{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:31:30Z","timestamp":1790400690342,"version":"4.1.0"},"reference-count":56,"publisher":"The Royal Society","issue":"1231","license":[{"start":{"date-parts":[[1984,12,22]],"date-time":"1984-12-22T00:00:00Z","timestamp":472521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,12,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The retinogeniculate pathways of normal and albino ferrets have been studied with horseradish peroxidase and tritiated proline used as axonal markers. The uncrossed retinogeniculate projection of adult albino ferrets is abnormally small and occupies only a fraction of the geniculate area normally occupied by uncrossed afferents. The crossed pathway is correspondingly expanded, occupying almost the entire nucleus. The geniculate laminae in the albino ferret are abnormal, showing abnormal fusions between layers receiving crossed input and abnormal discontinuities next to the small cell islands receiving uncrossed afferents. In early development, retinofugal fibres can be labelled within the optic tracts on the 28th intrauterine day and a few crossed fibres can be traced into the lateral geniculate nucleus. At this stage, the uncrossed component is extremely small in normal and albino animals and cannot be traced beyond the tract. By day 32 retinal fibres are invading the lateral geniculate nucleus bilaterally, the invasion by the crossed component being significantly more advanced than that by the uncrossed component. The uncrossed pathway of the albinos is already abnormal in terms of its size, in terms of the position it occupies in the optic tract, and in terms of its limited invasion of the lateral geniculate nucleus. The abnormally reduced size of the uncrossed component appears earlier than the abnormal segregation of the retinogeniculate terminals, suggesting that the primary action of the albino gene upon central visual pathways is prechiasmatic. At postnatal stages (41 days after conception and older) the normal, gradual withdrawal of the uncrossed fibres from the monocular segment, and the separation of crossed from uncrossed retinogeniculate terminal arbors is significantly delayed in the albinos. The uncrossed retinogeniculate terminals are abnormally sparse initially and become distributed in an abnormal, interrupted pattern as development proceeds. The abnormal pattern of geniculate lamination appears to be secondary to the abnormal distribution of retinogeniculate afferents.<\/jats:p>","DOI":"10.1098\/rspb.1984.0087","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T17:06:33Z","timestamp":1166202393000},"page":"141-164","source":"Crossref","is-referenced-by-count":73,"title":["The development of the retinogeniculate pathways in normal and albino ferrets"],"prefix":"10.1098","volume":"223","author":[{"given":"Josephine","family":"Cucchiaro","sequence":"first","affiliation":[{"name":"Committee on Neurobiology and Department of Pharmacological and Physiological Sciences, The University of Chicago, 947 E 58th Street, Chicago, Illinois 60637, U. S. A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer Walter","family":"Guillery","sequence":"additional","affiliation":[{"name":"Committee on Neurobiology and Department of Pharmacological and Physiological Sciences, The University of Chicago, 947 E 58th Street, Chicago, Illinois 60637, U. S. A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","reference":[{"key":"p_1","doi-asserted-by":"crossref","unstructured":"Bunt S. M. Lund R. D. & Land P. W. 1983 Prenatal development of the optic projection in albino and hooded rats. D evi Brain Res. 6 149-168.","DOI":"10.1016\/0165-3806(83)90093-7"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.309179"},{"key":"p_3","first-page":"313","article-title":"The retinothalamic pathways in Siamese cats. comp","volume":"187","author":"Cooper M. L.","year":"1979","journal-title":"Neurol."},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1038\/231465a0"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.02-07-00907.1982"},{"key":"p_6","unstructured":"Cucchiaro J. 1984 The retinal origin and geniculate termination of the optic pathways of normal and albino ferrets: a developmental study. University of Chicago. Ph.D. thesis."