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Soc. open sci."],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Sophoricoside, which is an isoflavone glycoside found in many plant species, has recently attracted attention because of its anti-fertility activity. One solvent-free form, two solvatomorphs and an amorphous phase of sophoricoside are reported for the first time. X-ray diffractometry, differential scanning calorimetry, thermal gravimetric analysis and Fourier-transform infrared spectroscopy were used to characterize the different forms. The results show that factors such as crystal symmetry, intermolecular arrangement, conformational flexibility, hydrogen-bonding interactions and solvent incorporation lead to different solid-state forms. An investigation of the transformations of the four forms showed that they can interconvert with each other under certain conditions. Amorphous phase and solvatomorphism were unstable but can improve the solubility of sophoricoside in water.<\/jats:p>","DOI":"10.1098\/rsos.181905","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T10:43:08Z","timestamp":1548672188000},"page":"181905","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["New crystal forms and amorphous phase of sophoricoside: X-ray structures and characterization"],"prefix":"10.1098","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0895-7822","authenticated-orcid":true,"given":"Cheng","family":"Xing","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Polymorphic Drugs, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo shun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Polymorphic Drugs, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning bo","family":"Gong","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Polymorphic Drugs, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan","family":"hua Du","sequence":"additional","affiliation":[{"name":"Beijing City Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Lu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Polymorphic Drugs, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2019,1,23]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21274"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-5428(05)32010-7"},{"key":"e_1_3_5_4_2","volume-title":"Polymorphism in pharmaceutical solids","author":"Brittain HG","year":"2009","edition":"2"},{"key":"e_1_3_5_5_2","unstructured":"FDA. 2013 Center for Drug Evaluation and Research. 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