{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:55:20Z","timestamp":1792547720773,"version":"4.5.0"},"reference-count":69,"publisher":"The Royal Society","issue":"10","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study investigated the recovery and nanoliposomal formulation of anthocyanin-rich extracts from black rice using choline chloride-based deep eutectic solvents (DESs). Choline chloride\/1,2-propanediol (DES2) produced the highest anthocyanin content, 85.5 \u00b1 3.4 mg l\u22121, after optimization, compared with 25.7 \u00b1 2.1 mg l\u22121 obtained by conventional ethanol extraction. High-resolution QTOF-MS\/MS enabled the tentative assignment of cyanidin 3-O-hexoside-type and peonidin 3-O-hexoside-type compounds based on accurate precursor masses and characteristic product ions; authentic-standard confirmation was not performed. The DES2 extract showed greater apparent thermal stability than the control extract, with estimated half-lives of 30.0 and 16.0 days, respectively, at 45\u00b0C. Anti-oxidant activity was observed in DPPH and ABTS assays, with IC50 values of 0.19 \u00b1 0.06 and 0.16 \u00b1 0.08 mg ml\u22121, respectively. Preliminary antibacterial activity against Escherichia coli was detected under the tested agar-diffusion conditions, whereas activity against Staphylococcus aureus was limited. Nanoliposomal encapsulation achieved an encapsulation efficiency of 73.8 \u00b1 4.3%, a Z-average diameter of 201.3 nm and 89.83 \u00b1 0.65% anthocyanin retention after 28 days at 4\u00b0C. The formulation produced a larger inhibition zone against E. coli than the free extract under the assay conditions. These findings support further investigation, although release kinetics, pharmaceutical efficacy and complete-process sustainability remain unestablished.<\/jats:p>","DOI":"10.1098\/rsos.260927","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:17:24Z","timestamp":1791937044000},"source":"Crossref","is-referenced-by-count":1,"title":["Choline chloride-based deep eutectic solvents for efficient anthocyanin recovery from black rice: process, kinetics and nanoliposomal formulation"],"prefix":"10.1098","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0644-1002","authenticated-orcid":false,"given":"Quang-Hieu","family":"Tran","sequence":"first","affiliation":[{"name":"Faculty of Chemical Engineering, Industrial University of Ho Chi Minh City 1 , Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ba Thanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City 2 , Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dat Pham","family":"Quoc","sequence":"additional","affiliation":[{"name":"Faculty of Food Technology, Saigon Technology University 3 , Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Quynh","family":"Dao","sequence":"additional","affiliation":[{"name":"Faculty of Food Technology, Saigon Technology University 3 , Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi Ngoc","family":"Tram","sequence":"additional","affiliation":[{"name":"Faculty of Food Technology, Saigon Technology University 3 , Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thanh","family":"Danh","sequence":"additional","affiliation":[{"name":"Institute of Advanced Technology, Vietnam Academy of Science and Technology 4 , Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Quoc","family":"Thang","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Engineering, Industrial University of Ho Chi Minh City 1 , Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Van Tan","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Engineering, Industrial University of Ho Chi Minh City 1 , Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"2026102010182057700_RSOS260927C1","doi-asserted-by":"crossref","first-page":"1705983","DOI":"10.3389\/fnut.2025.1705983","article-title":"Black rice as the emerging functional food: bioactive compounds, therapeutic potential and industrial applications","volume":"12","author":"Javed","year":"2025","journal-title":"Front. 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