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Soc. open sci."],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>Despite being one of the first countries to implement mass drug administration (MDA) for elimination of lymphatic filariasis (LF) in 2001 after a pilot study in 2000, the Philippines is yet to eliminate the disease as a public health problem with 6 out of the 46 endemic provinces still implementing MDA for LF as of 2018. In this work, we propose a mathematical model of the transmission dynamics of LF in the Philippines and a control strategy for its elimination using MDA. Sensitivity analysis using the Latin hypercube sampling and partial rank correlation coefficient methods suggests that the infected human population is most sensitive to the treatment parameters. Using the available LF data in Caraga Region from the Philippine Department of Health, we estimate the treatment rates<jats:italic>r<\/jats:italic><jats:sub>1<\/jats:sub>and<jats:italic>r<\/jats:italic><jats:sub>2<\/jats:sub>using the least-squares parameter estimation technique. Parameter bootstrapping showed small variability in the parameter estimates. Finally, we apply optimal control theory with the objective of minimizing the infected human population and the corresponding implementation cost of MDA, using the treatment coverage<jats:italic>\u03b3<\/jats:italic>as the control parameter. Simulation results highlight the importance of maintaining a high MDA coverage per year to effectively minimize the infected population by the year 2030.<\/jats:p>","DOI":"10.1098\/rsos.201965","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T07:09:42Z","timestamp":1625036982000},"page":"201965","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["A mathematical model of the dynamics of lymphatic filariasis in Caraga Region, the Philippines"],"prefix":"10.1098","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5522-1658","authenticated-orcid":true,"given":"Pamela Kim N.","family":"Salonga","sequence":"first","affiliation":[{"name":"Institute of Mathematics, University of the Philippines Diliman, Quezon City, Philippines"},{"name":"Natural Sciences Research Institute, University of the Philippines Diliman, Quezon City, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0953-9822","authenticated-orcid":true,"given":"Victoria May P.","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Institute of Mathematics, University of the Philippines Diliman, Quezon City, Philippines"},{"name":"Natural Sciences Research Institute, University of the Philippines Diliman, Quezon City, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3507-0327","authenticated-orcid":true,"given":"Renier G.","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Institute of Mathematics, University of the Philippines Diliman, Quezon City, Philippines"},{"name":"Natural Sciences Research Institute, University of the Philippines Diliman, Quezon City, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Vicente Y.","family":"Belizario","sequence":"additional","affiliation":[{"name":"College of Public Health and Neglected Tropical Diseases Study Group, National Institutes of Health, University of the Philippines Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2019.105284"},{"key":"e_1_3_6_3_2","unstructured":"World Health Organization. 2017 Integrating neglected tropical diseases into global health and development: fourth WHO report on neglected tropical diseases."},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-020-0630-9"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(11)60150-8"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.031047"},{"key":"e_1_3_6_7_2","unstructured":"World Health Organization Global Programme to Eliminate Lymphatic Filariasis. 2005 Monitoring and epidemiological assessment of the programme to eliminate lymphatic filariasis at implementation unit level. 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