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Soc. Open Sci."],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>\n            Ruthenium(II) complexes (\n            <jats:bold>Ru1<\/jats:bold>\n            \u2013\n            <jats:bold>Ru3<\/jats:bold>\n            ) with the general formula [Ru(O-O)(PPh\n            <jats:sub>3<\/jats:sub>\n            )\n            <jats:sub>2<\/jats:sub>\n            (bipy)]PF\n            <jats:sub>6,<\/jats:sub>\n            bearing two triphenylphosphine (PPh\n            <jats:sub>3<\/jats:sub>\n            ), bipyridine (bipy) and a series of natural and synthetic \u03b2-diketones (O,O) ligands were synthesized and characterized using various analytical techniques. The interaction between the complexes and\n            <jats:italic>calf thymus<\/jats:italic>\n            DNA (CT-DNA) was investigated and demonstrated a weak interaction. The cytotoxicity of the complexes was investigated against breast cancer cells (MDA-MB-231 and MCF-7), lung cancer cells (A549), cisplatin-resistant ovarian cancer cells (A2780\n            <jats:italic>cis<\/jats:italic>\n            ), as well as non-tumour lung (MRC-5) and non-tumour breast (MCF-10A) cell lines. All complexes exhibited cytotoxic activity against all the cell lines studied, with half maximal inhibitory concentration (IC\n            <jats:sub>50<\/jats:sub>\n            ) values ranging from 0.39 to 13 \u00b5M. Notably, the three complexes demonstrated selectivity against the A2780\n            <jats:italic>cis<\/jats:italic>\n            cell line, with IC\n            <jats:sub>50<\/jats:sub>\n            ranging from 0.39 to 0.82 \u00b5M. Among them, Ru2 exhibited the highest cytotoxicity, with an IC\n            <jats:sub>50<\/jats:sub>\n            value of 0.39 \u00b5M. Consequently, this new class of complexes shows good selectivity towards cisplatin-resistant ovarian cancer cells and it is promising for further investigation as anti-cancer agents.\n          <\/jats:p>","DOI":"10.1098\/rsos.240353","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T07:22:09Z","timestamp":1722410529000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Ruthenium(II) complexes of curcumin and \u03b2-diketone derivatives: effect of structural modifications on their cytotoxicity"],"prefix":"10.1098","volume":"11","author":[{"given":"Fl\u00e1via E.","family":"Jacinto","sequence":"first","affiliation":[{"name":"Department of Chemistry, Institute of Biological and Exact Sciences, Campus Morro do Cruzeiro, Federal University of Ouro Preto (UFOP), Ouro Preto, MG 35400-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Pires","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Federal University of S\u00e3o Carlos (UFSCar), CP 676, S\u00e3o Carlos, SP 13561-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alzir A.","family":"Batista","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Federal University of S\u00e3o Carlos (UFSCar), CP 676, S\u00e3o Carlos, SP 13561-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia M.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Institute of Biological and Exact Sciences, Campus Morro do Cruzeiro, Federal University of Ouro Preto (UFOP), Ouro Preto, MG 35400-000, Brazil"},{"name":"Institute of Chemistry, University of Bras\u00edlia (UnB) \u2013 Campus Darcy Ribeiro, Bras\u00edlia, DF 70910-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2783-0816","authenticated-orcid":true,"given":"Rodrigo S.","family":"Correa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Institute of Biological and Exact Sciences, Campus Morro do Cruzeiro, Federal University of Ouro Preto (UFOP), Ouro Preto, MG 35400-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-008-9661-9"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2167"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/205698a0"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1691"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr980420v"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00343H"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119512"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2MD00304J"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00088B"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4MT00069B"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA07681K"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.02.039"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.12.028"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/186864"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X13500055"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-21-08370.2001"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.03.036"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/878134"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.03.051"},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.11.028"},{"key":"e_1_3_8_22_2","first-page":"1131","article-title":"Synergism from sequenced combinations of curcumin and epigallocatechin-3- gallate with cisplatin in the killing of human ovarian cancer cells","volume":"31","author":"Yunos NM","year":"2011","unstructured":"Yunos NM, Beale P, Yu JQ, Huq F. 2011 Synergism from sequenced combinations of curcumin and epigallocatechin-3- gallate with cisplatin in the killing of human ovarian cancer cells. 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