticated-orcid":false,"given":"Kathryn","family":"Grive","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Women & Infants Hospital of Rhode Island 2 , Providence, RI, USA"},{"name":"Obstetrics and Gynecology, Brown University Warren Alpert Medical School 3 , Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"2026102020140826100_RSOB260199C1","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1097\/GRH.0000000000000052","article-title":"WHO fact sheet on infertility","volume":"6","author":"World Health Organization","year":"2021","journal-title":"Glob. Reprod. Health"},{"key":"2026102020140826100_RSOB260199C2","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.3390\/ijms25031510","article-title":"In vitro growth of human follicles: current and future perspectives","volume":"25","author":"Malo","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1095\/biolreprod50.2.225","article-title":"Ovarian follicular growth and development in mammals","volume":"50","author":"Fortune","year":"1994","journal-title":"Biol. Reprod."},{"key":"2026102020140826100_RSOB260199C4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/aja.1001940303","article-title":"The changing architecture of the neonatal rat ovary during histogenesis","volume":"194","author":"Rajah","year":"1992","journal-title":"Dev. Dyn."},{"key":"2026102020140826100_RSOB260199C5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0074-7696(08)61524-7","article-title":"Development of follicles in the mammalian ovary","volume":"124","author":"Hirshfield","year":"1991","journal-title":"Int. Rev. Cytol."},{"key":"2026102020140826100_RSOB260199C6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/19396368.2026.2631558","article-title":"Molecular mechanisms of folliculogenesis and oogenesis","volume":"72","author":"Ezz","year":"2026","journal-title":"Syst. Biol. Reprod. Med."},{"key":"2026102020140826100_RSOB260199C7","doi-asserted-by":"crossref","first-page":"103614","DOI":"10.1016\/j.semcdb.2025.103614","article-title":"The role of granulosa cells in oocyte development and aging: mechanisms and therapeutic opportunities","volume":"171","author":"Wang","year":"2025","journal-title":"Semin. Cell Dev. Biol."},{"key":"2026102020140826100_RSOB260199C8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13036-018-0134-3","article-title":"Follicle development as an orchestrated signaling network in a 3D organoid","volume":"13","author":"Jones","year":"2019","journal-title":"J. Biol. Eng."},{"key":"2026102020140826100_RSOB260199C9","volume-title":"Testing and interpreting measures of ovarian reserve: a committee opinion (2020)\u2014practice guidance","author":"ASRM"},{"key":"2026102020140826100_RSOB260199C10","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/humrep\/dem408","article-title":"A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause","volume":"23","author":"Hansen","year":"2008","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/978-3-319-44441-3_13","volume-title":"Endocrinology of the testis and male reproduction","author":"M\u00e4kel\u00e4","year":"2017"},{"key":"2026102020140826100_RSOB260199C12","volume-title":"Testes","author":"SEER Training"},{"key":"2026102020140826100_RSOB260199C13","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.3390\/ijms21155377","article-title":"The role of the epididymis and the contribution of epididymosomes to mammalian reproduction","volume":"21","author":"James","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1023\/A:1022625106489","article-title":"Physiopathological aspects of corpus luteum defect in infertile patients with mild\/minimal endometriosis","volume":"20","author":"Cunha-Filho","year":"2003","journal-title":"J. Assist. Reprod. Genet."},{"key":"2026102020140826100_RSOB260199C15","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1385\/ENDO:26:3:297","article-title":"Ovarian aging and the perimenopausal transition: the paradox of endogenous ovarian hyperstimulation","volume":"26","author":"Prior","year":"2005","journal-title":"Endocrine"},{"key":"2026102020140826100_RSOB260199C16","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0020-7292(85)90067-0","article-title":"Congenital adrenal hyperplasia and luteal dysfunction","volume":"23","author":"Villanueva","year":"1985","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"2026102020140826100_RSOB260199C17","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0022-5347(01)64503-8","article-title":"Comparison of puncture versus vasotomy techniques for vasography in an animal model","volume":"158","author":"Poore","year":"1997","journal-title":"J. Urol."},{"key":"2026102020140826100_RSOB260199C18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0015-0282(16)47291-2","article-title":"Endometrial biopsy during treatment of luteal phase defects is predictive of therapeutic outcome","volume":"40","author":"Daly","year":"1983","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C19","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0015-0282(16)46873-1","article-title":"Shortened luteal phase after ovulation induction with human menopausal gonadotropin and human chorionic gonadotropin","volume":"39","author":"Olson","year":"1983","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0165-0378(01)00134-6","article-title":"Impact of ovarian stimulation on corpus luteum function and embryonic implantation","volume":"55","author":"Tavaniotou","year":"2002","journal-title":"J. Reprod. Immunol."},{"key":"2026102020140826100_RSOB260199C21","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1210\/endo.136.12.7588276","article-title":"Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice","volume":"136","author":"Singh","year":"1995","journal-title":"Endocrinology"},{"key":"2026102020140826100_RSOB260199C22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ogc.2014.10.003","article-title":"Progesterone and the luteal phase: a requisite to reproduction","volume":"42","author":"Mesen","year":"2015","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"2026102020140826100_RSOB260199C23","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0015-0282(98)00531-7","article-title":"Reference values for the midluteal plasma progesterone concentration: evidence from human menopausal gonadotropin-stimulated pregnancy cycles","volume":"71","author":"Sallam","year":"1999","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/humupd\/dmi033","article-title":"Transcriptional regulation of early oogenesis: in search of masters","volume":"12","author":"Pangas","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"2026102020140826100_RSOB260199C25","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1242\/dev.127.21.4645","article-title":"FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation","volume":"127","author":"Soyal","year":"2000","journal-title":"Development"},{"key":"2026102020140826100_RSOB260199C26","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.ajhg.2008.04.018","article-title":"Transcription factor FIGLA is mutated in patients with premature ovarian failure","volume":"82","author":"Zhao","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"2026102020140826100_RSOB260199C27","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.1099755","article-title":"NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression","volume":"305","author":"Rajkovic","year":"2004","journal-title":"Science"},{"key":"2026102020140826100_RSOB260199C28","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1086\/519496","article-title":"NOBOX homeobox mutation causes premature ovarian failure","volume":"81","author":"Qin","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"2026102020140826100_RSOB260199C29","doi-asserted-by":"crossref","first-page":"8090","DOI":"10.1073\/pnas.0601083103","article-title":"Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8","volume":"103","author":"Pangas","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026102020140826100_RSOB260199C30","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1095\/biolreprod.108.071217","article-title":"Germ cell-specific transcriptional regulator sohlh2 is essential for early mouse folliculogenesis and oocyte-specific gene expression","volume":"79","author":"Choi","year":"2008","journal-title":"Biol. Reprod."},{"key":"2026102020140826100_RSOB260199C31","doi-asserted-by":"crossref","first-page":"e1006128","DOI":"10.1371\/journal.pgen.1006128","article-title":"TAF4b Regulates oocyte-specific genes essential for meiosis","volume":"12","author":"Grive","year":"2016","journal-title":"PLoS Genet."},{"key":"2026102020140826100_RSOB260199C32","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/deae108.906","article-title":"P-571 mutations in FOXO3 mutation cause human premature ovarian insufficiency","volume":"39","author":"Sun","year":"2024","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C33","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1093\/biolre\/ioaf013","article-title":"Unveiling the role of FOXL2 in female differentiation and disease: a comprehensive review\u2020","volume":"112","author":"He","year":"2025","journal-title":"Biol. Reprod."},{"key":"2026102020140826100_RSOB260199C34","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1093\/hmg\/ddx075","article-title":"The Wilms tumor protein Wt1 contributes to female fertility by regulating oviductal proteostasis","volume":"26","author":"Nathan","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"2026102020140826100_RSOB260199C35","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/biolre\/ioz084","article-title":"Genetics of human female infertility","volume":"101","author":"Yatsenko","year":"2019","journal-title":"Biol. Reprod."},{"key":"2026102020140826100_RSOB260199C36","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1093\/hmg\/ddw186","article-title":"A recurrent p.Arg92Trp variant in steroidogenic factor-1 (NR5A1) can act as a molecular switch in human sex development","volume":"25","author":"Bashamboo","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"2026102020140826100_RSOB260199C37","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1210\/endocr\/bqab093","article-title":"WNT4 balances development vs disease in gynecologic tissues and women's health","volume":"162","author":"Pitzer","year":"2021","journal-title":"Endocrinology"},{"key":"2026102020140826100_RSOB260199C38","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.rbmo.2015.01.012","article-title":"Down-regulation of the CYP19A1 gene in cumulus cells of infertile women with endometriosis","volume":"30","author":"Barcelos","year":"2015","journal-title":"Reprod. Biomed. Online"},{"key":"2026102020140826100_RSOB260199C39","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S1472-6483(10)60009-0","article-title":"Aromatase gene (CYP19A1) variants, female infertility and ovarian stimulation outcome: a preliminary report","volume":"18","author":"Altm\u00e4e","year":"2009","journal-title":"Reprod. Biomed. Online"},{"key":"2026102020140826100_RSOB260199C40","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0092-8674(95)90275-9","article-title":"Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure","volume":"82","author":"Aittom\u00e4ki","year":"1995","journal-title":"Cell"},{"key":"2026102020140826100_RSOB260199C41","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1242\/dev.113.2.613","article-title":"Expression of the mouse anti-M\u00fcllerian hormone gene suggests a role in both male and female sexual differentiation","volume":"113","author":"M\u00fcnsterberg","year":"1991","journal-title":"Development"},{"key":"2026102020140826100_RSOB260199C42","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/humrep\/dem036","article-title":"Anti-M\u00fcllerian hormone and anti-M\u00fcllerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women","volume":"22","author":"Kevenaar","year":"2007","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C43","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s10815-015-0562-7","article-title":"Use of anti-mullerian hormone for testing ovarian reserve: a survey of 796 infertility clinics worldwide","volume":"32","author":"Tobler","year":"2015","journal-title":"J. Assist. Reprod. Genet."},{"key":"2026102020140826100_RSOB260199C44","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/humupd\/dmu020","article-title":"Anti-M\u00fcllerian hormone: ovarian reserve testing and its potential clinical implications","volume":"20","author":"Broer","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"2026102020140826100_RSOB260199C45","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/S0140-6736(26)00717-8","article-title":"Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process","volume":"407","author":"Teede","year":"2026","journal-title":"Lancet"},{"key":"2026102020140826100_RSOB260199C46","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1095\/biolreprod50.3.653","article-title":"Age-related changes of the population of human ovarian follicles: increase in the disappearance rate of non-growing and early-growing follicles in aging women","volume":"50","author":"Gougeon","year":"1994","journal-title":"Biol. Reprod."},{"key":"2026102020140826100_RSOB260199C47","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.fertnstert.2011.10.031","article-title":"A characterization of the relationship of ovarian reserve markers with age","volume":"97","author":"Rosen","year":"2012","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C48","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.reprotox.2008.07.005","article-title":"Correlation of serum anti-M\u00fcllerian hormone with accelerated follicle loss following 4-vinylcyclohexene diepoxide-induced follicle loss in mice","volume":"26","author":"Sahambi","year":"2008","journal-title":"Reprod. Toxicol."