{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:01:02Z","timestamp":1784048462211,"version":"3.55.0"},"reference-count":13,"publisher":"The Royal Society","issue":"1198","license":[{"start":{"date-parts":[[1982,4,22]],"date-time":"1982-04-22T00:00:00Z","timestamp":388281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1982,4,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We present an analysis of experimental steady-state properties of charge movements in voltage-clamped frog skeletal muscle; by adopting an approach based on equilibrium statistical mechanics, detailed assumptions about the dynamics of the charge movement were avoided. Different components of the charge movements, as characterized by their sensitivities to local anaesthetics, were taken to correspond to different types of independent subsystem (integral membrane proteins). Quantitative agreement with the data for the q\u03b2 and q\u03b3 components was obtained for the simplest subsystems, having two energy levels; however, q\u03b1 required three (or more) energy levels. Each of the subsystems can be interpreted as having a charged group, minimum valency z, able to occupy two or more positions within the membrane. The tetracaine-sensitive q\u03b3 charge can be described in terms of an ensemble of subsystems having z = 4.5, each occupying one of two levels whose free energies at zero applied voltage differ by 1.7 x 10-1 eV. Likewise, the lidocaine-sensitive q\u03b2 has z = 1.0, free energy difference 1.9 x 10-2 eV. However, the simplest model for the lidocaine-resistant q\u03b1 involves a charge of valency 1.7 moving between three levels having relative free energies at zero applied voltage \u2014 9.7 x 10-2, 0, and 2.1 x 10-2 eV respectively, where the intermediate level \u2018 sees \u2019 about 50 % of the applied voltage.<\/jats:p>","DOI":"10.1098\/rspb.1982.0029","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T17:06:33Z","timestamp":1166202393000},"page":"75-94","source":"Crossref","is-referenced-by-count":4,"title":["A quantitative description of the voltage-dependent capacitance in frog skeletal muscle in terms of equilibrium statistical mechanics"],"prefix":"10.1098","volume":"215","author":[{"given":"S.","family":"Duane","sequence":"first","affiliation":[{"name":"New Hall, Cambridge CB3 0DF, U. K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. L. -h.","family":"Huang","sequence":"additional","affiliation":[{"name":"New Hall, Cambridge CB3 0DF, U. K., Physiological Laboratory, Cambridge CB2 3EG, U. K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Hume","family":"Adrian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bb.07.060178.000505"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011234"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1970.sp009139"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1979.sp012726"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012323"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0030498"},{"key":"p_7","doi-asserted-by":"crossref","unstructured":"Brillouin L. 1956 Science and information theory. New York: Academic Press.","DOI":"10.1063\/1.3059856"},{"key":"p_8","unstructured":"Hedvig P. 1970 Dielectric spectroscopy of polymers. Bristol: Adam Hilger."},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp009742"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013726"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013658"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014118"},{"key":"p_13","doi-asserted-by":"crossref","unstructured":"Landau L. D. & Lifshitz E. M. 1980 Statistical physics pt 1 (3rd edn). Oxford: Pergamon Press.","DOI":"10.1016\/B978-0-08-057046-4.50008-7"}],"container-title":["Proceedings of the Royal Society of London. Series B. Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rspb.1982.0029","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/rspb\/article-pdf\/215\/1198\/75\/172700\/rspb.1982.0029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rspb\/article-pdf\/215\/1198\/75\/172700\/rspb.1982.0029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T04:26:34Z","timestamp":1767500794000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rspb\/article\/215\/1198\/75\/33447\/A-quantitative-description-of-the-voltage"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,4,22]]},"references-count":13,"journal-issue":{"issue":"1198","published-print":{"date-parts":[[1982,4,22]]}},"URL":"https:\/\/doi.org\/10.1098\/rspb.1982.0029","relation":{},"ISSN":["0080-4649","2053-9193"],"issn-type":[{"value":"0080-4649","type":"print"},{"value":"2053-9193","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,4,22]]}}}