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Soc. open sci."],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Research on the second plague pandemic that swept over Europe from the fourteenth to nineteenth centuries mainly relies on the exegesis of contemporary texts and is prone to interpretive bias. By leveraging certain bioinformatic tools routinely used in biology, we developed a quantitative lexicography of 32 texts describing two major plague outbreaks, using contemporary plague-unrelated texts as negative controls. Nested, network and category analyses of a 207-word pan-lexicome, comprising overrepresented terms in plague-related texts, indicated that \u2018buboes' and \u2018carbuncles' are words that were significantly associated with the plague and signalled an ectoparasite-borne plague. Moreover, plague-related words were associated with the terms \u2018merchandise\u2019, \u2018movable\u2019, \u2018tatters', \u2018bed\u2019 and \u2018clothes'. Analysing ancient texts using the method reported in this paper can certify plague-related historical records and indicate the particularities of each plague outbreak, which can inform on the potential sources for the causative\n                    <jats:italic>Yersinia pestis<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1098\/rsos.210039","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T03:05:43Z","timestamp":1641351943000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Differential word expression analyses highlight plague dynamics during the second pandemic"],"prefix":"10.1098","volume":"9","author":[{"given":"R\u00e9mi","family":"Barbieri","sequence":"first","affiliation":[{"name":"Aix Marseille Univ., IRD, MEPHI, IHU M\u00e9diterran\u00e9e Infection, Marseille 13005, France"},{"name":"UMR 7268, Anthropologie bioculturelle, Droit, Ethique et Sant\u00e9, Aix Marseille Univ, 11 CNRS, EFS, ADES, Marseille 13344, France"},{"name":"IHU M\u00e9diterran\u00e9e Infection, Marseille 13005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Nodari","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Pediatric Clinical Research Center \u2018Romeo and Enrica Invernizzi\u2019, University of Milan, Milan 20133, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Signoli","sequence":"additional","affiliation":[{"name":"UMR 7268, Anthropologie bioculturelle, Droit, Ethique et Sant\u00e9, Aix Marseille Univ, 11 CNRS, EFS, ADES, Marseille 13344, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Epis","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Pediatric Clinical Research Center \u2018Romeo and Enrica Invernizzi\u2019, University of Milan, Milan 20133, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ., IRD, MEPHI, IHU M\u00e9diterran\u00e9e Infection, Marseille 13005, France"},{"name":"IHU M\u00e9diterran\u00e9e Infection, Marseille 13005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0768-1139","authenticated-orcid":true,"given":"Michel","family":"Drancourt","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ., IRD, MEPHI, IHU M\u00e9diterran\u00e9e Infection, Marseille 13005, France"},{"name":"IHU M\u00e9diterran\u00e9e Infection, Marseille 13005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.1.35"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00044-19"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2009677117"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.21.12637"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26594-0"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105107108"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10549"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12994"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12154-0"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4181(96)00017-6"},{"key":"e_1_3_6_12_2","volume-title":"The Black Death, 1346-1353: the complete history","author":"Benedictow OJ","year":"2004","unstructured":"Benedictow OJ. 2004 The Black Death, 1346-1353: the complete history. 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