},{"key":"2026102020140826100_RSOB260199C49","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1016\/j.fertnstert.2009.12.045","article-title":"Antral follicle count: absence of significant midlife decline","volume":"94","author":"Rosen","year":"2010","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C50","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1016\/j.fertnstert.2007.10.028","article-title":"Establishing the intercycle variability of three-dimensional ultrasonographic predictors of ovarian reserve","volume":"90","author":"Jayaprakasan","year":"2008","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C51","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1093\/humrep\/dem105","article-title":"Loss of ovarian reserve after uterine artery embolization: a randomized comparison with hysterectomy","volume":"22","author":"Hehenkamp","year":"2007","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C52","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/humrep\/deh688","article-title":"High reproducibility of serum anti-Mullerian hormone measurements suggests a multi-staged follicular secretion and strengthens its role in the assessment of ovarian follicular status","volume":"20","author":"Fanchin","year":"2005","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C53","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1093\/humrep\/dem101","article-title":"Stable serum levels of anti-M\u00fcllerian hormone during the menstrual cycle: a prospective study in normo-ovulatory women","volume":"22","author":"Tsepelidis","year":"2007","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C54","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1093\/humrep\/del291","article-title":"Serum anti-Mullerian hormone throughout the human menstrual cycle","volume":"21","author":"La Marca","year":"2006","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C55","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1210\/jc.2006-0331","article-title":"Anti-M\u00fcllerian hormone levels in the spontaneous menstrual cycle do not show substantial fluctuation","volume":"91","author":"Hehenkamp","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C56","volume-title":"Testing and interpreting measures of ovarian reserve: a committee opinion (2020) - practice guidance","author":"American Society for Reproductive Medicine"},{"key":"2026102020140826100_RSOB260199C57","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s13643-024-02684-0","article-title":"The best ovarian reserve marker to predict ovarian response following controlled ovarian hyperstimulation: a systematic review and meta-analysis","volume":"13","author":"Salemi","year":"2024","journal-title":"Syst. Rev."},{"key":"2026102020140826100_RSOB260199C58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/5246217","article-title":"Anti-mullerian hormone: above and beyond conventional ovarian reserve markers","volume":"2016","author":"Jamil","year":"2016","journal-title":"Dis. Markers"},{"key":"2026102020140826100_RSOB260199C59","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1210\/jc.2012-4228","article-title":"The relationship between anti-M\u00fcllerian hormone in women receiving fertility assessments and age at menopause in subfertile women: evidence from large population studies","volume":"98","author":"D\u00f3lleman","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C60","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.fertnstert.2012.07.1139","article-title":"Contribution of the rate of change of antim\u00fcllerian hormone in estimating time to menopause for late reproductive-age women","volume":"98","author":"Freeman","year":"2012","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C61","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1001\/jama.2017.14588","article-title":"Association between biomarkers of ovarian reserve and infertility among older women of reproductive age","volume":"318","author":"Steiner","year":"2017","journal-title":"JAMA"},{"key":"2026102020140826100_RSOB260199C62","doi-asserted-by":"crossref","first-page":"e240630","DOI":"10.1530\/EC-24-0630","article-title":"From biological marker to clinical application: the role of anti-M\u00fcllerian hormone for delayed puberty and idiopathic non-obstructive azoospermia in males","volume":"14","author":"Zeng","year":"2025","journal-title":"Endocr. Connect."},{"key":"2026102020140826100_RSOB260199C63","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-0044-1787687","article-title":"Role of anti-M\u00fcllerian hormone in male reproduction and sperm motility","volume":"42","author":"Benderradji","year":"2024","journal-title":"Semin. Reprod. Med."},{"key":"2026102020140826100_RSOB260199C64","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/aja.aja_83_18","article-title":"Regulation of anti-M\u00fcllerian hormone (AMH) in males and the associations of serum AMH with the disorders of male fertility","volume":"21","author":"Xu","year":"2019","journal-title":"Asian J. Androl."},{"key":"2026102020140826100_RSOB260199C65","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/GRF.0000000000000445","article-title":"Ovarian reserve testing: areview of the options, their applications, and their limitations","volume":"62","author":"Ulrich","year":"2019","journal-title":"Clin. Obstet. Gynecol."},{"key":"2026102020140826100_RSOB260199C66","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mce.2017.10.015","article-title":"Gonadotropin regulation by pulsatile GnRH: signaling and gene expression","volume":"463","author":"Stamatiades","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"2026102020140826100_RSOB260199C67","doi-asserted-by":"crossref","first-page":"102477","DOI":"10.1016\/j.jbc.2022.102477","article-title":"Estradiol production of granulosa cells is unaffected by the physiological mix of nonesterified fatty acids in follicular fluid","volume":"298","author":"Baddela","year":"2022","journal-title":"J. Biol. Chem."},{"key":"2026102020140826100_RSOB260199C68","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ajog.2017.02.027","article-title":"Ovarian reserve testing: a user's guide","volume":"217","author":"Tal","year":"2017","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2026102020140826100_RSOB260199C69","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1093\/humrep\/der391","article-title":"Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women","volume":"27","author":"Schuh-Huerta","year":"2012","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C70","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-4939-0659-8_7","article-title":"The endocrinology of the menstrual cycle","author":"Barbieri","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"2026102020140826100_RSOB260199C71","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1210\/jc.2009-2108","article-title":"Estrogen negative feedback on gonadotropin secretion: evidence for a direct pituitary effect in women","volume":"95","author":"Shaw","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C72","volume-title":"What FSH levels can tell you about your fertility","author":"Pacific Centre for Reproductive Medicine"},{"key":"2026102020140826100_RSOB260199C73","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/humrep\/deh119","article-title":"Intercycle variability of ovarian reserve tests: results of a prospective randomized study","volume":"19","author":"Kwee","year":"2004","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C74","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0015-0282(16)53707-8","article-title":"Intercycle variability of day 3 follicle-stimulating hormone levels and its effect on stimulation quality in in vitro fertilization","volume":"54","author":"Scott","year":"1990","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C75","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/humrep\/dem254","article-title":"Serum anti-M\u00fcllerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles","volume":"23","author":"Lee","year":"2008","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C76","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3389\/fendo.2019.00322","article-title":"Clinical use of FSH in male infertility","volume":"10","author":"Behre","year":"2019","journal-title":"Front. Endocrinol.)"},{"key":"2026102020140826100_RSOB260199C77","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.fertnstert.2008.07.1703","article-title":"High serum FSH levels in men with nonobstructive azoospermia does not affect success of microdissection testicular sperm extraction","volume":"92","author":"Ramasamy","year":"2009","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C78","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.3390\/jcm9041014","article-title":"Follicle-stimulating hormone (FSH) action on spermatogenesis: a focus on physiological and therapeutic roles","volume":"9","author":"Santi","year":"2020","journal-title":"J. Clin. Med."},{"key":"2026102020140826100_RSOB260199C79","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12958-022-00971-w","article-title":"Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis","volume":"20","author":"Wang","year":"2022","journal-title":"Reprod. Biol. Endocrinol."},{"key":"2026102020140826100_RSOB260199C80","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1007\/s10815-021-02313-y","article-title":"FSH levels and testicular volumes are associated with the severity of testicular histopathology in men with non-obstructive azoospermia","volume":"38","author":"Kavoussi","year":"2021","journal-title":"J. Assist. Reprod. Genet."},{"key":"2026102020140826100_RSOB260199C81","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/life12010010","article-title":"Endocrinopathies and male infertility","volume":"12","author":"Sengupta","year":"2021","journal-title":"Life"},{"key":"2026102020140826100_RSOB260199C82","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1464-410X.2011.10783.x","article-title":"Redefining abnormal follicle-stimulating hormone in the male infertility population","volume":"110","author":"Gordetsky","year":"2012","journal-title":"BJU Int."},{"key":"2026102020140826100_RSOB260199C83","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12958-015-0028-x","article-title":"Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring","volume":"13","author":"Sharma","year":"2015","journal-title":"Reprod. Biol. Endocrinol."},{"key":"2026102020140826100_RSOB260199C84","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s10020-023-00771-x","article-title":"Diabetes-induced male infertility: potential mechanisms and treatment options","volume":"30","author":"Huang","year":"2024","journal-title":"Mol. Med."},{"key":"2026102020140826100_RSOB260199C85","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1210\/jcem-61-3-525","article-title":"Follicle-stimulating hormone-secreting pituitary adenomas","volume":"61","author":"Beckers","year":"1985","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C86","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4103\/1008-682X.173932","article-title":"The role of estradiol in male reproductive function","volume":"18","author":"Schulster","year":"2016","journal-title":"Asian J. Androl."},{"key":"2026102020140826100_RSOB260199C87","doi-asserted-by":"crossref","first-page":"39931","DOI":"10.1038\/srep39931","article-title":"Effects of elevated \u03b2-estradiol levels on the functional morphology of the testis - new insights","volume":"7","author":"Leavy","year":"2017","journal-title":"Sci. Rep."},{"key":"2026102020140826100_RSOB260199C88","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1210\/endo-64-4-600","article-title":"Conversion of C14-testosterone to C14-estrogenic steroids by endocrine tissues","volume":"64","author":"Baggett","year":"1959","journal-title":"Endocrinology"},{"key":"2026102020140826100_RSOB260199C89","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1677\/jme.0.0320279","article-title":"Human immature germ cells and ejaculated spermatozoa contain aromatase and oestrogen receptors","volume":"32","author":"Lambard","year":"2004","journal-title":"J. Mol. Endocrinol."},{"key":"2026102020140826100_RSOB260199C90","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/molehr\/gag020","article-title":"Expression of aromatase in human ejaculated spermatozoa: a putative marker of motility","volume":"9","author":"Lambard","year":"2003","journal-title":"Mol. Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C91","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.0021-8782.2004.00272.x","article-title":"Aromatase immunolocalization in human ductuli efferentes and proximal ductus epididymis","volume":"204","author":"Carpino","year":"2004","journal-title":"J. Anat."},{"key":"2026102020140826100_RSOB260199C92","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1677\/joe.0.1720021","article-title":"Development and validation of a new monoclonal antibody to mammalian aromatase","volume":"172","author":"Turner","year":"2002","journal-title":"J. Endocrinol."},{"key":"2026102020140826100_RSOB260199C93","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1093\/oxfordjournals.humrep.a138394","article-title":"Germ cell and Sertoli cell interactions in human testis: evidence for stimulatory and inhibitory effects","volume":"9","author":"Foucault","year":"1994","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C94","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/37352","article-title":"A role for oestrogens in the male reproductive system","volume":"390","author":"Hess","year":"1997","journal-title":"Nature"},{"key":"2026102020140826100_RSOB260199C95","first-page":"203","article-title":"The direct effect of 17 beta-estradiol on LH-stimulated testosterone production in hypophysectomized rats","volume":"13","author":"Melner","year":"1980","journal-title":"J. Steroid Biochem.Mol. Biol."},{"key":"2026102020140826100_RSOB260199C96","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.3390\/ijms15057812","article-title":"Effects of estradiol and methoxychlor on Leydig cell regeneration in the adult rat testis","volume":"15","author":"Chen","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C97","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jsbmb.2012.11.019","article-title":"Regulation of apoptotic signaling pathways by 5\u03b1-dihydrotestosterone and 17\u03b2-estradiol in immature rat Sertoli cells","volume":"135","author":"Sim\u00f5es","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"2026102020140826100_RSOB260199C98","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/boc.201500094","article-title":"Estradiol modulates Na(+)-dependent HCO3(-) transporters altering intracellular pH and ion transport in human Sertoli cells: a role on male fertility?","volume":"108","author":"Bernardino","year":"2016","journal-title":"Biol. Cell"},{"key":"2026102020140826100_RSOB260199C99","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1172\/JCI109716","article-title":"Estrogen dependence of a gonadotropin-induced steroidogenic lesion in rat testicular Leydig cells","volume":"65","author":"Cicorraga","year":"1980","journal-title":"J. Clin. Invest."},{"key":"2026102020140826100_RSOB260199C100","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/1933719116649696","article-title":"PI3K\/Akt activated by GPR30 and Src regulates 17\u03b2-estradiol-induced cultured immature boar Sertoli cells proliferation","volume":"24","author":"Yang","year":"2017","journal-title":"Reprod. Sci."},{"key":"2026102020140826100_RSOB260199C101","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/j.1939-4640.1991.tb01604.x","article-title":"17 beta-estradiol inhibition of Leydig cell regeneration in the ethane dimethylsulfonate-treated mature rat","volume":"12","author":"Abney","year":"1991","journal-title":"J. Androl."