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The optical signals, recorded with millisecond time resolution, are good indicators of calcium-dependent electrical events. For many cells the sensitivity of the recordings was high enough to detect signals from each array element without averaging. Consequently, it was possible to use these signals to follow the complex spatial and temporal patterns of plateau and spike potentials. Calcium entry corresponding to action potentials was detected from all parts of the dendritic field including the fine spiny branchlets, demonstrating that calcium action potentials spread over the entire arbor. Usually, the entire dendritic tree fired at once. But sometimes only restricted areas had signals at any one moment with transients detected in different regions at other times. In one cell, six separate zones were distinguished. These results show that calcium action potentials could be regenerative in some dendrites and could fail to propagate into others. Signals from plateau potentials were also detec\u00adted from extensive areas in the dendritic field but were always smaller than those caused by a burst of action potentials.<\/jats:p>","DOI":"10.1098\/rspb.1990.0032","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T17:20:43Z","timestamp":1166203243000},"page":"173-185","source":"Crossref","is-referenced-by-count":24,"title":["Spatial and temporal analysis of calcium-dependent electrical activity in guinea pig Purkinje cell dendrites"],"prefix":"10.1098","volume":"240","author":[{"given":"William N.","family":"Ross","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nechama","family":"Lasser-Ross","sequence":"additional","affiliation":[{"name":"Department of Physiology, New York Medical College, Valhalla, New York 10595, U. S. A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Werman","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Hebrew University, Jersualem 91904, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(88)90025-5"},{"key":"p_2","first-page":"907","article-title":"Stoichiometry and apparent dissociation constant of the calcium-arsenazo III reaction under physiological conditions","volume":"32","author":"Ahmed Z.","year":"1980","journal-title":"Biophys."},{"key":"p_3","first-page":"143","article-title":"Calcium entry into voltage-clamped presynaptic terminals of squid. 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Loud."},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1968.31.2.131"},{"key":"p_11","first-page":"357","article-title":"Changes in the intracellular concentration of free calcium ions in a pace-maker neurone, measured with the metallochromic indicator dye arsenazo III. J . Physiol","volume":"275","author":"Gorman A. L. F.","year":"1978","journal-title":"Lond."},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.16.5565"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1981.45.5.829"},{"key":"p_14","unstructured":"Hamming R. W. 1977 Digital filters pp. 99-104. 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