{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:20:48Z","timestamp":1775305248130,"version":"3.50.1"},"reference-count":21,"publisher":"The Royal Society","issue":"1792","license":[{"start":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T00:00:00Z","timestamp":1412640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Proc. R. Soc. B."],"published-print":{"date-parts":[[2014,10,7]]},"abstract":"<jats:p>Inhalation of air-dispersed sub-micrometre and nano-sized particles presents a risk factor for animal and human health. Here, we show that nasal aerodynamics plays a pivotal role in the protection of the subterranean mole vole<jats:italic>Ellobius talpinus<\/jats:italic>from an increased exposure to nano-aerosols. Quantitative simulation of particle flow has shown that their deposition on the total surface of the nasal cavity is higher in the mole vole than in a terrestrial rodent<jats:italic>Mus musculus<\/jats:italic>(mouse), but lower on the olfactory epithelium. In agreement with simulation results, we found a reduced accumulation of manganese in olfactory bulbs of mole voles in comparison with mice after the inhalation of nano-sized MnCl<jats:sub>2<\/jats:sub>aerosols. We ruled out the possibility that this reduction is owing to a lower transportation from epithelium to brain in the mole vole as intranasal instillations of MnCl<jats:sub>2<\/jats:sub>solution and hydrated nanoparticles of manganese oxide MnO \u00b7 (H<jats:sub>2<\/jats:sub>O)<jats:italic><jats:sub>x<\/jats:sub><\/jats:italic>revealed similar uptake rates for both species. Together, we conclude that nasal geometry contributes to the protection of brain and lung from accumulation of air-dispersed particles in mole voles.<\/jats:p>","DOI":"10.1098\/rspb.2014.0919","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T09:36:12Z","timestamp":1408527372000},"page":"20140919","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Nasal aerodynamics protects brain and lung from inhaled dust in subterranean diggers,<i>Ellobius talpinus<\/i>"],"prefix":"10.1098","volume":"281","author":[{"given":"M. P.","family":"Moshkin","sequence":"first","affiliation":[{"name":"Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk 630090, Russia"},{"name":"Department of Physiology, Novosibirsk State University, Novosibirsk 630090, Russia"},{"name":"Department of Zoology and Animal Ecology, Tomsk State University, Tomsk 634050, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. V.","family":"Petrovski","sequence":"additional","affiliation":[{"name":"Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk 630090, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E.","family":"Akulov","sequence":"additional","affiliation":[{"name":"Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk 630090, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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