},{"key":"2026102020140826100_RSOB260199C102","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0039-128X(78)90021-1","article-title":"Further characterization of the effects of hypophysectomy, FSH and estrogen on LH stimulation of testosterone production in Leydig cells isolated from immature rats","volume":"31","author":"van Beurden","year":"1978","journal-title":"Steroids"},{"key":"2026102020140826100_RSOB260199C103","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1095\/biolreprod55.4.782","article-title":"Estrogen receptor messenger ribonucleic acid changes during Leydig cell development","volume":"55","author":"Zhai","year":"1996","journal-title":"Biol. Reprod."},{"key":"2026102020140826100_RSOB260199C104","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1210\/endo.138.1.4831","article-title":"Estrogens potentiate the stimulatory effects of follicle-stimulating hormone on N-cadherin messenger ribonucleic acid levels in cultured mouse Sertoli cells","volume":"138","author":"MacCalman","year":"1997","journal-title":"Endocrinology"},{"key":"2026102020140826100_RSOB260199C105","first-page":"2057","article-title":"Estradiol acts as a germ cell survival factor in the human testis in vitro","volume":"85","author":"Pentik\u00e4inen","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C106","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1095\/biolreprod.111.096891","article-title":"17Beta-estradiol signaling and regulation of proliferation and apoptosis of rat Sertoli cells","volume":"86","author":"Royer","year":"2012","journal-title":"Biol. Reprod."},{"key":"2026102020140826100_RSOB260199C107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2014.00001","article-title":"Role of estrogen receptors and g protein-coupled estrogen receptor in regulation of hypothalamus-pituitary-testis axis and spermatogenesis","volume":"5","author":"Chimento","year":"2014","journal-title":"Front. Endocrinol."},{"key":"2026102020140826100_RSOB260199C108","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.mce.2010.01.035","article-title":"17 beta-estradiol activates rapid signaling pathways involved in rat pachytene spermatocytes apoptosis through GPR30 and ER alpha","volume":"320","author":"Chimento","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"2026102020140826100_RSOB260199C109","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/mrd.1151","article-title":"17 beta-estradiol induces spermatogonial proliferation through mitogen-activated protein kinase (extracellular signal-regulated kinase 1\/2) activity in the lizard (Podarcis s. sicula)","volume":"61","author":"Chieffi","year":"2002","journal-title":"Mol. Reprod. Dev."},{"key":"2026102020140826100_RSOB260199C110","doi-asserted-by":"crossref","first-page":"e248","DOI":"10.1016\/j.fertnstert.2023.08.700","article-title":"Distribution of testosterone to estradiol ratios in fertile and subfertile men: a large cohort analysis","volume":"120","author":"Hayon","year":"2023","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C111","doi-asserted-by":"crossref","first-page":"453","DOI":"10.5534\/wjmh.240029","article-title":"A review on testosterone: estradiol ratio-does it matter, how do you measure it, and can you optimize it?","volume":"43","author":"Swislocki","year":"2025","journal-title":"World J. Mens Health."},{"key":"2026102020140826100_RSOB260199C112","first-page":"66","article-title":"The role of estrogen modulators in male hypogonadism and infertility","volume":"18","author":"Rambhatla","year":"2016","journal-title":"Rev. Urol."},{"key":"2026102020140826100_RSOB260199C113","first-page":"e91975","article-title":"Strategies for reversing exogenous testosterone-induced infertility","volume":"17","author":"Liberto","year":"2025","journal-title":"Cureus"},{"key":"2026102020140826100_RSOB260199C114","doi-asserted-by":"crossref","first-page":"626534","DOI":"10.3389\/fendo.2021.626534","article-title":"Can inhibin B reflect ovarian reserve of healthy reproductive age women effectively?","volume":"12","author":"Wen","year":"2021","journal-title":"Front. Endocrinol."},{"key":"2026102020140826100_RSOB260199C115","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/humupd\/dmv058","article-title":"Activins in reproductive biology and beyond","volume":"22","author":"Wijayarathna","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"2026102020140826100_RSOB260199C116","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrendo.2011.224","article-title":"Anti-M\u00fcllerian hormone: an ovarian reserve marker in primary ovarian insufficiency","volume":"8","author":"Visser","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"2026102020140826100_RSOB260199C117","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/humupd\/8.6.529","article-title":"Inhibins, activins and follistatin in reproduction","volume":"8","author":"de Kretser","year":"2002","journal-title":"Hum. Reprod. Update."},{"key":"2026102020140826100_RSOB260199C118","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0301-2115(00)00319-5","article-title":"Correlation between serum inhibin B and other indicators of the ovarian function","volume":"94","author":"Tinkanen","year":"2001","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"2026102020140826100_RSOB260199C119","first-page":"2742","article-title":"Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women: a study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles","volume":"81","author":"Klein","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C120","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0015-0282(98)00127-7","article-title":"Dimeric inhibin: a direct marker of ovarian aging","volume":"70","author":"Danforth","year":"1998","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C121","first-page":"105","article-title":"Female reproductive aging is marked by decreased secretion of dimeric inhibin","volume":"84","author":"Welt","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C122","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1093\/humrep\/dem081","article-title":"The number of small antral follicles (2-6 mm) determines the outcome of endocrine ovarian reserve tests in a subfertile population","volume":"22","author":"Haadsma","year":"2007","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C123","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1631\/jzus.B0820029","article-title":"Dynamic measurements of serum inhibin B and estradiol: a predictive evaluation of ovarian response to gonadotrophin stimulation in the early stage of IVF treatment","volume":"10","author":"Miao","year":"2009","journal-title":"J. Zhejiang Univ. Sci. B."},{"key":"2026102020140826100_RSOB260199C124","first-page":"1401","article-title":"Measurement of dimeric inhibin B throughout the human menstrual cycle","volume":"81","author":"Groome","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C125","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1210\/jcem.83.9.5121","article-title":"Serum inhibin B as a marker of spermatogenesis","volume":"83","author":"Pierik","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C126","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.fertnstert.2006.01.022","article-title":"Inhibin B is a better marker of spermatogenesis than other hormones in the evaluation of male factor infertility","volume":"86","author":"Kumanov","year":"2006","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C127","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1046\/j.1365-2265.2001.01302.x","article-title":"Increased serum inhibin B levels after varicocele treatment","volume":"54","author":"Pierik","year":"2001","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"2026102020140826100_RSOB260199C128","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1530\/eje.0.1450561","article-title":"Inhibin B in male reproduction: pathophysiology and clinical relevance","volume":"145","author":"Meachem","year":"2001","journal-title":"Eur. J. Endocrinol."},{"key":"2026102020140826100_RSOB260199C129","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1093\/humrep\/12.11.2376","article-title":"Inhibin B in men with normal and disturbed spermatogenesis","volume":"12","author":"Klingmuller","year":"1997","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C130","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3390\/life12040511","article-title":"Inhibin-B and FSH are good indicators of spermatogenesis but not the best indicators of fertility","volume":"12","author":"Jankowska","year":"2022","journal-title":"Life"},{"key":"2026102020140826100_RSOB260199C131","first-page":"3341","article-title":"Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction","volume":"81","author":"Anawalt","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C132","first-page":"4451","article-title":"Different roles of prepubertal and postpubertal germ cells and Sertoli cells in the regulation of serum inhibin B levels","volume":"83","author":"Andersson","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C133","doi-asserted-by":"crossref","first-page":"e0153843","DOI":"10.1371\/journal.pone.0153843","article-title":"A normative model of serum inhibin B in young males","volume":"11","author":"Kelsey","year":"2016","journal-title":"PLoS ONE"},{"key":"2026102020140826100_RSOB260199C134","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0304-4157(88)90012-3","article-title":"Pituitary glycoprotein hormone oligosaccharides: structure, synthesis and function of the asparagine-linked oligosaccharides on lutropin, follitropin and thyrotropin","volume":"947","author":"Baenziger","year":"1988","journal-title":"Biochim. Biophys. Acta"},{"key":"2026102020140826100_RSOB260199C135","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12958-025-01353-8","article-title":"The role of LH in follicle development: from physiology to new clinical implications","volume":"23","author":"Longo","year":"2025","journal-title":"Reprod. Biol. Endocrinol."},{"key":"2026102020140826100_RSOB260199C136","doi-asserted-by":"crossref","first-page":"907249","DOI":"10.3389\/fendo.2022.907249","article-title":"Luteinizing hormone supplementation in women with hypogonadotropic hypogonadism seeking fertility care: insights from a narrative review","volume":"13","author":"Di Segni","year":"2022","journal-title":"Front. Endocrinol."},{"key":"2026102020140826100_RSOB260199C137","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/0974-1208.82351","article-title":"Luteinizing hormone and its dilemma in ovulation induction","volume":"4","author":"Kumar","year":"2011","journal-title":"J. Hum. Reprod. Sci."},{"key":"2026102020140826100_RSOB260199C138","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/humupd\/8.6.543","article-title":"The use of LH activity to drive folliculogenesis: exploring uncharted territories in ovulation induction","volume":"8","author":"Filicori","year":"2002","journal-title":"Hum. Reprod. Update"},{"key":"2026102020140826100_RSOB260199C139","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4103\/0974-1208.126285","article-title":"Luteinizing hormone and follicle stimulating hormone synergy: areview of role in controlled ovarian hyper-stimulation","volume":"6","author":"Rama Raju","year":"2013","journal-title":"J. Hum. Reprod. Sci."},{"key":"2026102020140826100_RSOB260199C140","doi-asserted-by":"crossref","first-page":"640047","DOI":"10.3389\/fendo.2021.640047","article-title":"Low serum LH levels during ovarian stimulation with GnRH antagonist protocol decrease the live birth rate after fresh embryo transfers but have no impact in freeze-all cycles","volume":"12","author":"Luo","year":"2021","journal-title":"Front. Endocrinol ."},{"key":"2026102020140826100_RSOB260199C141","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1477-7827-12-95","article-title":"A review of luteinising hormone and human chorionic gonadotropin when used in assisted reproductive technology","volume":"12","author":"Ezcurra","year":"2014","journal-title":"Reprod. Biol. Endocrinol."},{"key":"2026102020140826100_RSOB260199C142","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.3390\/ijms26083548","article-title":"Luteinizing hormone regulates testosterone production, Leydig cell proliferation, differentiation, and circadian rhythm during spermatogenesis","volume":"26","author":"Lei","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C143","doi-asserted-by":"crossref","first-page":"12735","DOI":"10.3390\/ijms222312735","article-title":"The roles of luteinizing hormone, follicle-stimulating hormone and testosterone in spermatogenesis and folliculogenesis revisited","volume":"22","author":"Oduwole","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C144","volume-title":"Endotext","author":"Hayes","year":"2000"},{"key":"2026102020140826100_RSOB260199C145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.6061\/clinics\/2013(Sup01)09","article-title":"Hypogonadotropic hypogonadism revisited","volume":"68","author":"Fraietta","year":"2013","journal-title":"Clinics"},{"key":"2026102020140826100_RSOB260199C146","doi-asserted-by":"crossref","first-page":"S367","DOI":"10.21037\/tau.2018.03.25","article-title":"Update on male reproductive endocrinology","volume":"7","author":"Clavijo","year":"2018","journal-title":"Transl. Androl. Urol."},{"key":"2026102020140826100_RSOB260199C147","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1136\/bmj.291.6509.1598","article-title":"Loss of pulsatile luteinising hormone secretion in men with chronic renal failure","volume":"291","author":"Rodger","year":"1985","journal-title":"Br.Med. J.(Clin. Res. Ed.)"},{"key":"2026102020140826100_RSOB260199C148","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1152\/physrev.2000.80.4.1523","article-title":"Prolactin: structure, function, and regulation of secretion","volume":"80","author":"Freeman","year":"2000","journal-title":"Physiol. Rev."},{"key":"2026102020140826100_RSOB260199C149","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.rbmo.2021.07.001","article-title":"The follicular fluid adipocytokine milieu could serve as a prediction tool for fertility treatment outcomes","volume":"43","author":"Wyse","year":"2021","journal-title":"Reprod. Biomed. Online"},{"key":"2026102020140826100_RSOB260199C150","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1055\/s-2007-1010803","article-title":"Endocrine parameters of human follicular fluid and fertilization capacity of oocytes","volume":"20","author":"Lindner","year":"1988","journal-title":"Horm. Metab. Res."},{"key":"2026102020140826100_RSOB260199C151","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/BF01533761","article-title":"Relationship between the steroid and prolactin concentration in follicular fluid and the maturation and fertilization of human oocytes","volume":"4","author":"Reinthaller","year":"1987","journal-title":"J. In Vitro Fert. Embryo Transf."