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Soc. open sci."],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>\n            Abnormal fluid dynamics at the ascending aorta may be at the origin of aortic aneurysms. This study was aimed at comparing the performance of computational fluid dynamics (CFD) and fluid\u2013structure interaction (FSI) simulations against four-dimensional (4D) flow magnetic resonance imaging (MRI) data; and to assess the capacity of advanced fluid dynamics markers to stratify aneurysm progression risk. Eight Marfan syndrome (MFS) patients, four with stable and four with dilating aneurysms of the proximal aorta, and four healthy controls were studied. FSI and CFD simulations were performed with MRI-derived geometry, inlet velocity field and Young's modulus. Flow displacement, jet angle and maximum velocity evaluated from FSI and CFD simulations were compared to 4D flow MRI data. A dimensionless parameter, the shear stress ratio (SSR), was evaluated from FSI and CFD simulations and assessed as potential correlate of aneurysm progression. FSI simulations successfully matched MRI data regarding descending to ascending aorta flow rates (\n            <jats:italic>R<\/jats:italic>\n            <jats:sup>2<\/jats:sup>\n            = 0.92) and pulse wave velocity (\n            <jats:italic>R<\/jats:italic>\n            <jats:sup>2<\/jats:sup>\n            = 0.99). Compared to CFD, FSI simulations showed significantly lower percentage errors in ascending and descending aorta in flow displacement (\u221246% ascending, \u221241% descending), jet angle (\u221228% ascending, \u221250% descending) and maximum velocity (\u221237% ascending, \u221234% descending) with respect to 4D flow MRI. FSI- but not CFD-derived SSR differentiated between stable and dilating MFS patients. Fluid dynamic simulations of the thoracic aorta require fluid\u2013solid interaction to properly reproduce complex haemodynamics. FSI- but not CFD-derived SSR could help stratifying MFS patients.\n          <\/jats:p>","DOI":"10.1098\/rsos.191752","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T08:06:12Z","timestamp":1580889972000},"page":"191752","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["Fluid\u2013structure interaction simulations outperform computational fluid dynamics in the description of thoracic aorta haemodynamics and in the differentiation of progressive dilation in Marfan syndrome patients"],"prefix":"10.1098","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0040-928X","authenticated-orcid":true,"given":"R.","family":"Pons","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering and Material Sciences, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, 08017 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Guala","sequence":"additional","affiliation":[{"name":"Hospital Universitari Vall d'Hebron, Department of Cardiology, CIBER-CV, Vall d'Hebron Institut de recerca (VHIR), Universitat Autonoma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Rodr\u00edguez-Palomares","sequence":"additional","affiliation":[{"name":"Hospital Universitari Vall d'Hebron, Department of Cardiology, CIBER-CV, Vall d'Hebron Institut de recerca (VHIR), Universitat Autonoma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Cajas","sequence":"additional","affiliation":[{"name":"Barcelona Supercomputing Center (BSC-CNS), Department of Computer Applications in Science and Engineering, C\/Jordi Girona 29, 08034 Barcelona, Spain"},{"name":"Escuela Nacional de Estudios Superiors, Unidad M\u00e9rida, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Carretera M\u00e9rida-Tetiz, Km 4, Uc\u00fa, Yucat\u00e1n, 97357, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8736-2095","authenticated-orcid":true,"given":"L.","family":"Dux-Santoy","sequence":"additional","affiliation":[{"name":"Hospital Universitari Vall d'Hebron, Department of Cardiology, CIBER-CV, Vall d'Hebron Institut de recerca (VHIR), Universitat Autonoma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Teixid\u00f3-Tura","sequence":"additional","affiliation":[{"name":"Hospital Universitari Vall d'Hebron, Department of Cardiology, CIBER-CV, Vall d'Hebron Institut de recerca (VHIR), Universitat Autonoma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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