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Open Sci."],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n                    Long-lasting exposure to low gravity, such as in lunar settlements planned by the ongoing Artemis Program, elicits muscle hypotrophy, bone demineralization, cardio-respiratory and neuro-control deconditioning, against which optimal countermeasures are still to be designed. Rather than training selected muscle groups only, \u2018whole-body\u2019 activities such as locomotion seem better candidates, but at Moon gravity both \u2018pendular\u2019 walking and bouncing gaits like running exhibit abnormal dynamics at faster speeds. We theoretically and experimentally show that much greater self-generated artificial gravities can be experienced on the Moon by running horizontally inside a static 4.7 m radius cylinder (motorcyclists\u2019 \u2018Wall of Death\u2019 of amusement parks) at speeds preventing downward skidding. To emulate lunar gravity, 83% of body weight was unloaded by pre-tensed (36 m) bungee jumping bands. Participants unprecedentedly maintained horizontal fast running (5.4\u20136.5 m\u2009s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) for a few circular laps, with intense metabolism (estimated as 54\u201374 mlO\n                    <jats:sub>2<\/jats:sub>\n                    \u2009kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u2009min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and peak forces during foot contact, inferred by motion analysis, of 2\u20133 Earth body weight (corresponding to terrestrial running at 3\u20134 m\u2009s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), high enough to prevent bone calcium resorption. A training regime of a few laps a day promises to be a viable countermeasure for astronauts to quickly combat whole-body deconditioning, for further missions and home return.\n                  <\/jats:p>","DOI":"10.1098\/rsos.231906","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T07:17:01Z","timestamp":1714547821000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Horizontal running inside circular walls of Moon settlements: a comprehensive countermeasure for low-gravity deconditioning?"],"prefix":"10.1098","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0120-4406","authenticated-orcid":true,"given":"Alberto E.","family":"Minetti","sequence":"first","affiliation":[{"name":"Locomotion Physiomechanics Laboratory, Department of Pathophysiology and Transplantation, University of Milan , Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Luciano","sequence":"additional","affiliation":[{"name":"Locomotion Physiomechanics Laboratory, Department of Pathophysiology and Transplantation, University of Milan , Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Natalucci","sequence":"additional","affiliation":[{"name":"Locomotion Physiomechanics Laboratory, Department of Pathophysiology and Transplantation, University of Milan , Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0109-4964","authenticated-orcid":true,"given":"Gaspare","family":"Pavei","sequence":"additional","affiliation":[{"name":"Locomotion Physiomechanics Laboratory, Department of Pathophysiology and Transplantation, University of Milan , Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2024,5]]},"reference":[{"key":"e_1_3_8_2_2","unstructured":"National Aeronautics and Space Administration (NASA) . 2020 NASA\u2019s lunar exploration program overview. 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