},{"key":"2026102020140826100_RSOB260199C152","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/BF01555465","article-title":"Relationship of human oocyte maturity, fertilization, and cleavage to follicular fluid prolactin and steroids","volume":"4","author":"Lee","year":"1987","journal-title":"J. In Vitro Fert. Embryo Transf."},{"key":"2026102020140826100_RSOB260199C153","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3390\/ph16010122","article-title":"Prolactin relationship with fertility and In vitro fertilization outcomes-A review of the literature","volume":"16","author":"Iancu","year":"2023","journal-title":"Pharmaceuticals"},{"key":"2026102020140826100_RSOB260199C154","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1093\/humrep\/deg496","article-title":"Prolactin acts as a potent survival factor against C2-ceramide-induced apoptosis in human granulosa cells","volume":"18","author":"Perks","year":"2003","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C155","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/molehr\/gax035","article-title":"Improvement of implantation potential in mouse blastocysts derived from IVF by combined treatment with prolactin, epidermal growth factor and 4-hydroxyestradiol","volume":"23","author":"Takeuchi","year":"2017","journal-title":"Mol. Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C156","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2478\/v10011-011-0039-x","article-title":"Impact of transitory hyperprolactinemia on clinical outcome of in vitro fertilization and embryo transfer","volume":"31","author":"Zhong","year":"2012","journal-title":"J. Med. Biochem."},{"key":"2026102020140826100_RSOB260199C157","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1530\/jrf.0.0650559","article-title":"Evidence for direct inhibition of ovarian function by prolactin","volume":"65","author":"McNeilly","year":"1982","journal-title":"J. Reprod. Fertil."},{"key":"2026102020140826100_RSOB260199C158","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fimmu.2018.00073","article-title":"Prolactin and autoimmunity","volume":"9","author":"Borba","year":"2018","journal-title":"Front. Immunol."},{"key":"2026102020140826100_RSOB260199C159","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1210\/jcem-56-3-474","article-title":"Serum follicle-stimulating hormone, luteinizing hormone, and prolactin during the induction of ovulation with exogenous gonadotropin","volume":"56","author":"Healy","year":"1983","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C160","first-page":"291","article-title":"Involvement of corticotropin-releasing hormone and endogenous opioid peptides in prolactin-suppressed gonadotropin-releasing hormone release in vitro","volume":"60","author":"Calogero","year":"1994","journal-title":"Neuroendocrinology"},{"key":"2026102020140826100_RSOB260199C161","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/00006254-198312000-00001","article-title":"Galactorrhea and hyperprolactinemia","volume":"38","author":"Sakiyama","year":"1983","journal-title":"Obstet. Gynecol. Surv."},{"key":"2026102020140826100_RSOB260199C162","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1172\/JCI64455","article-title":"Hyperprolactinemia and infertility: new insights","volume":"122","author":"Kaiser","year":"2012","journal-title":"J. Clin. Invest."},{"key":"2026102020140826100_RSOB260199C163","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s11154-024-09902-z","article-title":"Prolactin deficiency in the context of other pituitary hormone abnormalities\u202f: special issue: hypoprolactinemia: a neglected endocrine disorder","volume":"25","author":"Shimon","year":"2024","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"2026102020140826100_RSOB260199C164","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.aju.2017.10.002","article-title":"Hyperprolactinaemia in male infertility: clinical case scenarios","volume":"16","author":"Dabbous","year":"2018","journal-title":"Arab J. Urol."},{"key":"2026102020140826100_RSOB260199C165","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000499470","article-title":"Dopamine agonists: from the 1970s to today","volume":"109","author":"Auriemma","year":"2019","journal-title":"Neuroendocrinology"},{"key":"2026102020140826100_RSOB260199C166","first-page":"149","article-title":"Clinical manifestations, evaluation and management of hyperprolactinemia in adolescent and young girls: a brief review","volume":"90","author":"Matalliotakis","year":"2019","journal-title":"Acta Biomed."},{"key":"2026102020140826100_RSOB260199C167","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4103\/0974-1208.86094","article-title":"Hyperprolactinemia: an often missed cause of male infertility","volume":"4","author":"Singh","year":"2011","journal-title":"J. Hum. Reprod. Sci."},{"key":"2026102020140826100_RSOB260199C168","doi-asserted-by":"crossref","first-page":"e433","DOI":"10.1097\/MJT.0000000000000777","article-title":"Sexual functioning in hyperprolactinemic patients treated with cabergoline or bromocriptine","volume":"26","author":"Krysiak","year":"2019","journal-title":"Am. J. Ther."},{"key":"2026102020140826100_RSOB260199C169","doi-asserted-by":"crossref","first-page":"101665","DOI":"10.1016\/j.beem.2022.101665","article-title":"Basics of androgen synthesis and action","volume":"36","author":"Naamneh Elzenaty","year":"2022","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C170","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1111\/jcmm.16205","article-title":"The role of androgen and its related signals in PCOS","volume":"25","author":"Ye","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"2026102020140826100_RSOB260199C171","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/molehr\/gat065","article-title":"Involvement of androgens in ovarian health and disease","volume":"19","author":"Lebbe","year":"2013","journal-title":"Mol. Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C172","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1016\/j.ajpath.2013.02.028","article-title":"Androgen receptor roles in the development of benign prostate hyperplasia","volume":"182","author":"Izumi","year":"2013","journal-title":"Am. J. Pathol."},{"key":"2026102020140826100_RSOB260199C173","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1016\/j.fertnstert.2011.04.083","article-title":"Androgen pretreatment in poor responders undergoing controlled ovarian stimulation and in vitro fertilization treatment","volume":"95","author":"Sunkara","year":"2011","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C174","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1477-7827-9-67","article-title":"Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR)","volume":"9","author":"Gleicher","year":"2011","journal-title":"Reprod. Biol. Endocrinol."},{"key":"2026102020140826100_RSOB260199C175","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.rbmo.2010.04.006","article-title":"Improvement in diminished ovarian reserve after dehydroepiandrosterone supplementation","volume":"21","author":"Gleicher","year":"2010","journal-title":"Reprod. Biomed. Online"},{"key":"2026102020140826100_RSOB260199C176","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1093\/humrep\/deq220","article-title":"Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study","volume":"25","author":"Wiser","year":"2010","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C177","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1093\/humrep\/del254","article-title":"Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF","volume":"21","author":"Barad","year":"2006","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C178","doi-asserted-by":"crossref","first-page":"756.e1\u2014756.e3","DOI":"10.1016\/j.fertnstert.2005.02.049","article-title":"Increased oocyte production after treatment with dehydroepiandrosterone","volume":"84","author":"Barad","year":"2005","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C179","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/humrep\/15.10.2129","article-title":"Dehydroepiandrosterone supplementation augments ovarian stimulation in poor responders: a case series","volume":"15","author":"Casson","year":"2000","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C180","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00345-003-0365-9","article-title":"Androgens and male fertility","volume":"21","author":"Dohle","year":"2003","journal-title":"World J. Urol."},{"key":"2026102020140826100_RSOB260199C181","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.3390\/ijms25115805","article-title":"Hormone regulation in testicular development and function","volume":"25","author":"Li","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C182","doi-asserted-by":"crossref","first-page":"45","DOI":"10.5534\/wjmh.180036","article-title":"Testosterone is a contraceptive and should not be used in men who desire fertility","volume":"37","author":"Patel","year":"2019","journal-title":"World J. Mens. Health"},{"key":"2026102020140826100_RSOB260199C183","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/S0022-5347(01)67482-2","article-title":"The reversibility of anabolic steroid-induced azoospermia","volume":"153","author":"Turek","year":"1995","journal-title":"J. Urol."},{"key":"2026102020140826100_RSOB260199C184","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12958-025-01442-8","article-title":"Lifestyle in flux: urbanization, dietary shifts, and endocrine health in emerging adulthood","volume":"23","author":"Joshi","year":"2025","journal-title":"Reprod. Biol. Endocrinol."},{"key":"2026102020140826100_RSOB260199C185","doi-asserted-by":"crossref","first-page":"14138","DOI":"10.3390\/ijms232214138","article-title":"Progesterone: the key factor of the beginning of life","volume":"23","author":"Bulletti","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C186","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4103\/0300-1652.107549","article-title":"Hormones in pregnancy","volume":"53","author":"Kumar","year":"2012","journal-title":"Niger. Med. J."},{"key":"2026102020140826100_RSOB260199C187","volume-title":"Diagnosis and treatment of luteal phase deficiency: a committee opinion (2021) - practice guidance","author":"American Society for Reproductive Medicine"},{"key":"2026102020140826100_RSOB260199C188","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/0002-9378(72)90181-0","article-title":"The significance of the human corpus luteum in pregnancy maintenance. I. Preliminary studies","volume":"112","author":"Csapo","year":"1972","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2026102020140826100_RSOB260199C189","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13048-015-0205-8","article-title":"Progesterone administration for luteal phase deficiency in human reproduction: an old or new issue?","volume":"8","author":"Palomba","year":"2015","journal-title":"J. Ovarian Res."},{"key":"2026102020140826100_RSOB260199C190","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1093\/humrep\/12.12.2607","article-title":"Preimplantation hormonal differences between the conception and non-conception menstrual cycles of 32 normal women","volume":"12","author":"Baird","year":"1997","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C191","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.fertnstert.2006.01.021","article-title":"A prospective study of early pregnancy loss in humans","volume":"86","author":"Vitzthum","year":"2006","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C192","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1210\/jcem-72-4-793","article-title":"Hormonal profiles of natural conception cycles ending in early, unrecognized pregnancy loss","volume":"72","author":"Baird","year":"1991","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C193","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0015-0282(97)80066-0","article-title":"Unexplained infertility: evaluation of the luteal phase; results of the National Center for Infertility Research at Michigan","volume":"67","author":"Blacker","year":"1997","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C194","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00003081-199103000-00018","article-title":"The prevalence and epidemiology of luteal-phase deficiency in normal and infertile women","volume":"34","author":"Olive","year":"1991","journal-title":"Clin. Obstet. Gynecol."},{"key":"2026102020140826100_RSOB260199C195","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1136\/bmj.1.4819.1073","article-title":"Progesterone implantation in habitual abortion","volume":"1","author":"Swyer","year":"1953","journal-title":"Br. Med. J."},{"key":"2026102020140826100_RSOB260199C196","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0015-0282(16)37260-0","article-title":"Hormonal findings in association with abnormal corpus luteum function in the human: the luteal phase defect","volume":"21","author":"Jones","year":"1970","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C197","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/00001703-199110000-00003","article-title":"Luteal phase defect","volume":"3","author":"Jones","year":"1991","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"2026102020140826100_RSOB260199C198","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1210\/jcem-30-2-246","article-title":"The short luteal phase","volume":"30","author":"Strott","year":"1970","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C199","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S0015-0282(16)56279-7","article-title":"Altered luteinizing hormone pulse frequency in early follicular phase of the menstrual cycle with luteal phase defect patients in women","volume":"60","author":"Suh","year":"1993","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C200","first-page":"359","article-title":"Superovulation of habitual aborters with subtle luteal phase deficiency","volume":"32","author":"Muechler","year":"1987","journal-title":"Int. J. Fertil."},{"key":"2026102020140826100_RSOB260199C201","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.fertnstert.2021.02.010","article-title":"Diagnosis and treatment of luteal phase deficiency: a committee opinion","volume":"115","author":"Practice Committees of the American Society for Reproductive Medicine and the Society for Reproductive Endocrinology and Infertility","year":"2021","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C202","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2165\/00007256-199825060-00003","article-title":"Sex steroid metabolism and menstrual irregularities in the exercising female. A review","volume":"25","author":"De Cr\u00e9e","year":"1998","journal-title":"Sports Med."