{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:13:21Z","timestamp":1791191601346,"version":"4.1.0"},"reference-count":37,"publisher":"The Royal Society","issue":"1164","license":[{"start":{"date-parts":[[1979,12,31]],"date-time":"1979-12-31T00:00:00Z","timestamp":315446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1979,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The name Leishmania peruviana was given by Velez (1913) to the parasite responsible for a form of cutaneous leishmaniasis known as \u2018uta\u2019; this disease occurs in the Peruvian Andes. Clinical similarities between uta and \u2018oriental sore\u2019, which is caused by Leishmania tropica of the Eastern Hemisphere, have, however, led to the suggestion that uta is simply due to L. tropica, which was introduced into Latin America by African slaves or European immigrants. Leishmania species are divisible into three distinct sections, according to their pattern of development in their natural (phlebotomine) vectors. One of these sections, the Peripylaria , contains the subspecies of Leishmania braziliensis, and is characterized by parasites that undergo a phase of development attached to the wall of the hindgut (pylorus and ileum), in addition to multiplication in the midgut and subsequent invasion of the foregut. Such development is un\u00adknown in any other group of leishmaniae, including those groups of the section Suprapylaria, which includes parasites of the L. tropica complex. Three isolates of L. peruviana were studied in laboratory-bred sandflies Lutzomyia longipalpis (Lutz &amp; Neiva), and all showed consistent and prolific development of rounded or stumpy flagellates attached to the wall of the hindgut and, in some instances, growth of free, elongate promastigotes throughout the midgut. Development of both L. tropica and L. major, in the same insect, was restricted to massive development of free flagellates in the midgut, up to the cardial valve. From the behaviour of L. peruviana in the sandfly, its slow growth in hamster skin and the small size of its amastigotes, it is concluded that this parsite is (a) dis\u00adtinctly different from both L. tropica and L. major, and (b) closely related to subspecies of L. braziliensis within the section Peripylaria. On this evidence it is also concluded that L. peruviana is indigenous to the American continent. The specific name is best retained for the time being (rather than L. braziliensis peruviana).<\/jats:p>","DOI":"10.1098\/rspb.1979.0107","type":"journal-article","created":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T18:11:28Z","timestamp":1166465488000},"page":"307-318","source":"Crossref","is-referenced-by-count":16,"title":["<i>Leishmania<\/i>\n                    in phlebotomid sandflies. VII. On the taxonomic status of\n                    <i>Leishmania peruviana<\/i>\n                    , causative agent of Peruvian \u2018uta\u2019, as indicated by its development in the sandfly,\n                    <i>Lutzomyia longipalpis<\/i>"],"prefix":"10.1098","volume":"206","author":[{"given":"Ralph","family":"Lainson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. D.","family":"Ready","sequence":"additional","affiliation":[{"name":"Instituto Evandro Chagas da Funda\u00e7\u00e3o Servi\u00e7os de Sa\u03cdde P\u03cdblica, C. P. 3, Bel\u00e9m, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith J.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Instituto Evandro Chagas da Funda\u00e7\u00e3o Servi\u00e7os de Sa\u03cdde P\u03cdblica, C. P. 3, Bel\u00e9m, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","reference":[{"key":"p_1","doi-asserted-by":"crossref","unstructured":"Adler S. 1964 New York: Academic Press. Leishmama.In Advances in parasitology (ed. B. Dawes) vol. 2 pp. 35-96.","DOI":"10.1016\/S0065-308X(08)60586-2"},{"key":"p_2","first-page":"1","article-title":"The evolution of parasitic protozoa","volume":"3","author":"Baker J. R.","year":"1965","journal-title":"Symp. Br. Soc. Parasit."},{"key":"p_3","unstructured":"Borovsky P. F. 1898 Voenno-med. Zh. S Peterb. part 195 no. 11 (76th year) p. 925."},{"key":"p_4","unstructured":"Herrer A. 1951a Estudios sobre leishmaniasis tegumentaria en el Peril. IV. 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London: Academic Press."},{"key":"p_23","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(73)90143-0"},{"key":"p_24","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(76)90202-9"},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1977.0141"},{"key":"p_26","unstructured":"Matta A. 1918 Notas para a historia das leishmanioses da pelle e das mucosas. Amazonas med. 1 11-17."},{"key":"p_27","first-page":"147","article-title":"Existencia de la leishmaniosis cutanea en el perro en la Republica Argentina. Bol. Inst. Clin, quir","volume":"2","author":"Mazza S.","year":"1926","journal-title":"B. Aires"},{"key":"p_28","first-page":"209","article-title":"6 Leishmaniosis tegumentaria y visceral. Bol. Inst. Clin, quir","volume":"2","author":"Mazza S.","year":"1926","journal-title":"B. Aires"},{"key":"p_29","first-page":"310","article-title":"c Consideraciones sobre flebbtomus encontrados en Tabacal y el papel de eStos dipteros en la transmission de las leishmaniosis. Bol","volume":"2","author":"Mazza S.","year":"1926","journal-title":"B. Aires"},{"key":"p_30","first-page":"462","article-title":"Leishmaniose cutdnea en el caballo y neuva observacion de la misma en el perro. Bol","volume":"3","author":"Mazza S.","year":"1927","journal-title":"B. Aires"},{"key":"p_31","first-page":"283","article-title":"Leishmaniasis tegumentaria en perros de Tucumdn. II. Foco domestico de leishmaniasis. An. Inst. Med. reg","volume":"2","author":"Romana C.","year":"1949","journal-title":"Tucumdn"},{"key":"p_32","first-page":"293","article-title":"6 Distribucion de flebdtomos y leishmaniasis en la Argentina. An. Inst. Med. reg","volume":"2","author":"Romana C.","year":"1949","journal-title":"Tucumdn"},{"key":"p_33","doi-asserted-by":"publisher","DOI":"10.2307\/3271021"},{"key":"p_34","first-page":"545","article-title":"Uta et espundia","volume":"6","author":"Velez L. R.","year":"1913","journal-title":"Bull. Soc. Path. exot."},{"key":"p_35","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761972000100002"},{"key":"p_36","unstructured":"Ward R. D. 1974 Studies on the adult and immature stages of some phlebotomid sandflies (Diptera: Phlebotomidae) in northern Brazil. Ph.D. thesis (submitted) Faculty of Science University of London pp. 1-326."},{"key":"p_37","first-page":"269","article-title":"Some methods for membrane feeding of laboratory reared, neotropical sandflies (Diptera: Psychodidae). Ann. trop","volume":"72","author":"Ward R. D.","year":"1978","journal-title":"Med."}],"container-title":["Proceedings of the Royal Society of London. Series B. 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