{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T16:21:25Z","timestamp":1778170885330,"version":"3.51.4"},"reference-count":52,"publisher":"The Royal Society","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"name":"German Federal Ministry of Education","award":["CLIOMMICS (01ZX1609)"],"award-info":[{"award-number":["CLIOMMICS (01ZX1609)"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB\/TRR79, TP B1"],"award-info":[{"award-number":["SFB\/TRR79, TP B1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003801","name":"Heidelberg Graduate School of Mathematical and Computational Methods for the Sciences, University of Heidelberg","doi-asserted-by":"publisher","award":["Stipendiary for Marcel Mohr"],"award-info":[{"award-number":["Stipendiary for Marcel Mohr"]}],"id":[{"id":"10.13039\/501100003801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["R. Soc. open sci."],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Plasma cells (PCs) are the main antibody-producing cells in humans. They are long-lived so that specific antibodies against either pathogens or vaccines are produced for decades. PC longevity is attributed to specific areas within the bone marrow micro-environment, the so-called \u2018niche\u2019, providing the cells with required growth and survival factors. With antigen encounters, e.g. infection or vaccination, new PCs are generated and home to the bone marrow where they compete with resident PCs for the niche. We propose a parametrized mathematical model describing healthy PC dynamics in the bone marrow. The model accounts for competition for the niche between newly produced PCs owing to vaccination and resident PCs. Mathematical analysis and numerical simulations of the model allow explanation of the recovery of PC homoeostasis after a vaccine-induced perturbation, and the fraction of vaccine-specific PCs inside the niche. The model enables quantification of the niche-related dynamics of PCs, i.e. the duration of PC transition into the niche and the impact of different rates for PC transitions into and out of the niche on the observed cell dynamics. Ultimately, it provides a potential basis for further investigations in health and disease.<\/jats:p>","DOI":"10.1098\/rsos.170759","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T11:00:27Z","timestamp":1516791627000},"page":"170759","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Quantification of plasma cell dynamics using mathematical modelling"],"prefix":"10.1098","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6553-8651","authenticated-orcid":false,"given":"Marcel","family":"Mohr","sequence":"first","affiliation":[{"name":"Heidelberg University, Institute of Applied Mathematics, BIOQUANT and IWR, Heidelberg, Germany"},{"name":"Heidelberg University Hospital, Medical Clinic V, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Hose","sequence":"additional","affiliation":[{"name":"Heidelberg University Hospital, Medical Clinic V, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Seckinger","sequence":"additional","affiliation":[{"name":"Heidelberg University Hospital, Medical Clinic V, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Marciniak-Czochra","sequence":"additional","affiliation":[{"name":"Heidelberg University, Institute of Applied Mathematics, BIOQUANT and IWR, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066092"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/40540"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80541-5"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12011"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm917"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3795"},{"key":"e_1_3_6_8_2","doi-asserted-by":"crossref","unstructured":"Fairfax KA Kallies A Nutt SL Tarlinton DM. 2008 Plasma cell development: from B-cell subsets to long-term survival niches. In Seminars in immunology vol.\u00a020 (ed. JF Kearney) pp.\u00a049\u201358. Amsterdam The Netherlands: Elsevier..","DOI":"10.1016\/j.smim.2007.12.002"},{"key":"e_1_3_6_9_2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1182\/blood.V85.2.487.487","article-title":"Differentiation of early plasma cells on bone marrow stromal cells requires interleukin-6 for escaping from apoptosis","volume":"85","author":"Kawano MM","year":"1995","journal-title":"Blood"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4213"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.4.1684"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3109"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-110858"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.6.3655"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00940.x"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2727"},{"key":"e_1_3_6_17_2","first-page":"1","article-title":"The bone marrow: the major source of serum immunoglobulins, but still a neglected site of antibody formation","volume":"46","author":"Benner R","year":"1981","journal-title":"Clin. Exp. Immunol"},{"key":"e_1_3_6_18_2","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1128\/JVI.69.3.1895-1902.1995","article-title":"Bone marrow is a major site of long-term antibody production after acute viral infection","volume":"69","author":"Slifka MK","year":"1995","journal-title":"J. Virol."},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5258.54"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1886"},{"key":"e_1_3_6_21_2","unstructured":"Klein B Seckinger A M\u00f6hler T Hose D. 2011 Molecular pathogenesis of multiple myeloma: chromosomal aberrations changes in gene expression cytokine networks and the bone marrow microenvironment. In Multiple myeloma (eds T M\u00f6hler H Goldschmidt) pp.\u00a039\u201386. Berlin Germany: Springer. (doi:10.1007\/978-3-540-85772-3_3)."},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.6.813"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.03.016"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-235960"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00938.x"},{"key":"e_1_3_6_26_2","unstructured":"Bernasconi NL Traggiai E Lanzavecchia A. 2002 Maintenance of serological memory by polyclonal activation of human memory B cells. Sciences 298 2199\u20132202. (doi:10.1126\/science.1076071)"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2507"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1203"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200204)32:4<923::AID-IMMU923>3.0.CO;2-1"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1094"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(200001)60:1<1::AID-JMV1>3.0.CO;2-H"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(97)00120-4"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199607)49:3<235::AID-JMV13>3.0.CO;2-B"},{"key":"e_1_3_6_34_2","first-page":"4644","article-title":"Measles seroepidemiology and decay rate of vaccine-induced measles IgG titers in Taiwan, 1995\u20131997","volume":"19","author":"Lee MS","year":"2001","journal-title":"Vaccines. (Basel)"},{"key":"e_1_3_6_35_2","first-page":"523","article-title":"Modelling antibody response to measles vaccine and subsequent waning of immunity in a low exposure population","volume":"19","author":"Mossong J","year":"2000","journal-title":"Vaccines. (Basel)"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200101)63:1<1::AID-JMV1000>3.0.CO;2-U"},{"key":"e_1_3_6_37_2","first-page":"4324","article-title":"Modeling the long-term antibody response of a human papillomavirus (HPV) virus-like particle (VLP) type 16 prophylactic vaccine","volume":"25","author":"Fraser C","year":"2007","journal-title":"Vaccines. (Basel)"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00912.x"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002418"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00177"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00078"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.05.001"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1981"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402336"},{"key":"e_1_3_6_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni0211-115"},{"key":"e_1_3_6_46_2","volume-title":"Nonlinear regression","author":"Seber GAF","year":"2003"},{"key":"e_1_3_6_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/comjnl\/7.4.308"},{"key":"e_1_3_6_48_2","volume-title":"Introduction to system sensitivity theory","author":"Frank PM","year":"1978"},{"key":"e_1_3_6_49_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301163"},{"key":"e_1_3_6_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00380.x"},{"key":"e_1_3_6_51_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.1.45"},{"key":"e_1_3_6_52_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061289"},{"key":"e_1_3_6_53_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-184226"}],"container-title":["Royal Society Open Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsos.170759","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rsos.170759","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsos.170759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T04:59:06Z","timestamp":1613883546000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsos.170759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1098\/rsos.170759"],"URL":"https:\/\/doi.org\/10.1098\/rsos.170759","relation":{},"ISSN":["2054-5703"],"issn-type":[{"value":"2054-5703","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2017-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}