},{"key":"2026102020140826100_RSOB260199C203","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1210\/jc.2002-020958","article-title":"Luteal phase deficiency in recreational runners: evidence for a hypometabolic state","volume":"88","author":"De Souza","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C204","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.1210\/jc.2003-032007","article-title":"Fasting ghrelin levels in physically active women: relationship with menstrual disturbances and metabolic hormones","volume":"89","author":"De Souza","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C205","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0039-128X(98)00037-3","article-title":"Regulation of steroid production and its function within the corpus luteum","volume":"63","author":"Wuttke","year":"1998","journal-title":"Steroids"},{"key":"2026102020140826100_RSOB260199C206","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/bmj.3.5980.405","article-title":"Gonadotrophin-releasing hormone treatment for induction of follicular maturation and ovulation in amenorrhoeic women with anorexia nervosa","volume":"3","author":"Nillius","year":"1975","journal-title":"Br. Med. J."},{"key":"2026102020140826100_RSOB260199C207","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1210\/jcem-60-6-1174","article-title":"The influence of dieting on the menstrual cycle of healthy young women","volume":"60","author":"Pirke","year":"1985","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C208","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJM198505233122103","article-title":"Induction of menstrual disorders by strenuous exercise in untrained women","volume":"312","author":"Bullen","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"2026102020140826100_RSOB260199C209","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.psyneuen.2005.07.002","article-title":"The effects of sex and hormonal status on the physiological response to acute psychosocial stress","volume":"31","author":"Kajantie","year":"2006","journal-title":"Psychoneuroendocrinology"},{"key":"2026102020140826100_RSOB260199C210","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1210\/jcem.87.5.8500","article-title":"Inadequate luteal function is the initial clinical cyclic defect in a 12-day stress model that includes a psychogenic component in the rhesus monkey","volume":"87","author":"Xiao","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C211","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1210\/jcem-72-5-965","article-title":"Endocrine response determines the clinical outcome of pulsatile gonadotropin-releasing hormone ovulation induction in different ovulatory disorders","volume":"72","author":"Filicori","year":"1991","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C212","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/bs.vh.2017.12.003","article-title":"Molecular aspects and clinical relevance of GDF9 and BMP15 in ovarian function","volume":"107","author":"Belli","year":"2018","journal-title":"Vitam. Horm."},{"key":"2026102020140826100_RSOB260199C213","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1093\/humrep\/det291","article-title":"Identification of a mutation in GDF9 as a novel cause of diminished ovarian reserve in young women","volume":"28","author":"Wang","year":"2013","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C214","first-page":"447","article-title":"GDF9 polymorphisms: influence on ovarian response in women undergoing controlled ovarian hyperstimulation","volume":"24","author":"Bilibio","year":"2020","journal-title":"JBRA Assist. Reprod."},{"key":"2026102020140826100_RSOB260199C215","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1093\/biolre\/ioag061","article-title":"Role of KIT signaling in ovarian development and function: insights from multisystem biology","volume":"114","author":"So","year":"2026","journal-title":"Biol. Reprod."},{"key":"2026102020140826100_RSOB260199C216","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1530\/REP-20-0422","article-title":"Meiosis interrupted: the genetics of female infertility via meiotic failure","volume":"161","author":"Biswas","year":"2021","journal-title":"Reproduction"},{"key":"2026102020140826100_RSOB260199C217","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s13238-020-00756-0","article-title":"Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development","volume":"11","author":"Zhao","year":"2020","journal-title":"Protein Cell"},{"key":"2026102020140826100_RSOB260199C218","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/biolre\/ioz089","article-title":"A segregating human allele of SPO11 modeled in mice disrupts timing and amounts of meiotic recombination, causing oligospermia and a decreased ovarian reserve\u2020","volume":"101","author":"Tran","year":"2019","journal-title":"Biol. Reprod."},{"key":"2026102020140826100_RSOB260199C219","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12958-023-01127-0","article-title":"Identification of compound heterozygous variants in MSH4 as a novel genetic cause of diminished ovarian reserve","volume":"21","author":"Wan","year":"2023","journal-title":"Reprod. Biol. Endocrinol."},{"key":"2026102020140826100_RSOB260199C220","doi-asserted-by":"crossref","first-page":"e70745","DOI":"10.1111\/jcmm.70745","article-title":"Mutation in MSH5 causes primary ovarian insufficiency and successful therapeutic intervention by in vitro fertilisation","volume":"30","author":"Mao","year":"2026","journal-title":"J. Cell. Mol. Med."},{"key":"2026102020140826100_RSOB260199C221","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.cub.2015.12.073","article-title":"Chromosome cohesion established by REC8-cohesin in fetal oocytes is maintained without detectable turnover in oocytes arrested for months in mice","volume":"26","author":"Burkhardt","year":"2016","journal-title":"Curr. Biol."},{"key":"2026102020140826100_RSOB260199C222","doi-asserted-by":"crossref","first-page":"105718","DOI":"10.1016\/j.ebiom.2025.105718","article-title":"CKAP5deficiency induces premature ovarian insufficiency","volume":"115","author":"Hu","year":"2025","journal-title":"eBioMedicine"},{"key":"2026102020140826100_RSOB260199C223","doi-asserted-by":"crossref","first-page":"787465","DOI":"10.1155\/2014\/787465","article-title":"Homozygous inactivating mutation in NANOS3 in two sisters with primary ovarian insufficiency","volume":"2014","author":"Santos","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"2026102020140826100_RSOB260199C224","doi-asserted-by":"crossref","first-page":"e825","DOI":"10.1038\/cddis.2013.368","article-title":"A NANOS3 mutation linked to protein degradation causes premature ovarian insufficiency","volume":"4","author":"Wu","year":"2013","journal-title":"Cell Death Dis."},{"key":"2026102020140826100_RSOB260199C225","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/humu.20904","article-title":"Fertility defects revealing germline biallelic nonsense NBN mutations","volume":"30","author":"Warcoin","year":"2009","journal-title":"Hum. Mutat."},{"key":"2026102020140826100_RSOB260199C226","doi-asserted-by":"crossref","first-page":"6505","DOI":"10.1093\/hmg\/ddv359","article-title":"Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L","volume":"24","author":"Zhou","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"2026102020140826100_RSOB260199C227","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/jmedgenet-2019-106789","article-title":"Homozygous variants in SYCP2L cause premature ovarian insufficiency","volume":"58","author":"He","year":"2021","journal-title":"J. Med. Genet."},{"key":"2026102020140826100_RSOB260199C228","doi-asserted-by":"crossref","first-page":"17890","DOI":"10.1038\/s41598-018-36275-6","article-title":"Transcriptome profiling of human oocytes experiencing recurrent total fertilization failure","volume":"8","author":"Suo","year":"2018","journal-title":"Sci. Rep."},{"key":"2026102020140826100_RSOB260199C229","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1093\/humrep\/deq180","article-title":"Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes","volume":"25","author":"Garcia-Cruz","year":"2010","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C230","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/cge.12867","article-title":"Mutations of SGO2 and CLDN14 collectively cause coincidental Perrault syndrome","volume":"91","author":"Faridi","year":"2017","journal-title":"Clin. Genet."},{"key":"2026102020140826100_RSOB260199C231","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/mgg3.345","article-title":"Functional study of a novel missense single-nucleotide variant of NUP107 in two daughters of Mexican origin with premature ovarian insufficiency","volume":"6","author":"Ren","year":"2018","journal-title":"Mol. Genet. Genomic Med."},{"key":"2026102020140826100_RSOB260199C232","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1172\/JCI83553","article-title":"A mutation in the nucleoporin-107 gene causes XX gonadal dysgenesis","volume":"125","author":"Weinberg-Shukron","year":"2015","journal-title":"J. Clin. Invest."},{"key":"2026102020140826100_RSOB260199C233","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3390\/ijms25010204","article-title":"BRCA mutations and fertility preservation","volume":"25","author":"Dias Nunes","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C234","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/s42003-025-08426-9","article-title":"Biallelic BRCA2 variants induce premature ovarian insufficiency by impaired meiotic homologous recombination","volume":"8","author":"Wu","year":"2025","journal-title":"Commun. Biol."},{"key":"2026102020140826100_RSOB260199C235","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ebiom.2019.03.075","article-title":"A truncating MEIOB mutation responsible for familial primary ovarian insufficiency abolishes its interaction with its partner SPATA22 and their recruitment to DNA double-strand breaks","volume":"42","author":"Caburet","year":"2019","journal-title":"eBioMedicine"},{"key":"2026102020140826100_RSOB260199C236","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1056\/NEJMc1310150","article-title":"Mutations in HFM1 in recessive primary ovarian insufficiency","volume":"370","author":"Wang","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"2026102020140826100_RSOB260199C237","doi-asserted-by":"crossref","DOI":"10.1093\/reprod\/xaaf023","article-title":"Mild defects in follicular development and reproductive performance in the heterozygous Hfm1 female mouse","volume":"171","author":"Bhati","year":"2026","journal-title":"Reproduction"},{"key":"2026102020140826100_RSOB260199C238","first-page":"19","article-title":"Analysis of MLH3 C2531T polymorphism in Iranian women with unexplained infertility","volume":"11","author":"Pashaiefar","year":"2013","journal-title":"Iran. J. Reprod. Med."},{"key":"2026102020140826100_RSOB260199C239","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1177\/1933719111428521","article-title":"Expression analysis of MLH3, MLH1, and MSH4 in maturation arrest","volume":"19","author":"Ferr\u00e1s","year":"2012","journal-title":"Reprod. Sci."},{"key":"2026102020140826100_RSOB260199C240","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1086\/505406","article-title":"Disruption of POF1B binding to nonmuscle actin filaments is associated with premature ovarian failure","volume":"79","author":"Lacombe","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"2026102020140826100_RSOB260199C241","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000373906","article-title":"Premature ovarian failure caused by a heterozygous missense mutation in POF1B and a reciprocal translocation 46,X,t(X;3)(q21.1;q21.3)","volume":"9","author":"Ledig","year":"2015","journal-title":"Sex. Dev."},{"key":"2026102020140826100_RSOB260199C242","first-page":"GP61","article-title":"Novel phenotype of isolated diminished ovarian reserve and new CSB-PGBD3 (ERCC6) mutations revealed by targeted next generation sequencing in a cohort of caucasian infertile women","volume":"63","author":"Heddar","year":"2019","journal-title":"EJEA"},{"key":"2026102020140826100_RSOB260199C243","doi-asserted-by":"crossref","first-page":"E1534","DOI":"10.1210\/jc.2013-1102","article-title":"Mutations in eIF4ENIF1 are associated with primary ovarian insufficiency","volume":"98","author":"Kasippillai","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C244","doi-asserted-by":"crossref","first-page":"104597","DOI":"10.1016\/j.ejmg.2022.104597","article-title":"EIF4ENIF1 variants in two patients with non-syndromic premature ovarian insufficiency","volume":"65","author":"Shang","year":"2022","journal-title":"Eur. J. Med. Genet."},{"key":"2026102020140826100_RSOB260199C245","doi-asserted-by":"crossref","first-page":"ii47","DOI":"10.1093\/humrep\/dead084","article-title":"Homozygous missense variant in MEIOSIN causes premature ovarian insufficiency","volume":"38","author":"Zhang","year":"2023","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C246","volume-title":"Ybx2","author":"Alliance of Genome Resources"},{"key":"2026102020140826100_RSOB260199C247","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s13578-024-01341-2","article-title":"PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation","volume":"14","author":"Zhang","year":"2024","journal-title":"Cell Biosci."},{"key":"2026102020140826100_RSOB260199C248","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.7150\/ijms.109085","article-title":"Novel genetic variants in PATL2 corresponding to different clinical phenotypes of female infertility","volume":"22","author":"Yang","year":"2025","journal-title":"Int. J. Med. Sci."},{"key":"2026102020140826100_RSOB260199C249","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/humupd\/dmaf023","article-title":"The intricate dance of RNA-binding proteins: unveiling the mechanisms behind male infertility","volume":"32","author":"Gao","year":"2026","journal-title":"Hum. Reprod. Update"},{"key":"2026102020140826100_RSOB260199C250","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ydbio.2005.06.032","article-title":"Dazl deficiency leads to embryonic arrest of germ cell development in XY C57BL\/6 mice","volume":"288","author":"Lin","year":"2005","journal-title":"Dev. Biol."},{"key":"2026102020140826100_RSOB260199C251","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/humrep\/11.suppl_4.27","article-title":"Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene","volume":"11","author":"Reijo","year":"1996","journal-title":"Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C252","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/37987","article-title":"The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis","volume":"389","author":"Ruggiu","year":"1997","journal-title":"Nature"},{"key":"2026102020140826100_RSOB260199C253","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ajhg.2010.09.009","article-title":"Human male infertility associated with mutations in NR5A1 encoding steroidogenic factor 1","volume":"87","author":"Bashamboo","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"2026102020140826100_RSOB260199C254","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.tig.2008.10.008","article-title":"Sex determination and SRY: down to a wink and a nudge?","volume":"25","author":"Sekido","year":"2009","journal-title":"Trends Genet."