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Soc. open sci."],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>\n            In this study, a new network pharmacology approach based on the components absorbed into the blood was used to investigate the pharmacodynamic material basis and the pharmacologic mechanism of the\n            <jats:italic>Fufang-Xialian-Capsule<\/jats:italic>\n            (\n            <jats:italic>FXL<\/jats:italic>\n            ) in treating chronic atrophic gastritis (CAG). Initially, we confirmed the components absorbed into the blood by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Then, the network approach, which was based on the results of components absorbed into the blood, was used to analyse the pharmacodynamic material basis and the pharmacologic mechanism of\n            <jats:italic>FXL<\/jats:italic>\n            on treating CAG. As a result, 22 absorbed components were found in rat plasma. Given the results of the absorption analysis of the components, eight pathways associated with CAG development were found. The targets linked to these pathways are the drug targets of\n            <jats:italic>FXL<\/jats:italic>\n            in CAG treatment. The components associated with these targets are the potential pharmacodynamic material basis and exert synergy in regulating pathways during CAG treatment.\n          <\/jats:p>","DOI":"10.1098\/rsos.171806","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T07:35:38Z","timestamp":1528875338000},"page":"171806","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Exploring the potential pharmacodynamic material basis and pharmacologic mechanism of the\n            <i>Fufang-Xialian-Capsule<\/i>\n            in chronic atrophic gastritis by network pharmacology approach based on the components absorbed into the blood"],"prefix":"10.1098","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1382-0289","authenticated-orcid":false,"given":"Shizhe","family":"Li","sequence":"first","affiliation":[{"name":"National Center of Mass Spectrometry in Changchun and Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry and Chemical Biology Laboratory, Changchun 130022, People's Republic of China"},{"name":"College of Chemistry, Jilin University, Changchun 130012, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Xu","sequence":"additional","affiliation":[{"name":"National Center of Mass Spectrometry in Changchun and Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry and Chemical Biology Laboratory, Changchun 130022, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Liu","sequence":"additional","affiliation":[{"name":"National Center of Mass Spectrometry in Changchun and Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry and Chemical Biology Laboratory, Changchun 130022, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"National Center of Mass Spectrometry in Changchun and Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry and Chemical Biology Laboratory, Changchun 130022, People's Republic of China"},{"name":"State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifeng","family":"Pi","sequence":"additional","affiliation":[{"name":"National Center of Mass Spectrometry in Changchun and Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry and Chemical Biology Laboratory, Changchun 130022, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenrui","family":"Song","sequence":"additional","affiliation":[{"name":"National Center of Mass Spectrometry in Changchun and Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry and Chemical Biology Laboratory, Changchun 130022, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongri","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Chemistry, Jilin University, Changchun 130012, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2018,6,13]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2015.09.013"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep45580"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800668105"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-016-0445-5"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2016.09.044"},{"key":"e_1_3_7_7_2","first-page":"914","article-title":"The application practice of clinically modified Zhang Zhongjing's Banxiaxiexin decoction in treating chronic gastritis","volume":"8","author":"Yun B","year":"2013","journal-title":"World Chin. 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