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Raising the [Na] from 1.4 to 31.4 mm revealed a sodium-sensitive fraction of net calcium exchange with a K1\/22 for Na+ ions of 12 mm, alongside the respiration-dependent accumulation of calcium. An acidosis, but not an alkalosis, was found to depress both of these processes. Mg2+ ions exerted an effect solely on the respiration-dependent calcium sequestration. A simple semi-empirical model based on the experimental data was formulated to assess the effects that altering sarcoplasmic [Na+] and [H+] would have on the calcium-handling properties of cardiac mitochondria. It is concluded that part of the inotropic effects of these ions could be mediated via this organelle.<\/jats:p>","DOI":"10.1098\/rspb.1984.0092","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T17:06:33Z","timestamp":1166202393000},"page":"239-254","source":"Crossref","is-referenced-by-count":15,"title":["The effects of sodium, hydrogen and magnesium ions on mitochondrial calcium sequestration in adult rat ventricular myocytes"],"prefix":"10.1098","volume":"223","author":[{"given":"C. H.","family":"Fry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Institute of Nuclear Medicine, Middlesex Hospital Medical School, London W1P 6DB, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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