{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:49:36Z","timestamp":1771051776602,"version":"3.50.1"},"reference-count":82,"publisher":"The Royal Society","issue":"1357","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proc. R. Soc. Lond. B"],"published-print":{"date-parts":[[1995,4,22]]},"DOI":"10.1098\/rspb.1995.0066","type":"journal-article","created":{"date-parts":[[2006,12,19]],"date-time":"2006-12-19T00:03:56Z","timestamp":1166486636000},"page":"105-111","source":"Crossref","is-referenced-by-count":39,"title":["Different calcium channels are coupled to potassium channels with distinct physiological roles in vagal neurons"],"prefix":"10.1098","volume":"260","member":"175","published-online":{"date-parts":[[1997,1]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(90)90135-3"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00580957"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.51.030189.002055"},{"key":"p_4","unstructured":"Blanton M. G. Lo Turco J. J. & Kriegstein A. R. 1989"},{"key":"p_5","unstructured":"etal. 1994) and is consistent Whole-cell recording from neurons in slices of reptilian and"},{"key":"p_6","unstructured":"with the close proximity of o>-CgTx binding sites and"},{"key":"p_7","unstructured":"putative transmitter release sites at the presynaptic"},{"key":"p_8","unstructured":"nerve terminal (Roberts mammalian cerebral cortex. J. Neurosci. Meth. 30 203-210."},{"key":"p_9","unstructured":"Castillo P. E. Weisskopf M. G. & Nicoll R. A. 1994 The"},{"key":"p_10","unstructured":"etal. 1990; Robitaille et al. role of C a++ channels in hippocampal mossy fibre synaptic transmission and long-term potentiation. Neuron 12"},{"key":"p_11","unstructured":"1990). However co-CgTx-sensitive calcium channels"},{"key":"p_12","unstructured":"261-269."},{"key":"p_13","unstructured":"are also expressed in the cell body of a variety of"},{"key":"p_14","unstructured":"neurons (Regan et al. 1991; Hoehn et al. 1993). The"},{"key":"p_15","unstructured":"results presented here demonstrate that these channels"},{"key":"p_16","unstructured":"play a key role in modulating the excitability of the cell"},{"key":"p_17","unstructured":"body by activating calcium-dependent potassium"},{"key":"p_18","unstructured":"currents generating the ahp. Interestingly CgTx"},{"key":"p_19","unstructured":"sensitive calcium channels appear to be colocalized"},{"key":"p_20","unstructured":"with BK-type calcium-activated potassium channels at"},{"key":"p_21","unstructured":"the presynaptic terminal (Roberts al. 1990;"},{"key":"p_22","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1989.61.1.218"},{"key":"p_23","doi-asserted-by":"publisher","DOI":"10.1038\/363455a0"},{"key":"p_24","unstructured":"Gola M. & Crest M. 1993 Colocalisation of active KCa"},{"key":"p_25","unstructured":"Robitaille etal. 1993) and in chick sensory neurons channels and Ca 2+ channels within Ca 2+ domains in helix"},{"key":"p_26","unstructured":"neurons. Neuron 10 689-699."},{"key":"p_27","unstructured":"(Wisgirda & Dryer 1994). One intriguing question is the anatomical"},{"key":"p_28","unstructured":"localization of the AHP channels. Binding studies"},{"key":"p_29","unstructured":"with antibodies generated against subunits of calcium"},{"key":"p_30","unstructured":"channels suggest that in central neurons L-type calcium"},{"key":"p_31","unstructured":"channels are clustered over the soma and proximal"},{"key":"p_32","unstructured":"dendrites whereas N-type channels are located in the"},{"key":"p_33","unstructured":"dendritic tree (Ahlijanian"},{"key":"p_34","doi-asserted-by":"publisher","DOI":"10.1038\/311538a0"},{"key":"p_35","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-03-01244.1993"},{"key":"p_36","unstructured":"etal.1990; Westenbroek^a\/. Lancaster B. & Nicoll R. A. 1987 Properties of two"},{"key":"p_37","unstructured":"1992). If a similar distribution also holds for dmv"},{"key":"p_38","unstructured":"neurons the ahp channels are likely to be located in"},{"key":"p_39","unstructured":"the dendritic tree. In conclusion these experiments show that two"},{"key":"p_40","unstructured":"pharmacologically distinct types of calcium channel"},{"key":"p_41","unstructured":"are activated during the action potential. These"},{"key":"p_42","unstructured":"calcium channels activate distinct sets of calcium"},{"key":"p_43","unstructured":"dependent potassium channels which play different"},{"key":"p_44","unstructured":"physiological roles in shaping the action potential and"},{"key":"p_45","unstructured":"the ahp. Calcium influx via CgTx-sensitive calcium"},{"key":"p_46","unstructured":"channels predominantly activates SK-type calcium"},{"key":"p_47","unstructured":"activated potassium currents which are responsible for"},{"key":"p_48","unstructured":"generating the slow ahp. Influx via CgTx-insensitive"},{"key":"p_49","unstructured":"channels predominantly activates BK-type calcium"},{"key":"p_50","unstructured":"activated potassium channels which contribute to"},{"key":"p_51","unstructured":"action potential repolarization. As calcium channels"},{"key":"p_52","unstructured":"can be modulated by several neurotransmitter systems"},{"key":"p_53","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016653"},{"key":"p_54","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016587"},{"key":"p_55","doi-asserted-by":"publisher","DOI":"10.1126\/science.3059497"},{"key":"p_56","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90090-8"},{"key":"p_57","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018331"},{"key":"p_58","doi-asserted-by":"publisher","DOI":"10.1126\/science.2432656"},{"key":"p_59","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90223-Z"},{"key":"p_60","unstructured":"Mintz I. M. Venema V. J. Swiderek K. Lee T. Bean B. P. & Adams M. P. 1992 bP-type calcium channels motor nucleus of the vagus in rat and guinea pig. J. Auton."},{"key":"p_61","unstructured":"blocked by the spider toxin (t>-Aga-IVA. Nature Lond. 355"},{"key":"p_62","unstructured":"827-829."},{"key":"p_63","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199312000-00039"},{"key":"p_64","doi-asserted-by":"publisher","DOI":"10.1126\/science.8388125"},{"key":"p_65","unstructured":"Randall etal. 1993 Five pharmacologically distinct high Storm J. F. 1987 Action potential repolarization and a fast voltage-activated C a2+ channels in cerebellar granule cells. Neurosci. 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