{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:35:11Z","timestamp":1792794911252,"version":"4.5.0"},"reference-count":53,"publisher":"The Royal Society","issue":"1878","license":[{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["IOS 1256869"],"award-info":[{"award-number":["IOS 1256869"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union Seventh Framework Programme Marie Curie","award":["EACAA, grant agreement No 50."],"award-info":[{"award-number":["EACAA, grant agreement No 50."]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY024941"],"award-info":[{"award-number":["EY024941"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Proc. R. Soc. B."],"published-print":{"date-parts":[[2018,5,16]]},"abstract":"<jats:p>\n                    Multiple cave populations of the teleost\n                    <jats:italic>Astyanax mexicanus<\/jats:italic>\n                    have repeatedly reduced or lost eye and body pigmentation during adaptation to dark caves. Albinism, the complete absence of melanin pigmentation, is controlled by loss-of-function mutations in the\n                    <jats:italic>oca2<\/jats:italic>\n                    gene. The mutation is accompanied by an increase in the melanin synthesis precursor\n                    <jats:sc>l<\/jats:sc>\n                    -tyrosine, which is also a precursor for catecholamine synthesis. In this study, we show a relationship between pigmentation loss, enhanced catecholamine synthesis and responsiveness to anaesthesia, determined as a proxy for catecholamine-related behaviours. We demonstrate that anaesthesia resistance (AR) is enhanced in multiple depigmented and albino cavefish (CF), inversely proportional to the degree of pigmentation loss, controlled by the\n                    <jats:italic>oca2<\/jats:italic>\n                    gene, and can be modulated by experimental manipulations of\n                    <jats:sc>l<\/jats:sc>\n                    -tyrosine or the catecholamine norepinephrine (NE). Moreover, NE is increased in the brains of multiple albino and depigmented CF relative to surface fish. The results provide new insights into the evolution of pigment modification because NE controls a suite of adaptive behaviours similar to AR that may represent a target of natural selection. Thus, understanding the relationship between loss of pigmentation and AR may provide insight into the role of natural selection in the evolution of albinism via a melanin\u2013catecholamine trade-off.\n                  <\/jats:p>","DOI":"10.1098\/rspb.2018.0243","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T03:35:17Z","timestamp":1525232117000},"page":"20180243","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":46,"title":["Behavioural changes controlled by catecholaminergic systems explain recurrent loss of pigmentation in cavefish"],"prefix":"10.1098","volume":"285","author":[{"given":"Helena","family":"Biland\u017eija","sequence":"first","affiliation":[{"name":"Department of Biology, University of Maryland, College Park, MD 20742, USA"},{"name":"Department of Molecular Biology, Rudjer Boskovic Institute, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Maryland, College Park, MD 20742, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Maryland, College Park, MD 20742, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Renner","sequence":"additional","affiliation":[{"name":"Department of Biology, University of South Dakota, Vermillion, SD 57069, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6997-2946","authenticated-orcid":false,"given":"William R.","family":"Jeffery","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Maryland, College Park, MD 20742, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2018,5,2]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17471-2"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.24.110707.175302"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1139\/o2012-033"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.61"},{"key":"e_1_3_7_6_2","volume-title":"The biology of caves and other subterranean habitats","author":"Culver DC","year":"2009"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.0121"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24253"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802148-4.00008-6"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.01.051"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000326"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1700"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.25.12071"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1043-3_8"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2010.04759.x"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.adgen.2016.03.001"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-142X.2004.04026.x"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-142X.2012.00535.x"},{"key":"e_1_3_7_19_2","unstructured":"Biland\u017eija H Renner K \u0106etkovi\u0107 H Jeffery WR. 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