{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:53:01Z","timestamp":1768722781094,"version":"3.49.0"},"reference-count":41,"publisher":"The Royal Society","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"name":"Austrian Society of Epileptology"},{"name":"Austrian Society of Neurology"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["R. Soc. open sci."],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>Social behaviour of healthy humans and its neural correlates have been extensively studied in social neuroscience and neuroeconomics. Whereas it is well established that several types of epilepsies, such as frontal lobe epilepsy, lead to social cognitive impairments, experimental evidence on how these translate into behavioural symptoms is scarce. Furthermore, it is unclear whether social cognitive or behavioural disturbances have an impact on therapy adherence, which is critical for effective disease management, but generally low in these patients. In order to investigate the relationship between social cognition, social behaviour, and therapy adherence in patients with frontal lobe epilepsies (FLE), we designed a study combining conventional neuropsychological with behavioural economic and functional magnetic resonance imaging (fMRI) methodology. Fifteen patients and 15 healthy controls played a prisoners' dilemma game (an established game to operationalize social behaviour) while undergoing fMRI. Additionally, social cognitive, basic neuropsychological variables, and therapy adherence were assessed. Our results implicate that social behaviour is indeed affected and can be quantified using neuroeconomic methods in patients with FLE. Impaired social behaviour in these patients might be a consequence of altered brain activation in the medial prefrontal cortex and play a role in low therapy adherence. Finally, this study serves as an example of how to integrate neuroeconomic methods in neurology.<\/jats:p>","DOI":"10.1098\/rsos.180850","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T08:47:29Z","timestamp":1566982049000},"page":"180850","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Social cognition, behaviour and therapy adherence in frontal lobe epilepsy: a study combining neuroeconomic and neuropsychological methods"],"prefix":"10.1098","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6285-8104","authenticated-orcid":true,"given":"Andrija","family":"Javor","sequence":"first","affiliation":[{"name":"Department of Neurology 2, Kepler University Clinic, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Ciumas","sequence":"additional","affiliation":[{"name":"Translational and Integrative Group in Epilepsy Research (TIGER), INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, University Lyon 1, Lyon, France"},{"name":"Department of Clinical Neurosciences, CHUV, Lausanne, Switzerland"},{"name":"Epilepsy Institute (IDEE), Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Ibarrola","sequence":"additional","affiliation":[{"name":"CERMEP - Imagerie du vivant, MRI department and CNRS UMS3453, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Ryvlin","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, CHUV, Lausanne, Switzerland"},{"name":"Epilepsy Institute (IDEE), Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Rheims","sequence":"additional","affiliation":[{"name":"Translational and Integrative Group in Epilepsy Research (TIGER), INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, University Lyon 1, Lyon, France"},{"name":"Epilepsy Institute (IDEE), Lyon, France"},{"name":"Department of Functional Neurology and Epileptology, Hospices Civils de Lyon and University of Lyon, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2005.07.018"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/ebeh.2001.0259"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00685.x"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/406755"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00755-9"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165998"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2006.06.003"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.08.027"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905203402008"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.2001.00363.x"},{"key":"e_1_3_6_12_2","volume-title":"Adherence to long-term therapies: evidence for action","author":"Sabat\u00e9 E","year":"2003"},{"issue":"1","key":"e_1_3_6_13_2","first-page":"37","article-title":"Neurobiological links between epilepsy and mood disorders","volume":"16","author":"Salzberg M","year":"2011","journal-title":"Neurol. 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