},{"key":"2026102020140826100_RSOB260199C255","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1530\/REP-08-0537","article-title":"Control of KIT signalling in male germ cells: what can we learn from other systems?","volume":"138","author":"Mithraprabhu","year":"2009","journal-title":"Reproduction"},{"key":"2026102020140826100_RSOB260199C256","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/BF03343784","article-title":"Role of c-kit in mammalian spermatogenesis","volume":"23","author":"Rossi","year":"2000","journal-title":"J. Endocrinol. Invest."},{"key":"2026102020140826100_RSOB260199C257","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1172\/JCI96794","article-title":"Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis","volume":"128","author":"Oduwole","year":"2018","journal-title":"J. Clin. Invest."},{"key":"2026102020140826100_RSOB260199C258","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/receptors4030016","article-title":"The state-of-the-art review on FSHR, LHCGR, AR, ESR1, and ESR2 key mutations and their impact on the effectiveness of infertility therapies\u2014what we know so far","volume":"4","author":"Hristov","year":"2025","journal-title":"Receptors"},{"key":"2026102020140826100_RSOB260199C259","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1056\/NEJM199506013322204","article-title":"Mutations in the cystic fibrosis gene in patients with congenital absence of the vas deferens","volume":"332","author":"Chill\u00f3n","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"2026102020140826100_RSOB260199C260","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ydbio.2007.02.025","article-title":"Conversion of midbodies into germ cell intercellular bridges","volume":"305","author":"Greenbaum","year":"2007","journal-title":"Dev. Biol."},{"key":"2026102020140826100_RSOB260199C261","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.ajhg.2016.08.004","article-title":"Biallelic SUN5 mutations cause autosomal-recessive acephalic spermatozoa syndrome","volume":"99","author":"Zhu","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"2026102020140826100_RSOB260199C262","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12958-025-01497-7","article-title":"Genetic and epigenetic insights into non-obstructive azoospermia: mechanisms, biomarkers, and clinical perspectives","volume":"23","author":"Wang","year":"2025","journal-title":"Reprod. Biol. Endocrinol."},{"key":"2026102020140826100_RSOB260199C263","doi-asserted-by":"crossref","first-page":"662770","DOI":"10.3389\/fgene.2021.662770","article-title":"A catalog of human genes associated with pathozoospermia and functional characteristics of these genes","volume":"12","author":"Ignatieva","year":"2021","journal-title":"Front. Genet."},{"key":"2026102020140826100_RSOB260199C264","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/0886022X.2016.1274661","article-title":"The SPO11-C631T gene polymorphism and male infertility risk: a meta-analysis","volume":"39","author":"Ren","year":"2017","journal-title":"Ren. Fail."},{"key":"2026102020140826100_RSOB260199C265","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/j.scib.2020.08.026","article-title":"A TOP6BL mutation abolishes meiotic DNA double-strand break formation and causes human infertility","volume":"65","author":"Jiao","year":"2020","journal-title":"Sci. Bull. (Beijing)"},{"key":"2026102020140826100_RSOB260199C266","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/mutage\/geab010","article-title":"Mlh1 heterozygosity and promoter methylation associates with microsatellite instability in mouse sperm","volume":"36","author":"Shrestha","year":"2021","journal-title":"Mutagenesis"},{"key":"2026102020140826100_RSOB260199C267","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/19396360802061317","article-title":"Analysis of the meiotic recombination gene REC8 for sequence variations in a population with severe male factor infertility","volume":"54","author":"Griffin","year":"2008","journal-title":"Syst. Biol. Reprod. Med."},{"key":"2026102020140826100_RSOB260199C268","doi-asserted-by":"crossref","first-page":"e28199","DOI":"10.7554\/eLife.28199","article-title":"Essential role for SUN5 in anchoring sperm head to the tail","volume":"6","author":"Shang","year":"2017","journal-title":"eLife"},{"key":"2026102020140826100_RSOB260199C269","doi-asserted-by":"crossref","first-page":"e2520626123","DOI":"10.1073\/pnas.2520626123","article-title":"SUN5 forms a regular protein lattice reinforcing the sperm head-tail junction","volume":"123","author":"Moecking","year":"2026","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2026102020140826100_RSOB260199C270","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4103\/aja.aja_79_18","article-title":"Novel DPY19L2 variants in globozoospermic patients and the overcoming this male infertility","volume":"21","author":"Shang","year":"2019","journal-title":"Asian J. Androl."},{"key":"2026102020140826100_RSOB260199C271","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.3390\/ijms20051163","article-title":"Testis-specific SEPT12 expression affects SUN protein localization and is involved in mammalian spermiogenesis","volume":"20","author":"Yeh","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C272","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/molehr\/gar050","article-title":"A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis","volume":"17","author":"Ben Khelifa","year":"2011","journal-title":"Mol. Hum. Reprod."},{"key":"2026102020140826100_RSOB260199C273","doi-asserted-by":"crossref","first-page":"26334941251399074","DOI":"10.1177\/26334941251399074","article-title":"A focused evaluation of genetic and epigenetic contributions to common infertility conditions","volume":"19","author":"Gunes","year":"2025","journal-title":"Ther. Adv. Reprod. Health"},{"key":"2026102020140826100_RSOB260199C274","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/epigenomes8030034","article-title":"Decoding the epigenetics of infertility: mechanisms, environmental influences, and therapeutic strategies","volume":"8","author":"Safti\u0107 Martinovi\u0107","year":"2024","journal-title":"Epigenomes"},{"key":"2026102020140826100_RSOB260199C275","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3390\/ijms24010004","article-title":"Translational bioinformatics for human reproductive biology research: examples, opportunities and challenges for a future reproductive medicine","volume":"24","author":"Liu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C276","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ando.2022.06.001","article-title":"Turner syndrome and fertility","volume":"83","author":"Viuf","year":"2022","journal-title":"Ann. Endocrinol ."},{"key":"2026102020140826100_RSOB260199C277","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/MED.0000000000000784","article-title":"Turner syndrome: fertility counselling in childhood and through the reproductive lifespan","volume":"30","author":"Bollig","year":"2023","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"2026102020140826100_RSOB260199C278","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12920-022-01320-x","article-title":"Candidate genes for infertility: an in-silico study based on cytogenetic analysis","volume":"15","author":"Sahota","year":"2022","journal-title":"BMC Med. Genomics"},{"key":"2026102020140826100_RSOB260199C279","first-page":"14634","article-title":"Y chromosome azoospermia factor region microdeletions and transmission characteristics in azoospermic and severe oligozoospermic patients","volume":"8","author":"Yu","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"2026102020140826100_RSOB260199C280","first-page":"253","article-title":"Y choromosomal microdeletion screening in the workup of male infertility and its current status in India","volume":"7","author":"Suganthi","year":"2014","journal-title":"Int. J. Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C281","first-page":"936569","article-title":"Genetic dissection of the AZF regions of the human Y chromosome: thriller or filler for male (in)fertility?","author":"Navarro-Costa","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"2026102020140826100_RSOB260199C282","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4103\/1008-682X.172827","article-title":"Y-chromosome microdeletions in nonobstructive azoospermia and severe oligozoospermia","volume":"19","author":"Goncalves","year":"2017","journal-title":"Asian J. Androl."},{"key":"2026102020140826100_RSOB260199C283","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/rmb2.12336","article-title":"Genetic disorders and male infertility","volume":"19","author":"Kuroda","year":"2020","journal-title":"Reprod. Med. Biol."},{"key":"2026102020140826100_RSOB260199C284","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bpobgyn.2017.05.002","article-title":"Genetic diagnostics of male infertility in clinical practice","volume":"44","author":"Flannigan","year":"2017","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"2026102020140826100_RSOB260199C285","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.3390\/ijms21155274","article-title":"External and genetic conditions determining male infertility","volume":"21","author":"Kami\u0144ski","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C286","doi-asserted-by":"crossref","first-page":"104311","DOI":"10.1016\/j.jri.2024.104311","article-title":"Epigenetic modifications during embryonic development: gene reprogramming and regulatory networks","volume":"165","author":"Tang","year":"2024","journal-title":"J. Reprod. Immunol."},{"key":"2026102020140826100_RSOB260199C287","doi-asserted-by":"crossref","first-page":"jkag027","DOI":"10.1093\/g3journal\/jkag027","article-title":"Genetic identification of Pid3-1 and its regulatory role in promoting blast resistance in rice","volume":"16","author":"Liu","year":"2026","journal-title":"G3"},{"key":"2026102020140826100_RSOB260199C288","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.3390\/ijms27031353","article-title":"From genes to lives: integrating the complexities of primary ovarian insufficiency","volume":"27","author":"Abujaber","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C289","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00404-025-08048-w","article-title":"DNA methylation and its impact on ovarian steroidogenesis in women with polycystic ovary syndrome: insights from human and animal models","volume":"312","author":"Zhong","year":"2025","journal-title":"Arch. Gynecol. Obstet."},{"key":"2026102020140826100_RSOB260199C290","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3390\/biomedicines13030730","article-title":"Epigenetic alterations in ovarian function and their impact on assisted reproductive technologies: a systematic review","volume":"13","author":"Voros","year":"2025","journal-title":"Biomedicines"},{"key":"2026102020140826100_RSOB260199C291","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s40246-024-00626-4","article-title":"Sperm epigenetics and male infertility: unraveling the molecular puzzle","volume":"18","author":"Hosseini","year":"2024","journal-title":"Hum. Genomics"},{"key":"2026102020140826100_RSOB260199C292","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/andr.12001","article-title":"Sperm global DNA methylation level: association with semen parameters and genome integrity","volume":"3","author":"Montjean","year":"2015","journal-title":"Andrology"},{"key":"2026102020140826100_RSOB260199C293","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1186\/s12864-019-6317-6","article-title":"Epigenetic analysis of high and low motile sperm populations reveals methylation variation in satellite regions within the pericentromeric position and in genes functionally related to sperm DNA organization and maintenance in Bos taurus","volume":"20","author":"Capra","year":"2019","journal-title":"BMC Genomics"},{"key":"2026102020140826100_RSOB260199C294","doi-asserted-by":"crossref","first-page":"689624","DOI":"10.3389\/fcell.2021.689624","article-title":"Epigenetics of male infertility: the role of DNA methylation","volume":"9","author":"Rotondo","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"2026102020140826100_RSOB260199C295","doi-asserted-by":"crossref","first-page":"53804","DOI":"10.18632\/oncotarget.17479","article-title":"Epigenetic dynamics and interplay during spermatogenesis and embryogenesis: implications for male fertility and offspring health","volume":"8","author":"Ge","year":"2017","journal-title":"Oncotarget"},{"key":"2026102020140826100_RSOB260199C296","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mrrev.2011.04.002","article-title":"Epigenetics, spermatogenesis and male infertility","volume":"727","author":"Rajender","year":"2011","journal-title":"Mutat. Res."},{"key":"2026102020140826100_RSOB260199C297","doi-asserted-by":"crossref","first-page":"1123975","DOI":"10.3389\/fcell.2023.1123975","article-title":"Behind the scenes: how RNA orchestrates the epigenetic regulation of gene expression","volume":"11","author":"Mangiavacchi","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"2026102020140826100_RSOB260199C298","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.3390\/jcm9082520","article-title":"Environmental impact on male (in)fertility via epigenetic route","volume":"9","author":"Cescon","year":"2020","journal-title":"J. Clin. Med."},{"key":"2026102020140826100_RSOB260199C299","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/s41586-024-07472-3","article-title":"Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs","volume":"630","author":"Tomar","year":"2024","journal-title":"Nature"},{"key":"2026102020140826100_RSOB260199C300","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.3390\/biomedicines10092184","article-title":"Methods for assessing oocyte quality: a review of literature","volume":"10","author":"Lemseffer","year":"2022","journal-title":"Biomedicines"},{"key":"2026102020140826100_RSOB260199C301","doi-asserted-by":"crossref","first-page":"1411000","DOI":"10.3389\/fendo.2024.1411000","article-title":"Calcium signaling in oocyte quality and functionality and its application","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Endocrinol."