},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1038\/296350a0"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90486-1"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(69)90213-3"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(71)90121-1"},{"key":"p_11","first-page":"44","article-title":"Visual pathways in albinos. Sci","volume":"230","author":"Guillery R.W.","year":"1974","journal-title":"Am."},{"key":"p_12","doi-asserted-by":"crossref","unstructured":"Guillery R.W. 1982 The optic chiasm of the vertebrate brain. Cont. sensory Physiol. 7 39-73.","DOI":"10.1016\/B978-0-12-151807-3.50008-2"},{"key":"p_13","first-page":"165","article-title":"Abnormal central visual pathways in the brain of an albino green monkey ( - pithecus aethiops). J. comp","volume":"226","author":"Guillery R. W.","year":"1984","journal-title":"Neurol."},{"key":"p_14","first-page":"73","article-title":"A study of normal and congenitally abnormal retinogeniculate projections in cats. J. comp","volume":"143","author":"Guillery R. W.","year":"1971","journal-title":"Neurol."},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1126\/science.180.4092.1287"},{"key":"p_16","first-page":"515","article-title":"A study of fine and coarse retino-fugal axons terminating in the geniculate C laminae and in the medial interlaminar nucleus of the mink. J. comp","volume":"176","author":"Guillery R. W.","year":"1977","journal-title":"Neurol."},{"key":"p_17","first-page":"623","article-title":"Abnormal retino-geniculate and geniculo-cortical pathways in several genetically distinct color phases of the mink ( vison). J.comp","volume":"185","author":"Guillery R. W.","year":"1979","journal-title":"Neurol."},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1126\/science.179.4077.1014"},{"key":"p_19","first-page":"239","article-title":"An autoradiographic study of retinogeniculate pathways in the cat and the fox. J.comp","volume":"156","author":"Hickey T. L.","year":"1974","journal-title":"Neurol."},{"key":"p_20","first-page":"815","article-title":"Neurogenesis of the cat's lateral geniculate nucleus: A 3H-thymidine study","volume":"8","author":"Hickey T. L.","year":"1982","journal-title":"Soc. Neurosci. Abstr."},{"key":"p_21","doi-asserted-by":"crossref","unstructured":"Hickey T. L. & Hitchcock P. F. 1984 Genesis of neurons in the geniculate nuclei of the cat. J. comp. Neurol. (In the press.)","DOI":"10.1002\/cne.902280205"},{"key":"p_22","first-page":"64","article-title":"The dorsal lateral geniculate nucleus (dLGN) of the normal ferret {Mustela putoriusfuro):A Golgi and electron microscopic analysis. Invest, ophthalmol. vis","volume":"24","author":"Ide L. S.","year":"1983","journal-title":"Sci."},{"key":"p_23","first-page":"815","article-title":"Genesis of different retinal ganglion cell types in the cat","volume":"8","author":"Kliot M.","year":"1982","journal-title":"Soc. Neurosci. Abstr."},{"key":"p_24","first-page":"141","article-title":"Differential reduction in the number of ipsilaterally projecting ganglion cells during the development of retinofugal projections in albino and pigmented rats","volume":"7","author":"Land P. W.","year":"1981","journal-title":"Soc. Neurosci. Abstr."},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.1126\/science.462177"},{"key":"p_26","unstructured":"Land P. W. Maxwell P. E. Eldridge J. T. Lund R. D. & Hargrove K. M. 1984 A comparison of retinogeniculate projections in albino and pigmented rats: early postnatal development. (In preparation.)"},{"key":"p_27","first-page":"399","article-title":"Genetic control of retinal ganglion cell projections. J. comp","volume":"182","author":"LaVail J. H.","year":"1978","journal-title":"Neurol."},{"key":"p_28","first-page":"227","article-title":"The projection of the visual world onto area 17 of the ferret","volume":"24","author":"Law M. I.","year":"1983","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"p_29","doi-asserted-by":"publisher","DOI":"10.1038\/300350a0"},{"key":"p_30","first-page":"189","article-title":"The dorsal lateral geniculate nucleus of the normal ferret and its postnatal development. J. comp","volume":"203","author":"Linden D. C.","year":"1981","journal-title":"Neurol."},{"key":"p_31","doi-asserted-by":"publisher","DOI":"10.1126\/science.149.3691.1506"},{"key":"p_32","first-page":"165A","article-title":"Development of retinogeniculate projections in albino and pigmented rats","volume":"199","author":"Maxwell P. E.","year":"1981","journal-title":"Anat. Rec."