{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:33:14Z","timestamp":1789205594171,"version":"build-2803163510"},"reference-count":21,"publisher":"The Royal Society","issue":"1438","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proc. R. Soc. Lond. B"],"published-print":{"date-parts":[[2000,1,7]]},"DOI":"10.1098\/rspb.2000.0961","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T23:57:35Z","timestamp":1027727855000},"page":"23-29","source":"Crossref","is-referenced-by-count":33,"title":["Assessment of the prevalence of vCJD through testing tonsils and appendices for abnormal prion protein"],"prefix":"10.1098","volume":"267","author":[{"given":"Azra C","family":"Ghani","sequence":"first","affiliation":[{"name":"Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, South Parks Road, Oxford OX1 3FY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christl A","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, South Parks Road, Oxford OX1 3FY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, South Parks Road, Oxford OX1 3FY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy M","family":"Anderson","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, South Parks Road, Oxford OX1 3FY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2000,1,7]]},"reference":[{"key":"p_1","doi-asserted-by":"crossref","unstructured":"Anderson R. M. (and 14 others) 1996 Transmission dynamics and epidemiologyof BSE in British cattle. Nature 382 779^788.","DOI":"10.1038\/382779a0"},{"key":"p_2","doi-asserted-by":"crossref","unstructured":"Bruce M. E. (and 12 others) 1997 Transmissions to mice indicate that `new variant' CJD is caused by the BSE agent. Nature 389 498^501.","DOI":"10.1038\/39057"},{"key":"p_3","doi-asserted-by":"crossref","unstructured":"Collinge J. Palmer M. S. & Dryden A. J. 1991 Genetic predisposition to iatrogenic Creutzfeldt^Jakob disease. Lancet 337 1441^1442.","DOI":"10.1016\/0140-6736(91)93128-V"},{"key":"p_4","doi-asserted-by":"crossref","unstructured":"Collinge J. Sidle K. C. L. Meads J. Ironside J. & Hill A. F. 1996 Molecular analysis of prion strain variation and the aetiology of `new variant' CJD. Nature 383 685^690.","DOI":"10.1038\/383685a0"},{"key":"p_5","doi-asserted-by":"crossref","unstructured":"Efron B. & Tibshirani R. J. 1993 An introduction to the bootstrap. New York: Chapman & Hall.","DOI":"10.1007\/978-1-4899-4541-9"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-8-1891"},{"key":"p_7","doi-asserted-by":"crossref","unstructured":"Ghani A. C. Ferguson N. M. Donnelly C. A. Hagenaars T. J. & Anderson R. M. 1998a Epidemiological determinants of the pattern and magnitude of the vCJD epidemic in Great Britain. Proc. R. Soc. Lond. B 265 2443^2452.","DOI":"10.1098\/rspb.1998.0596"},{"key":"p_8","doi-asserted-by":"crossref","unstructured":"Ghani A. C. Ferguson N. M. Donnelly C. A. Hagenaars T. J. & Anderson R. M. 1998b Estimation of the number of people incubating variant CJD. Lancet 352 1353^1354.","DOI":"10.1016\/S0140-6736(05)60744-1"},{"key":"p_9","doi-asserted-by":"crossref","unstructured":"Hill A. F. Desbruslais M. Joiner S. Sidle K. C. L. Gowland I. Collinge J. Doey L. J. & Lantos P. 1997 The same prion strain causes vCJD and BSE. Nature 389 448^450.","DOI":"10.1038\/38925"},{"key":"p_10","doi-asserted-by":"crossref","unstructured":"Hill A. F. (and 14 others) 1999 Investigation of variant Creutzfeldt^Jakob disease and other human prion diseases with tonsil biopsy samples. Lancet 353 183^189.","DOI":"10.1016\/S0140-6736(98)12075-5"},{"key":"p_11","doi-asserted-by":"crossref","unstructured":"Hilton A. F. Fathers E. Edwards P. Ironside J. W. & Zajick J. 1998 Prion immunoreactivity in appendix before clinical onset of variant Creutzfeldt^Jakob disease. Lancet 352 703^704.","DOI":"10.1016\/S0140-6736(98)24035-9"},{"key":"p_12","doi-asserted-by":"crossref","unstructured":"McKay M. D. Beckman R. J. & Conover W. J. 1979 A comparison of three methods for selecting values on input variables in the analysis of output from a computer code. Technometrics 21 239^245.","DOI":"10.1080\/00401706.1979.10489755"},{"key":"p_13","unstructured":"Ministry of Agriculture Fisheries and Food 1996 Programme to eradicate BSE in the United Kingdom. London: HMSO."},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1136\/jech.48.6.590"},{"key":"p_15","article-title":"Codon 129 changes in the prion protein gene","volume":"46","author":"Owen F.","year":"1990","journal-title":"Am. J. Hum. Genet."},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/23.1.155"},{"key":"p_17","doi-asserted-by":"crossref","unstructured":"Ramberg J. S. Tadikamalia P. R. Dudewicz E. J. & Mykytka E. F. 1979 A probability distribution and its uses in \u00a2tting data.Technometrics 21 201^209.","DOI":"10.2307\/1268517"},{"key":"p_18","doi-asserted-by":"crossref","unstructured":"Schreuder B. E. C. Van Keulen L. J. M. Vromans M. E. W. Langeveld J. P. M. & Smits M. A. 1998 Tonsillar biopsy and PrP SC detection in the preclinical diagnosis of scrapie. Vet. Rec. 142 564^568.","DOI":"10.1136\/vr.142.21.564"},{"key":"p_19","doi-asserted-by":"crossref","unstructured":"Stein M. 1987 Large sample properties of simulations using Latin hypercube sampling.Technometrics 29 143^151.","DOI":"10.1080\/00401706.1987.10488205"},{"key":"p_20","doi-asserted-by":"crossref","unstructured":"Wells G. A. H. Hawkins S. A. C. Green R. B. Austin A. R. Dexter I. Spencer Y. I. Chaplin M. J. Stack M. J. & Dawson M. 1998 Preliminary observations on the pathogenesis of experimental bovine spongiform encephalopathy (BSE): an update.Vet. Rec. 142 103^106.","DOI":"10.1136\/vr.142.5.103"},{"key":"p_21","doi-asserted-by":"crossref","unstructured":"Will R. G. Ironside J. W. Zeidler M. Cousens S. N. Estibeiro K. Alperovitch A. Poser S. Pocchiari M. Hofman A. & Smith P. G. 1996 A new variant of Creutzfeldt^Jakob disease in the UK. Lancet 347 921^925.","DOI":"10.1016\/S0140-6736(96)91412-9"}],"container-title":["Proceedings of the Royal Society of London. Series B: Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rspb.2000.0961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T12:31:26Z","timestamp":1563539486000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rspb.2000.0961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1,7]]},"references-count":21,"journal-issue":{"issue":"1438","published-online":{"date-parts":[[2000,1,7]]},"published-print":{"date-parts":[[2000,1,7]]}},"alternative-id":["10.1098\/rspb.2000.0961"],"URL":"https:\/\/doi.org\/10.1098\/rspb.2000.0961","relation":{},"ISSN":["0962-8452","1471-2954"],"issn-type":[{"value":"0962-8452","type":"print"},{"value":"1471-2954","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1,7]]}}}