},{"key":"2026102020140826100_RSOB260199C302","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.3390\/ijms23052880","article-title":"Chromosome segregation in the oocyte: what goes wrong during aging","volume":"23","author":"Wasielak-Politowska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C303","doi-asserted-by":"crossref","first-page":"101012","DOI":"10.1016\/j.xgen.2025.101012","article-title":"Genetic landscape of human oocyte\/embryo defects","volume":"6","author":"Chen","year":"2026","journal-title":"Cell Genomics"},{"key":"2026102020140826100_RSOB260199C304","first-page":"8","article-title":"Semen analysis is the cornerstone of investigation for male infertility","volume":"251","author":"Barratt","year":"2007","journal-title":"Practitioner"},{"key":"2026102020140826100_RSOB260199C305","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/0970-1591.78424","article-title":"Semen analysis and sperm function tests: how much to test?","volume":"27","author":"Vasan","year":"2011","journal-title":"Indian J. Urol."},{"key":"2026102020140826100_RSOB260199C306","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.5713\/ab.21.0072","article-title":"Semen evaluation: methodological advancements in sperm quality-specific fertility assessment\u2014a review","volume":"34","author":"Tanga","year":"2021","journal-title":"Anim. Biosci."},{"key":"2026102020140826100_RSOB260199C307","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-1-62703-038-0_10","article-title":"The sperm penetration assay for the assessment of fertilization capacity","volume":"927","author":"Hwang","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"2026102020140826100_RSOB260199C308","doi-asserted-by":"crossref","first-page":"100","DOI":"10.12750\/JARB.34.2.100","article-title":"Effect of extenders with TCG and DMSO on the viability of rabbit sperm","volume":"34","author":"Eo","year":"2019","journal-title":"J. Anim. Reprod. Biotechnol."},{"key":"2026102020140826100_RSOB260199C309","doi-asserted-by":"crossref","first-page":"e13615","DOI":"10.1111\/and.13615","article-title":"How defective spermatogenesis affects sperm DNA integrity","volume":"53","author":"Kuchakulla","year":"2021","journal-title":"Andrologia"},{"key":"2026102020140826100_RSOB260199C310","doi-asserted-by":"crossref","first-page":"1530972","DOI":"10.3389\/fendo.2024.1530972","article-title":"Impact of sperm DNA fragmentation index on assisted reproductive outcomes: a retrospective analysis","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Endocrinol."},{"key":"2026102020140826100_RSOB260199C311","doi-asserted-by":"crossref","first-page":"103773","DOI":"10.1016\/j.rbmo.2023.103773","article-title":"Prospective reproductive outcomes according to sperm parameters, including DNA fragmentation, in recurrent pregnancy loss","volume":"49","author":"Krog","year":"2024","journal-title":"Reprod. Biomed. Online"},{"key":"2026102020140826100_RSOB260199C312","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1111\/1471-0528.17796","article-title":"Quantifying the association of sperm DNA fragmentation with assisted reproductive technology outcomes: an umbrella review","volume":"131","author":"Maghraby","year":"2024","journal-title":"BJOG"},{"key":"2026102020140826100_RSOB260199C313","doi-asserted-by":"crossref","first-page":"e20749","DOI":"10.7717\/peerj.20749","article-title":"Sperm chromatin condensation defects and IVF outcomes: a retrospective cohort study","volume":"14","author":"Zhou","year":"2026","journal-title":"PeerJ"},{"key":"2026102020140826100_RSOB260199C314","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.fertnstert.2008.01.063","article-title":"Influence of sperm chromatin anomalies on assisted reproductive technology outcome","volume":"91","author":"Tavalaee","year":"2009","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C315","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13072-018-0224-y","article-title":"Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development","volume":"11","author":"Wyck","year":"2018","journal-title":"Epigenetics Chromatin"},{"key":"2026102020140826100_RSOB260199C316","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.1016\/j.celrep.2018.05.094","article-title":"Re-evaluating the localization of sperm-retained histones revealed the modification-dependent accumulation in specific genome regions","volume":"23","author":"Yamaguchi","year":"2018","journal-title":"Cell Rep."},{"key":"2026102020140826100_RSOB260199C317","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.3390\/cells14231886","article-title":"New evidence in male infertility diagnosis: the role of metabolomics","volume":"14","author":"Peluso","year":"2025","journal-title":"Cells"},{"key":"2026102020140826100_RSOB260199C318","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3390\/cimb48010117","article-title":"Seminal plasma and extracellular vesicles as molecular gatekeepers: oxidative stress, endocrine crosstalk, and biomarker discovery in male infertility","volume":"48","author":"Sengupta","year":"2026","journal-title":"Curr. Issues Mol. Biol."},{"key":"2026102020140826100_RSOB260199C319","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11934-018-0810-3","article-title":"Use of ultrasound in male infertility: appropriate selection of men for scrotal ultrasound","volume":"19","author":"Armstrong","year":"2018","journal-title":"Curr. Urol. Rep."},{"key":"2026102020140826100_RSOB260199C320","first-page":"e50048","article-title":"Role of transvaginal sonography in the diagnosis of female infertility: a comprehensive review","volume":"15","author":"Thaker","year":"2023","journal-title":"Cureus"},{"key":"2026102020140826100_RSOB260199C321","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/GRF.0000000000000263","article-title":"Ultrasound in infertility treatments","volume":"60","author":"Klenov","year":"2017","journal-title":"Clin. Obstet. Gynecol."},{"key":"2026102020140826100_RSOB260199C322","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF02924590","article-title":"Infertility diagnosis by ultrasound","volume":"13","author":"Sanders","year":"1991","journal-title":"Urol. Radiol."},{"key":"2026102020140826100_RSOB260199C323","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1148\/radiol.2331020777","article-title":"Mullerian duct anomalies: imaging and clinical issues","volume":"233","author":"Troiano","year":"2004","journal-title":"Radiology"},{"key":"2026102020140826100_RSOB260199C324","volume-title":"Ultrasound Journal 39\u2014ultrasonic diagnosis of M\u00fcllerian duct anomalies","author":"Mindray"},{"key":"2026102020140826100_RSOB260199C325","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s43032-023-01318-5","article-title":"Understanding ultrasound features that predict symptom severity in patients with adenomyosis: a systematic review","volume":"31","author":"Kobayashi","year":"2024","journal-title":"Reprod. Sci."},{"key":"2026102020140826100_RSOB260199C326","doi-asserted-by":"crossref","first-page":"102286","DOI":"10.1016\/j.jvsv.2025.102286","article-title":"Transvaginal ultrasound approach for diagnosing pelvic venous disorders","volume":"13","author":"Fernandes","year":"2025","journal-title":"J. Vasc. Surg. Venous Lymphat. Disord."},{"key":"2026102020140826100_RSOB260199C327","first-page":"CD005289","article-title":"Monitoring of stimulated cycles in assisted reproduction (IVF and ICSI)","author":"Kwan","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"2026102020140826100_RSOB260199C328","doi-asserted-by":"crossref","first-page":"G43","DOI":"10.1093\/ejendo\/lvad096","article-title":"Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"189","author":"Teede","year":"2023","journal-title":"Eur. J. Endocrinol."},{"key":"2026102020140826100_RSOB260199C329","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1017\/9781108149877","volume-title":"Gynaecological ultrasound scanning: tips and tricks","author":"Jayaprakasan","year":"2020"},{"key":"2026102020140826100_RSOB260199C330","first-page":"58","article-title":"Doppler ultrasound investigation of female infertility","volume":"66","author":"Choi","year":"2023","journal-title":"Obstet. Gynecol. Sci."},{"key":"2026102020140826100_RSOB260199C331","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4103\/jhrs.JHRS_47_18","article-title":"Role of saline infusion sonohysterography in infertility evaluation","volume":"11","author":"Singh","year":"2018","journal-title":"J. Hum. Reprod. Sci."},{"key":"2026102020140826100_RSOB260199C332","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1046\/j.1469-0705.1994.04030245.x","article-title":"Hysterosalpingo contrast sonography (HyCoSy) and its future role within the investigation of infertility in Europe","volume":"4","author":"Campbell","year":"1994","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"2026102020140826100_RSOB260199C333","doi-asserted-by":"crossref","first-page":"931","DOI":"10.12669\/pjms.39.4.7462","article-title":"The diagnostic value of hysterosalpingo-contrast sonography in female infertility of the fallopian tube","volume":"39","author":"Li","year":"2023","journal-title":"Pak. J. Med. Sci."},{"key":"2026102020140826100_RSOB260199C334","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1155\/2015\/306248","article-title":"Comparison of four different pain relief methods during hysterosalpingography: a randomized controlled study","volume":"20","author":"Unlu","year":"2015","journal-title":"Pain Res. Manag."},{"key":"2026102020140826100_RSOB260199C335","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2214\/AJR.11.7789","article-title":"MRI of pregnancy-related issues: M\u00fcllerian duct anomalies","volume":"198","author":"Robbins","year":"2012","journal-title":"AJR Am. J. Roentgenol."},{"key":"2026102020140826100_RSOB260199C336","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13244-021-01054-x","article-title":"Magnetic resonance imaging for deep infiltrating endometriosis: current concepts, imaging technique and key findings","volume":"12","author":"Lorusso","year":"2021","journal-title":"Insights Imaging"},{"key":"2026102020140826100_RSOB260199C337","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s13244-017-0576-z","article-title":"MRI for adenomyosis: a pictorial review","volume":"8","author":"Agostinho","year":"2017","journal-title":"Insights Imaging"},{"key":"2026102020140826100_RSOB260199C338","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1053\/j.ro.2017.04.003","article-title":"Magnetic resonance imaging of soft tissue masses","volume":"52","author":"Fain","year":"2017","journal-title":"Semin. Roentgenol."},{"key":"2026102020140826100_RSOB260199C339","doi-asserted-by":"crossref","first-page":"180","DOI":"10.14366\/usg.15075","article-title":"Ultrasonography of the scrotum in adults","volume":"35","author":"K\u00fchn","year":"2016","journal-title":"Ultrasonography"},{"key":"2026102020140826100_RSOB260199C340","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1055\/s-0036-1586143","article-title":"The varicocele: clinical presentation, evaluation, and surgical management","volume":"33","author":"Lomboy","year":"2016","journal-title":"Semin. Intervent. Radiol."},{"key":"2026102020140826100_RSOB260199C341","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1148\/radiographics.11.6.1749858","article-title":"Color Doppler US of the scrotum","volume":"11","author":"Horstman","year":"1991","journal-title":"Radiographics"},{"key":"2026102020140826100_RSOB260199C342","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1148\/radiology.175.3.2188301","article-title":"Suspected testicular torsion and ischemia: evaluation with color Doppler sonography","volume":"175","author":"Burks","year":"1990","journal-title":"Radiology"},{"key":"2026102020140826100_RSOB260199C343","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1148\/radiology.177.1.2204963","article-title":"Acute scrotal disorders: prospective comparison of color Doppler US and testicular scintigraphy","volume":"177","author":"Middleton","year":"1990","journal-title":"Radiology"},{"key":"2026102020140826100_RSOB260199C344","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2214\/ajr.163.3.8079863","article-title":"Color Doppler sonography of the scrotum in children","volume":"163","author":"Luker","year":"1994","journal-title":"AJR Am. J. Roentgenol."},{"key":"2026102020140826100_RSOB260199C345","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0022-5347(17)49385-2","article-title":"Vasography: effect of various agents on vas deferens patency","volume":"133","author":"Bertram","year":"1985","journal-title":"J. Urol."},{"key":"2026102020140826100_RSOB260199C346","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1259\/bjr\/31818161","article-title":"Male infertility: the role of imaging in diagnosis and management","volume":"85","author":"Ammar","year":"2012","journal-title":"Br. J. Radiol."},{"key":"2026102020140826100_RSOB260199C347","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1148\/radiology.205.1.9314999","article-title":"Transrectal US-guided seminal vesiculography","volume":"205","author":"Jones","year":"1997","journal-title":"Radiology"},{"key":"2026102020140826100_RSOB260199C348","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1259\/imaging\/67168161","article-title":"Male infertility: role of imaging in the diagnosis and management","volume":"20","author":"Edey","year":"2008","journal-title":"Imaging"},{"key":"2026102020140826100_RSOB260199C349","doi-asserted-by":"crossref","first-page":"907","DOI":"10.4103\/1008-682X.142768","article-title":"The performance of transrectal ultrasound in the diagnosis of seminal vesicle defects: a comparison with magnetic resonance imaging","volume":"16","author":"Chen","year":"2014","journal-title":"Asian J. Androl."},{"key":"2026102020140826100_RSOB260199C350","doi-asserted-by":"crossref","first-page":"825","DOI":"10.7863\/jum.2006.25.7.825","article-title":"Role of transrectal ultrasonography in the evaluation of azoospermic men with low-volume ejaculate","volume":"25","author":"Raviv","year":"2006","journal-title":"J. Ultrasound Med."},{"key":"2026102020140826100_RSOB260199C351","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/S0022-5347(17)36387-5","article-title":"Transrectal ultrasound in the evaluation of men with low volume azoospermia","volume":"149","author":"Worischeck","year":"1993","journal-title":"J. Urol."},{"key":"2026102020140826100_RSOB260199C352","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0015-0282(16)56406-1","article-title":"Transrectal ultrasonography of infertile men","volume":"60","author":"Jarow","year":"1993","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C353","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0022-5347(17)39455-7","article-title":"Transrectal prostate ultrasonography as a diagnostic and therapeutic aid for ejaculatory duct obstruction","volume":"144","author":"Belker","year":"1990","journal-title":"J. Urol."