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Soc. open sci."],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n                    The respiratory system is the primary route of infection for many contagious pathogens. Mucociliary clearance of inhaled pathogens is an important innate defence mechanism sustained by the rhythmic movement of epithelial cilia. To counter host defences, viral pathogens target epithelial cells and cilia. For instance, the avian influenza virus that targets ciliated cells modulates the expression of\n                    <jats:italic>WDR93<\/jats:italic>\n                    , a central ciliary apparatus C1d projection component. Lineage-specific prevalence of such host defence genes results in differential susceptibility. In this study, the comparative analysis of approximately 500 vertebrate genomes from seven taxonomic classes spanning 73 orders confirms the widespread conservation of\n                    <jats:italic>WDR93<\/jats:italic>\n                    across these different vertebrate groups. However, we established loss of the\n                    <jats:italic>WDR93<\/jats:italic>\n                    in landfowl, geese and other phylogenetically independent bird species due to gene-disrupting changes. The lack of\n                    <jats:italic>WDR93<\/jats:italic>\n                    transcripts in species with gene loss in contrast to its expression in species with an intact gene confirms gene loss. Notably, species with\n                    <jats:italic>WDR93<\/jats:italic>\n                    loss have concurrently lost another C1d component,\n                    <jats:italic>CFAP46<\/jats:italic>\n                    , through large segmental deletions. Understanding the consequences of such gene loss may provide insight into their role in host\u2013pathogen interactions and benefit global pathogen surveillance efforts by prioritizing species missing host defence genes and identifying putative zoonotic reservoirs.\n                  <\/jats:p>","DOI":"10.1098\/rsos.230801","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T03:05:34Z","timestamp":1692759934000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Concurrent loss of ciliary genes\n                    <i>WDR93<\/i>\n                    and\n                    <i>CFAP46<\/i>\n                    in phylogenetically distant birds"],"prefix":"10.1098","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8994-7079","authenticated-orcid":false,"given":"Buddhabhushan Girish","family":"Salve","sequence":"first","affiliation":[{"name":"Computational Evolutionary Genomics Lab, Department of Biological Sciences, IISER Bhopal, Bhauri, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amia Miriam","family":"Kurian","sequence":"additional","affiliation":[{"name":"Computational Evolutionary Genomics Lab, Department of Biological Sciences, IISER Bhopal, Bhauri, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8703-6991","authenticated-orcid":false,"given":"Nagarjun","family":"Vijay","sequence":"additional","affiliation":[{"name":"Computational Evolutionary Genomics Lab, Department of Biological Sciences, IISER Bhopal, Bhauri, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00014-10"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0412"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2011-0011RT"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2021.787128"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.05.009"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00191.2022"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807547200"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2018.08.004"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000136349"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.749077"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-019-0704-5"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.581340"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00283.2020"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.69.040705.141236"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2023.01.013"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.05.014"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308001101"},{"key":"e_1_3_8_19_2","first-page":"1","article-title":"Sialic acid receptors of viruses","volume":"367","author":"Matrosovich M","year":"2015","unstructured":"Matrosovich M, Herrler G, Klenk HD. 2015 Sialic acid receptors of viruses. 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