{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:08:13Z","timestamp":1783487293547,"version":"3.55.0"},"reference-count":32,"publisher":"The Royal Society","issue":"1779","license":[{"start":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T00:00:00Z","timestamp":1395446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Proc. R. Soc. B."],"published-print":{"date-parts":[[2014,3,22]]},"abstract":"<jats:p>\n            The hormone thyroxine that regulates mammalian metabolism is carried and stored in the blood by thyroxine-binding globulin (TBG). We demonstrate here that the release of thyroxine from TBG occurs by a temperature-sensitive mechanism and show how this will provide a homoeostatic adjustment of the concentration of thyroxine to match metabolic needs, as with the hypothermia and torpor of small animals. In humans, a rise in temperature, as in infections, will trigger an accelerated release of thyroxine, resulting in a predictable 23% increase in the concentration of free thyroxine at 39\u00b0C. The\n            <jats:italic>in vivo<\/jats:italic>\n            relevance of this fever-response is affirmed in an environmental adaptation in aboriginal Australians. We show how two mutations incorporated in their TBG interact in a way that will halve the surge in thyroxine release, and hence the boost in metabolic rate that would otherwise occur as body temperatures exceed 37\u00b0C. The overall findings open insights into physiological changes that accompany variations in body temperature, as notably in fevers.\n          <\/jats:p>","DOI":"10.1098\/rspb.2013.2747","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T10:19:36Z","timestamp":1390990776000},"page":"20132747","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Temperature-responsive release of thyroxine and its environmental adaptation in Australians"],"prefix":"10.1098","volume":"281","author":[{"given":"Xiaoqiang","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust\/MRC Building, Hills Road, Cambridge CB2 0XY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wee Lee","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust\/MRC Building, Hills Road, Cambridge CB2 0XY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy J.","family":"Read","sequence":"additional","affiliation":[{"name":"Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust\/MRC Building, Hills Road, Cambridge CB2 0XY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiwu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust\/MRC Building, Hills Road, Cambridge CB2 0XY, UK"},{"name":"Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, School of Medicine, Shanghai JiaoTong University, No. 280, Shanghai 200025, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin W.","family":"Carrell","sequence":"additional","affiliation":[{"name":"Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust\/MRC Building, Hills Road, Cambridge CB2 0XY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2014,3,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0007"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.11.7049"},{"key":"e_1_3_3_4_2","unstructured":"Refetoff S. 2014 Thyroid hormone serum transport proteins: structure properties genes and transcriptional regulation. 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