{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T04:13:16Z","timestamp":1767499996815,"version":"3.48.0"},"reference-count":12,"publisher":"The Royal Society","issue":"1184","license":[{"start":{"date-parts":[[1981,3,11]],"date-time":"1981-03-11T00:00:00Z","timestamp":353116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,3,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Millipore 'discs' impregnated with methylcholanthrene dissolved in wax or in crystalline form implanted subcutaneously in mice evoke an early intense macrophage and giant cell reaction; later the discs become covered with connective tissue, and eventually fibrosarcomas develop in their vicinity. Studies with tritium-labelled material show that under these conditions methylcholanthrene (MC) is removed from the discs and broken down rapidly (half life about 7 days) to a water-soluble product, which diffuses locally, is distributed widely via the blood stream, and is excreted in faeces and urine. Removal of label is halted by whole-body irradiation (550 R) with the disc area shielded; this observation, in conjunction with the histological and autoradiographic findings and the paucity of label in cells stripped from excised discs, points to the conclusion that the removal of MC from impregnated discs, and its subsequent degradation, depend on the presence of macrophages and the continual replacement of spent macrophages by new cells generated centrally. The rate of disappearance of label from implanted [3H]MC discs was not altered by administration of Corynebacterium parvum; this, however, does not exclude the possibility that the metabolic pathways involved in the removal of MC are altered. To investigate this it is proposed to study, in both normal mice and mice treated with C. parvum, the extent to which cytochrome P450 and other enzymes concerned in the activation and detoxification of polycyclic hydrocarbons by liver microsomal fractions are inducible in the macrophages that accumulate in inflammatory exudates. The histological techniques used should be readily applicable to the study of the early stages of chemical carcinogenesis and the host reaction to transformed cells.<\/jats:p>","DOI":"10.1098\/rspb.1981.0006","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T17:06:33Z","timestamp":1166202393000},"page":"269-286","source":"Crossref","is-referenced-by-count":1,"title":["Cellular basis for the loss of carcinogen from methylcholanthrene-impregnated Millipore membrane"],"prefix":"10.1098","volume":"211","author":[{"given":"Michael Francis Addison","family":"Woodruff","sequence":"first","affiliation":[{"name":"M. R. C. Clinical and Population Cytogenetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bard","sequence":"additional","affiliation":[{"name":"M. R. C. Clinical and Population Cytogenetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allyson","family":"Ross","sequence":"additional","affiliation":[{"name":"M. R. C. Clinical and Population Cytogenetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle","family":"Forbes","sequence":"additional","affiliation":[{"name":"M. R. C. Clinical and Population Cytogenetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","reference":[{"key":"p_1","first-page":"493","article-title":"Effect of host immunity on the antigenic strength of primary tumours. J .natn","volume":"49","author":"Bartlett G. L.","year":"1972","journal-title":"Cancer Inst."},{"key":"p_2","unstructured":"Bloom W. & Fawcett D. W. 1975 A textbook of histology (10th edn). Philadelphia: W. B. Saunders."},{"key":"p_3","first-page":"1","article-title":"Chemical carcinogenesis. med","volume":"36","author":"Brooks P.","year":"1980","journal-title":"Bull."},{"key":"p_4","unstructured":"Gelboin H. V. & Ts'o P. O. P. (eds) 1978 Polycyclic hydrocarbons and cancer vol. 1. New York: Academic Press."},{"key":"p_5","doi-asserted-by":"crossref","unstructured":"Mosedale B. & Smith M. A. 1975 Corynebacterium parvum and anaesthetics. Lancet (i) 168.","DOI":"10.1016\/S0140-6736(75)91471-3"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1970.0023"},{"key":"p_7","first-page":"11","article-title":"The metabolic activation of chemical carcinogens. Br. med","volume":"36","author":"Sims P.","year":"1980","journal-title":"Bull."},{"key":"p_8","first-page":"4425","article-title":"Decreased liver and Iung drugmetabolizing activity in mice treated with Corynebacterium parvum","volume":"36","author":"Soyka L. F.","year":"1976","journal-title":"Cancer Res."},{"key":"p_9","doi-asserted-by":"crossref","unstructured":"Takahashi G. 1978 Distribution and excretion of the hydrocarbon 3-methylcholanthrene in the animal body. In Polycyclic hydrocarbons and cancer (ed. H. Y. Gelboin & P. O. P. Ts'o) pp. 233-246. New York: Adademic Press.","DOI":"10.1016\/B978-0-12-279201-4.50018-9"},{"key":"p_10","first-page":"415","article-title":"The origin and kinetics of mononuclear phagocytes. J. exp","volume":"128","author":"Van Furth R.","year":"1968","journal-title":"Med."},{"key":"p_11","unstructured":"Vernon-Roberts B. 1972 The macrophage pp. 52-57. Cambridge University Press."},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1978.0041"}],"container-title":["Proceedings of the Royal Society of London. Series B. 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