},{"key":"2026102020140826100_RSOB260199C354","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0090-4295(92)90245-R","article-title":"Transrectal ultrasound and partial ejaculatory duct obstruction in male infertility","volume":"39","author":"Hellerstein","year":"1992","journal-title":"Urology"},{"key":"2026102020140826100_RSOB260199C355","doi-asserted-by":"crossref","first-page":"11057","DOI":"10.3390\/ijms262211057","article-title":"The role of cytokines in the development and functioning of the hypothalamic-pituitary-gonadal axis in mammals in normal and pathological conditions","volume":"26","author":"Ignatiuk","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C356","doi-asserted-by":"crossref","first-page":"BSR20231916","DOI":"10.1042\/BSR20231916","article-title":"Metabolic hormones are integral regulators of female reproductive health and function","volume":"44","author":"Athar","year":"2024","journal-title":"Biosci. Rep."},{"key":"2026102020140826100_RSOB260199C357","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1210\/clinem\/dgaf524","article-title":"Multiracial cytokine profiling reveals immune dysregulation not chronic inflammation in polycystic ovary syndrome","volume":"111","author":"Pacheco-Sanchez","year":"2026","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C358","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3390\/diagnostics16040527","article-title":"Oxidative stress and inflammatory biomarkers in male infertility: a narrative review of diagnostic value and clinical integration","volume":"16","author":"Zikopoulos","year":"2026","journal-title":"Diagnostics (Basel)"},{"key":"2026102020140826100_RSOB260199C359","doi-asserted-by":"crossref","first-page":"e240197","DOI":"10.1530\/REP-24-0197","article-title":"The effect of chronic inflammation on female fertility","volume":"169","author":"Ameho","year":"2025","journal-title":"Reproduction"},{"key":"2026102020140826100_RSOB260199C360","doi-asserted-by":"crossref","first-page":"e12598","DOI":"10.1002\/rmb2.12598","article-title":"Oxidative stress affects sperm health and fertility-time to apply facts learned at the bench to help the patient: lessons for busy clinicians","volume":"23","author":"Sengupta","year":"2024","journal-title":"Reprod. Med. Biol."},{"key":"2026102020140826100_RSOB260199C361","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.3390\/ijms221810043","article-title":"Oxidative stress, testicular inflammatory pathways, and male reproduction","volume":"22","author":"Dutta","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C362","doi-asserted-by":"crossref","first-page":"1520835","DOI":"10.3389\/fendo.2025.1520835","article-title":"Mechanisms of oxidative stress-induced sperm dysfunction","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"2026102020140826100_RSOB260199C363","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1073\/pnas.1017213108","article-title":"Reactive oxygen species are indispensable in ovulation","volume":"108","author":"Shkolnik","year":"2011","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2026102020140826100_RSOB260199C364","article-title":"Oxidative stress impact on female reproductive health","author":"Nature Index","year":"2026"},{"key":"2026102020140826100_RSOB260199C365","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3389\/fendo.2019.00811","article-title":"Impact of oxidative stress on age-associated decline in oocyte developmental competence","volume":"10","author":"Sasaki","year":"2019","journal-title":"Front. Endocrinol."},{"key":"2026102020140826100_RSOB260199C366","doi-asserted-by":"crossref","first-page":"e14338","DOI":"10.1111\/acel.14338","article-title":"Oocytes maintain low ROS levels to support the dormancy of primordial follicles","volume":"24","author":"Qin","year":"2025","journal-title":"Aging Cell"},{"key":"2026102020140826100_RSOB260199C367","doi-asserted-by":"crossref","first-page":"e2302887","DOI":"10.1002\/advs.202302887","article-title":"Excessive lipid peroxidation in uterine epithelium causes implantation failure and pregnancy loss","volume":"11","author":"Lu","year":"2024","journal-title":"Adv. Sci. (Weinh)."},{"key":"2026102020140826100_RSOB260199C368","doi-asserted-by":"crossref","first-page":"100469","DOI":"10.1016\/j.metop.2026.100469","article-title":"Influence of metabolic syndrome on infertility: a review","volume":"30","author":"Tesfa","year":"2026","journal-title":"Metab. Open"},{"key":"2026102020140826100_RSOB260199C369","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.metabol.2012.08.012","article-title":"The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative review","volume":"62","author":"Michalakis","year":"2013","journal-title":"Metab. Clin. Exp."},{"key":"2026102020140826100_RSOB260199C370","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/oby.20077","article-title":"Liver fat and SHBG affect insulin resistance in midlife women: the Study of Women's Health Across the Nation (SWAN)","volume":"21","author":"Kavanagh","year":"2013","journal-title":"Obesity"},{"key":"2026102020140826100_RSOB260199C371","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1095\/biolreprod.111.092593","article-title":"Diverse roles for sex hormone-binding globulin in reproduction","volume":"85","author":"Hammond","year":"2011","journal-title":"Biol. Reprod."},{"key":"2026102020140826100_RSOB260199C372","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/obr.12282","article-title":"Testosterone and obesity","volume":"16","author":"Kelly","year":"2015","journal-title":"Obes. Rev."},{"key":"2026102020140826100_RSOB260199C373","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1530\/EJE-12-0955","article-title":"Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis","volume":"168","author":"Corona","year":"2013","journal-title":"Eur. J. Endocrinol."},{"key":"2026102020140826100_RSOB260199C374","doi-asserted-by":"crossref","first-page":"e240269","DOI":"10.1530\/JOE-24-0269","article-title":"Reappraising the relationship between hyperinsulinemia and insulin resistance in PCOS","volume":"265","author":"Houston","year":"2025","journal-title":"J. Endocrinol."},{"key":"2026102020140826100_RSOB260199C375","doi-asserted-by":"crossref","DOI":"10.1186\/s13048-026-02017-w","article-title":"Mechanisms and clinical implications of oxidative stress-mediated endometrial receptivity impairment in polycystic ovary syndrome","volume":"19","author":"Hou","year":"2026","journal-title":"J. Ovarian Res."},{"key":"2026102020140826100_RSOB260199C376","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s12522-014-0194-0","article-title":"Regulation of gonadotropin secretion by monitoring energy availability","volume":"14","author":"Matsuyama","year":"2015","journal-title":"Reprod. Med. Biol."},{"key":"2026102020140826100_RSOB260199C377","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.3390\/ijms20184440","article-title":"The insulin\/IGF system in mammalian sexual development and reproduction","volume":"20","author":"Neirijnck","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C378","doi-asserted-by":"crossref","first-page":"6833","DOI":"10.3390\/ijms26146833","article-title":"Role of AMP-activated protein kinase (AMPK) in female reproduction: a review","volume":"26","author":"Kamar Bashah","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C379","doi-asserted-by":"crossref","first-page":"808","DOI":"10.3390\/cells15090808","article-title":"Targeting AMPK networks for male reproductive health: mechanisms and emerging therapies","volume":"15","author":"Rahman","year":"2026","journal-title":"Cells"},{"key":"2026102020140826100_RSOB260199C380","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3389\/fendo.2019.00692","article-title":"Role of mTOR signaling in female reproduction","volume":"10","author":"Guo","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026102020140826100_RSOB260199C381","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.3390\/ijms20071633","article-title":"Molecular mechanisms controlled by mTOR in male reproductive system","volume":"20","author":"Moreira","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C382","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.theriogenology.2024.12.026","article-title":"Role of PI3K\/AKT signaling pathway during capacitation","volume":"235","author":"Lee","year":"2025","journal-title":"Theriogenology"},{"key":"2026102020140826100_RSOB260199C383","doi-asserted-by":"crossref","first-page":"E1247","DOI":"10.1152\/ajpendo.00274.2009","article-title":"Recent advances in understanding leptin signaling and leptin resistance","volume":"297","author":"Morris","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2026102020140826100_RSOB260199C384","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3390\/genes12040475","article-title":"TERRA: a novel biomarker of embryo quality and art outcome","volume":"12","author":"Rocca","year":"2021","journal-title":"Genes"},{"key":"2026102020140826100_RSOB260199C385","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3390\/genes14020425","article-title":"Telomere length, a new biomarker of male (in)fertility? A systematic review of the literature","volume":"14","author":"Fattet","year":"2023","journal-title":"Genes"},{"key":"2026102020140826100_RSOB260199C386","doi-asserted-by":"crossref","first-page":"1657744","DOI":"10.3389\/fcell.2025.1657744","article-title":"Cracking the code: how piRNA pathway shapes spermatogenesis and combats male infertility","volume":"13","author":"Hong","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"2026102020140826100_RSOB260199C387","doi-asserted-by":"crossref","first-page":"24229","DOI":"10.1038\/srep24229","article-title":"Systematic characterization of seminal plasma piRNAs as molecular biomarkers for male infertility","volume":"6","author":"Hong","year":"2016","journal-title":"Sci. Rep."},{"key":"2026102020140826100_RSOB260199C388","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.3390\/ijms24065447","article-title":"Using small non-coding RNAs in extracellular vesicles of semen as biomarkers of male reproductive system health: opportunities and challenges","volume":"24","author":"Larriba","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C389","doi-asserted-by":"crossref","first-page":"12979","DOI":"10.3390\/ijms252312979","article-title":"Micrornas as biomarkers and therapeutic targets in female infertility","volume":"25","author":"Chico-Sordo","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C390","doi-asserted-by":"crossref","first-page":"9499","DOI":"10.3390\/ijms26199499","article-title":"Serum VEGF potential as a biomarker for diagnosis of female unexplained infertility: does atopy matter?","volume":"26","author":"Did\u017eiokait\u0117","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"2026102020140826100_RSOB260199C391","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/14789450.2023.2275683","article-title":"Proteomics in the study of female fertility: an update","volume":"20","author":"Kanaka","year":"2023","journal-title":"Expert Rev. Proteomics"},{"key":"2026102020140826100_RSOB260199C392","doi-asserted-by":"crossref","first-page":"11832","DOI":"10.1021\/acs.analchem.4c01494","article-title":"Quantitative proteomics and metabolomics of culture medium from single Human embryo reveal embryo quality-related multiomics biomarkers","volume":"96","author":"Deng","year":"2024","journal-title":"Anal. Chem."},{"key":"2026102020140826100_RSOB260199C393","doi-asserted-by":"crossref","first-page":"6256","DOI":"10.1021\/pr1004828","article-title":"2D-DiGE analysis of the human endometrial secretome reveals differences between receptive and nonreceptive states in fertile and infertile women","volume":"9","author":"Hannan","year":"2010","journal-title":"J. Proteome Res."},{"key":"2026102020140826100_RSOB260199C394","doi-asserted-by":"crossref","first-page":"113698","DOI":"10.1016\/j.bios.2021.113698","article-title":"Beyond liquid biopsy: toward non-invasive assays for distanced cancer diagnostics in pandemics","volume":"196","author":"Ferrara","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"2026102020140826100_RSOB260199C395","doi-asserted-by":"crossref","first-page":"8507","DOI":"10.1038\/s41467-025-63501-3","article-title":"Advances in biomonitoring technologies for women's health","volume":"16","author":"Moghimikandelousi","year":"2025","journal-title":"Nat. Commun."},{"key":"2026102020140826100_RSOB260199C396","doi-asserted-by":"crossref","first-page":"e45139","DOI":"10.2196\/45139","article-title":"Innovative approaches to menstruation and fertility tracking using wearable reproductive health technology: systematic review","volume":"26","author":"Lyzwinski","year":"2024","journal-title":"J. Med. Internet Res."},{"key":"2026102020140826100_RSOB260199C397","doi-asserted-by":"crossref","first-page":"105281","DOI":"10.1016\/j.rbmo.2025.105281","article-title":"Digital twins in fertility, assisted reproductive technology and preSgnancy: a systematic review","volume":"52","author":"Vall\u00e9e","year":"2026","journal-title":"Reprod. Biomed. Online"},{"key":"2026102020140826100_RSOB260199C398","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.fertnstert.2026.05.165","article-title":"Novel polycystic ovary syndrome clusters identified by endocrine-metabolic clustering: impact on reproductive outcomes after fertility treatment","volume":"126","author":"Ho","year":"2026","journal-title":"Fertil. Steril."},{"key":"2026102020140826100_RSOB260199C399","doi-asserted-by":"crossref","first-page":"1092143","DOI":"10.3389\/fmicb.2023.1092143","article-title":"Gene differential co-expression analysis of male infertility patients based on statistical and machine learning methods","volume":"14","author":"Jia","year":"2023","journal-title":"Front. Microbiol."},{"key":"2026102020140826100_RSOB260199C400","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12888-025-06637-2","article-title":"Using network analysis to identify central symptoms of depression and anxiety in different profiles of infertility patients","volume":"25","author":"Liu","year":"2025","journal-title":"BMC Psychiatry"}],"container-title":["Open Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/rsob\/article-pdf\/doi\/10.1098\/rsob.260199\/6172252\/rsob.260199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rsob\/article-pdf\/doi\/10.1098\/rsob.260199\/6172252\/rsob.260199.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:14:52Z","timestamp":1792541692000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rsob\/article\/16\/10\/260199\/483785\/Cracking-the-fertility-code-a-comprehensive-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":400,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,7]]}},"URL":"https:\/\/doi.org\/10.1098\/rsob.260199","relation":{},"ISSN":["2046-2441"],"issn-type":[{"value":"2046-2441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"article-number":"260199"}}