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We analysed trabecular geometry in the femora of 90 terrestrial mammalian and avian species with body masses ranging from 3 g to 3400 kg. We found that bone volume fraction does not scale substantially with animal size, while trabeculae in larger animals' femora are thicker, further apart and fewer per unit volume than in smaller animals. Finite element modelling indicates that trabecular scaling does not alter the bulk stiffness of trabecular bone, but does alter strain within trabeculae under equal applied loads. Allometry of bone's trabecular tissue may contribute to the skeleton's ability to withstand load, without incurring the physiological or mechanical costs of increasing bone mass.<\/jats:p>","DOI":"10.1098\/rspb.2011.0069","type":"journal-article","created":{"date-parts":[[2011,3,9]],"date-time":"2011-03-09T10:30:49Z","timestamp":1299666649000},"page":"3067-3073","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":145,"title":["Trabecular bone scales allometrically in mammals and birds"],"prefix":"10.1098","volume":"278","author":[{"given":"Michael","family":"Doube","sequence":"first","affiliation":[{"name":"Department of Bioengineering, Imperial College London, South Kensington, London SW7 2AZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142 M.","family":"K\u0142osowski","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Imperial College London, South Kensington, London SW7 2AZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis M.","family":"Wiktorowicz-Conroy","sequence":"additional","affiliation":[{"name":"Structure and Motion Laboratory, The Royal Veterinary College, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Structure and Motion Laboratory, The Royal Veterinary College, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra J.","family":"Shefelbine","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Imperial College London, South Kensington, London SW7 2AZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2011,3,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01944490"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2000.19720145.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/283026"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7998.1979.tb03964.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7998.1979.tb03940.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1242\/jeb.105.1.147","article-title":"Allometry of quadrupedal locomotion: the scaling of duty factor, bone curvature and limb orientation to body size","volume":"105","author":"Biewener A. 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