{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:32:29Z","timestamp":1790695949659,"version":"4.1.0"},"reference-count":4,"publisher":"The Royal Society","issue":"1242","license":[{"start":{"date-parts":[[1985,10,22]],"date-time":"1985-10-22T00:00:00Z","timestamp":498787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,10,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The chromosome translocations characteristic of certain B lymphoid tumours associate the myc oncogene and immunoglobulin loci. The typical t(12;15) in murine plasmacytomas and analogous t(14;8) in Burkitt lyphomas couple themyc coding region to one of the switch recombination regions within the immunoglobulin heavy (H) chain locus; hence the switch machinery may promote some translocations. Significantly, translocation induces constitutive myc expression, the untranslocated myc allele remaining silent. The predilection for breakpoints near the 5\u00b4 end of the c -myc gene may reflect selection for altered myc regulation. In most tumours, the stimulatory effect of the H locus context is not understood, but an H locus enhancer participates in some tumours, including one displaying a novel transposition. The variant (6;15) translocations found in about 15 % of plasmacytomas involve the myc band and the region of chromosome 6 where the k locus lies. The t(6;15) is shown here to represent an exchange between CK and a chromosome 15 locus (designated pvt-1) which lies unexpectedly far from c-myc.The association of myc expression withpvt-1 alterations suggest that myc can be activated at a distance. Myc has also been implicated in some T lymphomas by detection of proviral inserts near myc and also surprisingly, within the pvt-1 locus. Inserts near myc appear to activate its expression via the retroviral enhancer.<\/jats:p>","DOI":"10.1098\/rspb.1985.0079","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T13:37:57Z","timestamp":1166189877000},"page":"59-72","source":"Crossref","is-referenced-by-count":20,"title":["<i>Myc<\/i>\n                    oncogene activation in B and T lymphoid tumours"],"prefix":"10.1098","volume":"226","author":[{"given":"J. M.","family":"Adams","sequence":"first","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Cory","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.22.6966"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.7.1982"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1126\/science.6414084"},{"key":"p_4","unstructured":"oncogene in B u rk itt Iym phom a."}],"container-title":["Proceedings of the Royal Society of London. Series B. Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rspb.1985.0079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/rspb\/article-pdf\/226\/1242\/59\/173560\/rspb.1985.0079.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rspb\/article-pdf\/226\/1242\/59\/173560\/rspb.1985.0079.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T04:48:30Z","timestamp":1767502110000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rspb\/article\/226\/1242\/59\/33784\/Myc-oncogene-activation-in-B-and-T-lymphoid"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,10,22]]},"references-count":4,"journal-issue":{"issue":"1242","published-print":{"date-parts":[[1985,10,22]]}},"URL":"https:\/\/doi.org\/10.1098\/rspb.1985.0079","relation":{},"ISSN":["0080-4649","2053-9193"],"issn-type":[{"value":"0080-4649","type":"print"},{"value":"2053-9193","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,10,22]]}}}