{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:37:52Z","timestamp":1790775472439,"version":"4.1.0"},"reference-count":51,"publisher":"The Royal Society","issue":"1894","license":[{"start":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100001961","name":"AXA research fund","doi-asserted-by":"crossref","award":["Pasteur-Cantarini postdoctoral fellowship"],"award-info":[{"award-number":["Pasteur-Cantarini postdoctoral fellowship"]}],"id":[{"id":"10.13039\/501100001961","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Proc. R. Soc. B."],"published-print":{"date-parts":[[2019,1,16]]},"abstract":"<jats:p>\n            Insecticide resistance has been reported to impact the interactions between mosquitoes and the pathogens they transmit. However, the effect on vector competence for arboviruses still remained to be investigated. We examined the influence of two insecticide resistance mechanisms on vector competence of the mosquito\n            <jats:italic>Culex quinquefasciatus<\/jats:italic>\n            for two arboviruses, Rift Valley Fever virus (RVFV) and West Nile virus (WNV). Three\n            <jats:italic>Cx. quinquefasciatus<\/jats:italic>\n            lines sharing a common genetic background were used: two insecticide-resistant lines, one homozygous for amplification of the\n            <jats:italic>\n              Ester\n              <jats:sup>2<\/jats:sup>\n            <\/jats:italic>\n            locus (SA2), the other homozygous for the acetylcholinesterase\n            <jats:italic>ace-1 G119S<\/jats:italic>\n            mutation (SR) and the insecticide-susceptible reference line Slab. Statistical analyses revealed no significant effect of insecticide-resistant mechanisms on vector competence for RVFV. However, both insecticide resistance mechanisms significantly influenced the outcome of WNV infections by increasing the dissemination of WNV in the mosquito body, therefore leading to an increase in transmission efficiency by resistant mosquitoes. These results showed that insecticide resistance mechanisms enhanced vector competence for WNV and may have a significant impact on transmission dynamics of arboviruses. Our findings highlight the importance of understanding the impacts of insecticide resistance on the vectorial capacity parameters to assess the overall consequence on transmission.\n          <\/jats:p>","DOI":"10.1098\/rspb.2018.2273","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T08:11:08Z","timestamp":1547626268000},"page":"20182273","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Insecticide resistance genes affect\n            <i>Culex quinquefasciatus<\/i>\n            vector competence for West Nile virus"],"prefix":"10.1098","volume":"286","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0233-2239","authenticated-orcid":true,"given":"C\u00e9lestine M.","family":"Atyame","sequence":"first","affiliation":[{"name":"Department of Virology, Institut Pasteur, Arboviruses and Insect Vectors, Paris, France"},{"name":"Universit\u00e9 de La R\u00e9union, UMR PIMIT (Processus Infectieux en Milieu Insulaire Tropical) CNRS-INSERM-IRD-Universit\u00e9 de La R\u00e9union, \u00eele de La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoues","family":"Alout","sequence":"additional","affiliation":[{"name":"INRA, UMR 1309 ASTRE, INRA-CIRAD, 34598 Montpellier, France"},{"name":"Institut des Sciences de l'Evolution de Montpellier (ISEM), UMR CNRS-IRD-EPHE-Universit\u00e9 de Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Mousson","sequence":"additional","affiliation":[{"name":"Department of Virology, Institut Pasteur, Arboviruses and Insect Vectors, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Vazeille","sequence":"additional","affiliation":[{"name":"Department of Virology, Institut Pasteur, Arboviruses and Insect Vectors, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mawlouth","family":"Diallo","sequence":"additional","affiliation":[{"name":"Institut Pasteur de Dakar, Unit\u00e9 d'Entomologie m\u00e9dicale, Dakar, S\u00e9n\u00e9gal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myl\u00e8ne","family":"Weill","sequence":"additional","affiliation":[{"name":"Institut des Sciences de l'Evolution de Montpellier (ISEM), UMR CNRS-IRD-EPHE-Universit\u00e9 de Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Bella","family":"Failloux","sequence":"additional","affiliation":[{"name":"Department of Virology, Institut Pasteur, Arboviruses and Insect Vectors, Paris, 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