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Soc. open sci."],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>\n            A quarter of the world's population experience wheezing. These sounds have been used for diagnosis since the time of the Ebers Papyrus (\n            <jats:italic>ca<\/jats:italic>\n            1500 BC). We know that wheezing is a result of the oscillations of the airways that make up the lung. However, the physical mechanisms for the onset of wheezing remain poorly understood, and we do not have a quantitative model to predict when wheezing occurs. We address these issues in this paper. We model the airways of the lungs by a modified Starling resistor in which airflow is driven through thin, stretched elastic tubes. By completing systematic experiments, we find a generalized \u2018tube law\u2019 that describes how the cross-sectional area of the tubes change in response to the transmural pressure difference across them. We find the necessary conditions for the onset of oscillations that represent wheezing and propose a flutter-like instability model for it about a heavily deformed state of the tube. Our findings allow for a predictive tool for wheezing in lungs, which could lead to better diagnosis and treatment of lung diseases.\n          <\/jats:p>","DOI":"10.1098\/rsos.201951","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T08:07:30Z","timestamp":1614154050000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["An experimental investigation to model wheezing in lungs"],"prefix":"10.1098","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0667-5861","authenticated-orcid":true,"given":"A. 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