{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:10:08Z","timestamp":1790356208318,"version":"4.1.0"},"reference-count":44,"publisher":"The Royal Society","issue":"1852","license":[{"start":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T00:00:00Z","timestamp":1491350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100003426","name":"G\u00f6ran Gustafssons Stiftelse f\u00f6r Naturvetenskaplig och Medicinsk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"the Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the South African Medical Research Council"},{"name":"the Wenner-Gren Foundations"},{"name":"Erasmus Mundus Programme"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Proc. R. Soc. B."],"published-print":{"date-parts":[[2017,4,12]]},"abstract":"<jats:p>Genetic analyses can provide information about human evolutionary history that cannot always be gleaned from other sources. We evaluated evidence of selective pressure due to introduced infectious diseases in the genomes of two indigenous southern African San groups\u2014the \u2021Khomani who had abundant contact with other people migrating into the region and the more isolated Ju|\u2019hoansi. We used a dual approach to test for increased selection on immune genes compared with the rest of the genome in these groups. First, we calculated summary values of statistics that measure genomic signatures of adaptation to contrast selection signatures in immune genes and all genes. Second, we located regions of the genome with extreme values of three selection statistics and examined these regions for enrichment of immune genes. We found stronger and more abundant signals of selection in immune genes in the \u2021Khomani than in the Ju|\u2019hoansi. We confirm this finding within each population to avoid effects of different demographic histories of the two populations. We identified eight immune genes that have potentially been targets of strong selection in the \u2021Khomani, whereas in the Ju|\u2019hoansi, no immune genes were found in the genomic regions with the strongest signals of selection. We suggest that the more abundant signatures of selection at immune genes in the \u2021Khomani could be explained by their more frequent contact with immigrant groups, which likely led to increased exposure and adaptation to introduced infectious diseases.<\/jats:p>","DOI":"10.1098\/rspb.2017.0226","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T09:15:42Z","timestamp":1491383742000},"page":"20170226","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Adaptation to infectious disease exposure in indigenous Southern African populations"],"prefix":"10.1098","volume":"284","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5323-5079","authenticated-orcid":false,"given":"Katharine A.","family":"Owers","sequence":"first","affiliation":[{"name":"Department of Organismal Biology, Evolutionary Biology Centre, Uppsala University, Norbyv\u00e4gen 18C, 752 36 Uppsala, Sweden"},{"name":"Department of Epidemiology of Microbial Diseases, Yale University School of Public Health, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Sj\u00f6din","sequence":"additional","affiliation":[{"name":"Department of Organismal Biology, Evolutionary Biology Centre, Uppsala University, Norbyv\u00e4gen 18C, 752 36 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-9621","authenticated-orcid":false,"given":"Carina M.","family":"Schlebusch","sequence":"additional","affiliation":[{"name":"Department of Organismal Biology, Evolutionary Biology Centre, Uppsala University, Norbyv\u00e4gen 18C, 752 36 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-5913","authenticated-orcid":false,"given":"Pontus","family":"Skoglund","sequence":"additional","affiliation":[{"name":"Department of Organismal Biology, Evolutionary Biology Centre, Uppsala University, Norbyv\u00e4gen 18C, 752 36 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himla","family":"Soodyall","sequence":"additional","affiliation":[{"name":"Division of Human Genetics, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7840-7853","authenticated-orcid":false,"given":"Mattias","family":"Jakobsson","sequence":"additional","affiliation":[{"name":"Department of Organismal Biology, Evolutionary Biology Centre, Uppsala University, Norbyv\u00e4gen 18C, 752 36 Uppsala, Sweden"},{"name":"Science for Life Laboratory, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2017,4,5]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.an.22.100193.001421"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.2307\/1922166"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.02.041"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.03.027"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1313787111"},{"key":"e_1_3_7_7_2","first-page":"49","article-title":"Pastoral origins at the Cape, South Africa: influences and arguments","volume":"20","author":"Smith AB","year":"2008","journal-title":"South Afr. 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