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Soc. open sci."],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>The structural characteristic of oxidized poly (2-hydroxyethyl acrylate) (OP) was confirmed by high-performance liquid chromatography, gel permeation chromatography and hydroxylamine hydrochloride titration. The results demonstrated that OP prepared through 2,2,6,6-tetramethylpiperidine-1-oxyl-mediated oxidation of poly (2-hydroxyethyl acrylate) was featured by multiple aldehyde groups on its side chain, with no free formaldehyde produced during the oxidation process. The computational simulation for the electrophilic reactivity of OP molecule showed that the reactivity of the aldehyde groups in OP with the amino groups of collagen was comparable to that of glutaraldehyde. In this study, OP was chosen as a collagen modifier to investigate the modification effects on the secondary structure, aggregation behaviour and thermal stability of collagen. The covalent cross-linking occurred between the aldehyde groups of OP and the amino groups of collagen under alkaline condition. The covalent binding between OP and collagen was strengthened with the increasing reaction pH and OP dosage, and the triple helix of collagen was altered to some degree. Furthermore, OP promoted the intense aggregation of collagen and enhanced the thermal stability of collagen. This work provides guidance for preparing novel collagen modifier with multiple aldehyde groups.<\/jats:p>","DOI":"10.1098\/rsos.201892","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T13:28:16Z","timestamp":1613568496000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Structure validation of oxidized poly (2-hydroxyethyl acrylate) with multiple aldehyde groups and its application for collagen modification"],"prefix":"10.1098","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8211-8165","authenticated-orcid":true,"given":"Baohua","family":"Liu","sequence":"first","affiliation":[{"name":"College of Food and Biological Engineering, Sichuan Key Laboratory of Meat Processing, Chengdu University, Chengdu, Sichuan 610106, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food and Biological Engineering, Sichuan Key Laboratory of Meat Processing, Chengdu University, Chengdu, Sichuan 610106, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Ji","sequence":"additional","affiliation":[{"name":"College of Food and Biological Engineering, Sichuan Key Laboratory of Meat Processing, Chengdu University, Chengdu, Sichuan 610106, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Bai","sequence":"additional","affiliation":[{"name":"College of Food and Biological Engineering, Sichuan Key Laboratory of Meat Processing, Chengdu University, Chengdu, Sichuan 610106, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food and Biological Engineering, Sichuan Key Laboratory of Meat Processing, Chengdu University, Chengdu, Sichuan 610106, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayu","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food and Biological Engineering, Sichuan Key Laboratory of Meat Processing, Chengdu University, Chengdu, Sichuan 610106, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00396-004-1115-2"},{"key":"e_1_3_6_3_2","first-page":"182","article-title":"Bioactive scaffolds mimicking natural dentin structure","volume":"90","author":"Vall\u00e9s Lluch A","year":"2010","unstructured":"Vall\u00e9s Lluch A, Campillo Fern\u00e1ndez A, Gallego Ferrer G, Monle\u00f3n Pradas M. 2010 Bioactive scaffolds mimicking natural dentin structure. 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