{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T04:52:34Z","timestamp":1767502354733,"version":"3.48.0"},"reference-count":24,"publisher":"The Royal Society","issue":"1246","license":[{"start":{"date-parts":[[1986,2,22]],"date-time":"1986-02-22T00:00:00Z","timestamp":509414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The effect of diets containing different types of common natural oils on physical properties of red cells was investigated by using rabbits. The rabbits were fed for 18 months on a standard diet in which 8% of its energy content was provided by safflower oil and 32% energy by either more safflower oil or fish oil, linseed oil, olive oil or palm oil. Erythrocyte deformability was significantly decreased by the fish oil diet compared with each of the other diets. Osmotic fragility was significantly less (66 mM) for red cells from rabbits fed on the linseed oil diet, and significantly greater (71 mM) for red cells from rabbits on the fish oil diet, than for red cells from rabbits on the other three diets which did not differ significantly from each other (68 mM). With rabbits on the standard diet, the resistance of their erythrocytes to osmotic haemolysis was increased by chlorpromazine at concentrations below and decreased by concentrations above 30 \u03bcM. The dietary oils caused significant changes in the effects of chlorpromazine on osmotic fragility. The concentration at which the effect of chlorpromazine reversed from antihaemolytic to prohaemolytic was decreased by the safflower and linseed oil diets and increased by the fish oil diet, compared with the olive and palm oil diets. Analysis of the fatty acid compositions of the dietary oils on the one hand and of the red cell phospholipids on the other established, specifically, that in the presence of 30 \u03bcM chlorpromazine the percentage haemolysis was directly proportional to the linoleate content of the red cell phospholipids.<\/jats:p>","DOI":"10.1098\/rspb.1986.0008","type":"journal-article","created":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T18:20:27Z","timestamp":1166466027000},"page":"43-51","source":"Crossref","is-referenced-by-count":10,"title":["Influence of dietary lipids on the effect of chlorpromazine on membrane properties of rabbit red cells"],"prefix":"10.1098","volume":"227","author":[{"given":"Georgina","family":"Housley","sequence":"first","affiliation":[{"name":"Department of Pharmacology, King's College, Strand, London WC2R 2LS, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustav Victor Rudolf","family":"Born","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, King's College, Strand, London WC2R 2LS, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolroes M.","family":"Conroy","sequence":"additional","affiliation":[{"name":"The Courtauld Institute of Biochemistry, Middlesex Hospital Medical School, London W1P 7PN, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Belin","sequence":"additional","affiliation":[{"name":"The Courtauld Institute of Biochemistry, Middlesex Hospital Medical School, London W1P 7PN, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony David","family":"Smith","sequence":"additional","affiliation":[{"name":"The Courtauld Institute of Biochemistry, Middlesex Hospital Medical School, London W1P 7PN, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1139\/y59-099"},{"key":"p_2","first-page":"67","article-title":"Membrane lipid fatty acids and regulation of membrane-bound enzymes. Allosteric behaviour of erythrocyte Mg 2+ATPase, (N++ K +) ATPase and acetylcholinesterase from rats fed different fat-supplemented diets. Biochim. biophys","volume":"311","author":"Bloj B.","year":"1973","journal-title":"Acta"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1983.tb11022.x"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1970.tb08492.x"},{"key":"p_5","first-page":"231","article-title":"Regulation of allosteric membrane-bound enzymes through changes in membrane lipid composition. Biochim. biophys","volume":"415","author":"Farias R. 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M. 1983 Dietary and enzymatic modifications of the effects of membrane-stabilizing drugs on the red cells of several species. Ph.D. thesis University of London."},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1983.0060"},{"key":"p_12","first-page":"124","article-title":"XH nuclear magnetic resonance study on transbilayer permeation of chlorpromazine in lecithin vesicles","volume":"20","author":"Kitamura K.","year":"1981","journal-title":"Molec. Pharmac."},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(84)90107-5"},{"key":"p_14","first-page":"144","article-title":"The influence of anaesthetics and cholesterol on the degree of molecular organization and mobility of ox brain white matter","volume":"12","author":"Neal M. J.","year":"1976","journal-title":"Molec. Pharmac."},{"key":"p_15","unstructured":"Nelson G. J. 1972 Lipid composition and metabolism of erythrocytes. In Blood lipids and lipoproteins: quantitation composition and metabolism (ed. G. J. Nelson) pp. 317-386. New"},{"key":"p_16","unstructured":"York: Wiley Interscience."},{"key":"p_17","first-page":"1","article-title":"Cholesterol modulates the effects on membrane perturbers in phospholipid vesicles and biomembranes. Biochim. biophys","volume":"511","author":"Pang K. Y. Y.","year":"1978","journal-title":"Acta"},{"key":"p_18","first-page":"583","article-title":"The membrane actions of anaesthetics and tranquillizers","volume":"24","author":"Seeman P.","year":"1972","journal-title":"Pharmac. Rev."},{"key":"p_19","first-page":"89","article-title":"The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. Biochim. biophys","volume":"779","author":"Stubbs C. 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