{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:03:56Z","timestamp":1791277436450,"version":"4.1.0"},"reference-count":34,"publisher":"The Royal Society","issue":"1695","license":[{"start":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T00:00:00Z","timestamp":1273017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Proc. R. Soc. B."],"published-print":{"date-parts":[[2010,9,22]]},"abstract":"<jats:p>\n            Q fever is a worldwide zoonosis caused by\n            <jats:italic>Coxiella burnetii<\/jats:italic>\n            . Although ruminants are recognized as the most important source of human infection, no previous studies have focused on assessing the characteristics of the bacterial spread within a cattle herd and no epidemic model has been proposed in this context. We assess the key epidemiological parameters from field data in a Bayesian framework that takes into account the available knowledge, missing data and the uncertainty of the observation process owing to the imperfection of diagnostic tests. We propose an original individual-based Markovian model in discrete time describing the evolution of the infection for each animal. Markov chain Monte Carlo methodology is used to estimate parameters of interest from data consisting of individual health states of 217 cows of five chronically infected dairy herds sampled every week for a four-week period. Outputs are the posterior distributions of the probabilities of transition between health states and of the environmental bacterial load. Our findings show that some herds are characterized by a very low infection risk while others have a mild infection risk and a non-negligible intermittent shedding probability. Moreover, the antibody status seems to be a key point in the bacterial spread (shedders with antibodies shed for a longer period of time than shedders without antibodies). In addition to the biological insights, these estimates also provide information for calibrating simulation models to assess control strategies for\n            <jats:italic>C. burnetii<\/jats:italic>\n            infection.\n          <\/jats:p>","DOI":"10.1098\/rspb.2010.0575","type":"journal-article","created":{"date-parts":[[2010,5,6]],"date-time":"2010-05-06T00:18:35Z","timestamp":1273105115000},"page":"2857-2865","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Spread of Q fever within dairy cattle herds: key parameters inferred using a Bayesian approach"],"prefix":"10.1098","volume":"277","author":[{"given":"Aur\u00e9lie","family":"Courcoul","sequence":"first","affiliation":[{"name":"INRA, BP 40706, 44307 Nantes, France"},{"name":"Oniris, UMR1300 Bio-agression, Epid\u00e9miologie et Analyse de Risque, BP 40706, 44307 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeta","family":"Vergu","sequence":"additional","affiliation":[{"name":"INRA, UR341 Math\u00e9matiques et Informatique Appliqu\u00e9es, 78350 Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Denis","sequence":"additional","affiliation":[{"name":"INRA, UR341 Math\u00e9matiques et Informatique Appliqu\u00e9es, 78350 Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Beaudeau","sequence":"additional","affiliation":[{"name":"INRA, BP 40706, 44307 Nantes, France"},{"name":"Oniris, UMR1300 Bio-agression, Epid\u00e9miologie et Analyse de Risque, BP 40706, 44307 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2010,5,5]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00140132"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.07.016"},{"key":"e_1_3_2_4_1","unstructured":"Anonymous. 2009 Centers for disease control and prevention . 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