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Soc. open sci."],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>The utility of characterizing the effects of strain variation and individual\/subgroup susceptibility on dose\u2013response outcomes has motivated the search for new approaches beyond the popular use of the exponential dose\u2013response model for listeriosis. While descriptive models can account for such variation, they have limited power to extrapolate beyond the details of particular outbreaks. By contrast, this study exhibits dose\u2013response relationships from a mechanistic basis, quantifying key biological factors involved in pathogen\u2013host dynamics. An efficient computational algorithm and geometric interpretation of the infection pathway are developed to connect dose\u2013response relationships with the underlying bistable dynamics of the model. Relying on<jats:italic>in vitro<\/jats:italic>experiments as well as outbreak data, we estimate plausible parameters for the human context. Despite the presence of uncertainty in such parameters, sensitivity analysis reveals that the host response is most influenced by the pathogen\u2013immune system interaction. In particular, we show how variation in this interaction across a subgroup of the population dictates the shape of dose\u2013response curves. Finally, in terms of future experimentation, our model results provide guidelines and highlight vital aspects of the interplay between immune cells and particular strains of<jats:italic>Listeria monocytogenes<\/jats:italic>that should be examined.<\/jats:p>","DOI":"10.1098\/rsos.180343","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T07:27:20Z","timestamp":1533108440000},"page":"180343","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Advancing risk assessment: mechanistic dose\u2013response modelling of<i>Listeria monocytogenes<\/i>infection in human populations"],"prefix":"10.1098","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6557-828X","authenticated-orcid":false,"given":"Ashrafur","family":"Rahman","sequence":"first","affiliation":[{"name":"Laboratory for Industrial and Applied Mathematics, Centre for Disease Modelling, Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada M3J 1P3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Munther","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Cleveland State University, Cleveland, OH 44115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamir","family":"Fazil","sequence":"additional","affiliation":[{"name":"National Microbiology Laboratory, Public Health Agency of Canada, Guelph, Ontario, Canada N1G 5B2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Smith","sequence":"additional","affiliation":[{"name":"National Microbiology Laboratory, Public Health Agency of Canada, Guelph, Ontario, Canada N1G 5B2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Wu","sequence":"additional","affiliation":[{"name":"Laboratory for Industrial and Applied Mathematics, Centre for Disease Modelling, Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada M3J 1P3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2018,8]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2011.01.008"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1605(96)01107-5"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.07.043"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112371108"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X.JFP-11-417"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059852"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2003.12.002"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a010009"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05958-11"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01366-06"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02626-10"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-52.10.696"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01514-14"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.3.1574-1579.2003"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00373"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/es504422q"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/risa.12235"},{"key":"e_1_3_6_19_2","unstructured":"FAO\/WHO. 2004 Risk assessment of Listeria monocytogenes in ready-to-eat foods. 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