},{"key":"p_33","doi-asserted-by":"publisher","DOI":"10.1177\/26.2.24068"},{"key":"p_34","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(82)90125-0"},{"key":"p_35","first-page":"672","article-title":"Neurogenesis in cat retina. A study using 3H-thymidine autoradiography. Neurosci","volume":"7","author":"Polley E. H.","year":"1981","journal-title":"Abstr."},{"key":"p_36","unstructured":"Rogers A. W. 1979 Techniques of autoradiography. Amsterdam: Elsevier."},{"key":"p_37","first-page":"239","article-title":"Lamination of the dorsal lateral geniculate nucleus in carnivores of the weasel (Mustelidae), raccoon (Procyonidae) and Fox ( families. J. comp","volume":"153","author":"Sanderson K. J.","year":"1974","journal-title":"Neurol."},{"key":"p_38","first-page":"15","article-title":"Retinogeniculate projections in the rabbits of the albino allelomorphic series. J. comp","volume":"159","author":"Sanderson K. J.","year":"1975","journal-title":"Neurol."},{"key":"p_39","first-page":"225","article-title":"Congenitally abnormal visual pathways in mink {Mustela vison) with reduced pigment. J. comp","volume":"154","author":"Sanderson K. J.","year":"1974","journal-title":"Neurol."},{"key":"p_40","first-page":"205","article-title":"A comparison of visual pathways in Boston and Midwestern Siamese cats. J. comp","volume":"171","author":"Shatz C. J.","year":"1977","journal-title":"Neurol."},{"key":"p_41","first-page":"140","article-title":"Inside-out pattern of neurogenesis of the cat's lateral geniculate nucleus","volume":"7","author":"Shatz C. J.","year":"1981","journal-title":"Soc. Neurosci. Abstracts"},{"key":"p_42","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.03-03-00482.1983"},{"key":"p_43","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-05-01378.1984"},{"key":"p_44","doi-asserted-by":"publisher","DOI":"10.1038\/300525a0"},{"key":"p_45","first-page":"783","article-title":"The naso-temporal division of retina in the Siamese cat. J. comp","volume":"180","author":"Stone J.","year":"1978","journal-title":"Neurol."},{"key":"p_46","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(81)90034-1"},{"key":"p_47","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.01-11-01193.1981"},{"key":"p_48","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.03-10-01943.1983"},{"key":"p_49","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(81)90192-5"},{"key":"p_50","first-page":"198A","article-title":"The correlation between retinal ganglion cell production and organization of fibers in the cat's optic tract","volume":"202","author":"Walsh C.","year":"1982","journal-title":"Anat. Rec."},{"key":"p_51","doi-asserted-by":"publisher","DOI":"10.1038\/302611a0"},{"key":"p_52","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.03-01-00133.1983"},{"key":"p_53","first-page":"643","article-title":"Neurofibrillar development in the central nervous system of cat embryos between 8 and 12 mm long. J. comp","volume":"58","author":"Windle W. F.","year":"1933","journal-title":"Neurol."},{"key":"p_54","first-page":"139","article-title":"Neurofibrillar development of cat embryos: Extent of development in the telencephalon and diencephalon up to 15 mm. J. comp","volume":"63","author":"Windle W. F.","year":"1935","journal-title":"Neurol."},{"key":"p_55","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(76)90054-6"},{"key":"p_56","first-page":"207","article-title":"The projection of the visual field onto the lateral geniculate nucleus of the ferret","volume":"8","author":"Zahs K. R.","year":"1982","journal-title":"Soc. Neurosci. Abstr."}],"container-title":["Proceedings of the Royal Society of London. Series B. Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rspb.1984.0087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/rspb\/article-pdf\/223\/1231\/141\/173312\/rspb.1984.0087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rspb\/article-pdf\/223\/1231\/141\/173312\/rspb.1984.0087.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T04:42:28Z","timestamp":1767501748000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rspb\/article\/223\/1231\/141\/33692\/The-development-of-the-retinogeniculate-pathways"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,12,22]]},"references-count":56,"journal-issue":{"issue":"1231","published-print":{"date-parts":[[1984,12,22]]}},"URL":"https:\/\/doi.org\/10.1098\/rspb.1984.0087","relation":{},"ISSN":["0080-4649","2053-9193"],"issn-type":[{"value":"0080-4649","type":"print"},{"value":"2053-9193","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,12,22]]}}}