{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:44:38Z","timestamp":1792676678001,"version":"4.5.0"},"reference-count":37,"publisher":"The Royal Society","issue":"1897","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["R01NS089609"],"award-info":[{"award-number":["R01NS089609"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["R21NS076176"],"award-info":[{"award-number":["R21NS076176"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Rochester Schmitt Program on Integrative Brain Research"},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"crossref","award":["F30EY027988"],"award-info":[{"award-number":["F30EY027988"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"crossref","award":["P30EY001319"],"award-info":[{"award-number":["P30EY001319"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Proc. R. Soc. B."],"published-print":{"date-parts":[[2019,2,27]]},"abstract":"<jats:p>Damage to the optic radiations or primary visual cortex leads to blindness in all or part of the contralesional visual field. Such damage disconnects the retina from its downstream targets and, over time, leads to trans-synaptic retrograde degeneration of retinal ganglion cells. To date, visual ability is the only predictor of retinal ganglion cell degeneration that has been investigated after geniculostriate damage. Given prior findings that some patients have preserved visual cortex activity for stimuli presented in their blind field, we tested whether that activity explains variability in retinal ganglion cell degeneration over and above visual ability. We prospectively studied 15 patients (four females, mean age = 63.7 years) with homonymous visual field defects secondary to stroke, 10 of whom were tested within the first two months after stroke. Each patient completed automated Humphrey visual field testing, retinotopic mapping with functional magnetic resonance imaging, and spectral-domain optical coherence tomography of the macula. There was a positive relation between ganglion cell complex (GCC) thickness in the blind field and early visual cortex activity for stimuli presented in the blind field. Furthermore, residual visual cortex activity for stimuli presented in the blind field soon after the stroke predicted the degree of retinal GCC thinning six months later. These findings indicate that retinal ganglion cell survival after ischaemic damage to the geniculostriate pathway is activity dependent.<\/jats:p>","DOI":"10.1098\/rspb.2018.2733","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T08:07:19Z","timestamp":1551254839000},"page":"20182733","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Survival of retinal ganglion cells after damage to the occipital lobe in humans is activity dependent"],"prefix":"10.1098","volume":"286","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3322-4468","authenticated-orcid":true,"given":"Colleen L.","family":"Schneider","sequence":"first","affiliation":[{"name":"Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA"},{"name":"Medical Scientist Training Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA"},{"name":"Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15206, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily K.","family":"Prentiss","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ania","family":"Busza","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Matmati","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rochester Regional Health, Rochester, NY 14621, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Matmati","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rochester Regional Health, Rochester, NY 14621, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zo\u00eb R.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA"},{"name":"Department of Ophthalmology, University of Rochester Medical Center, Rochester, NY 14642, USA"},{"name":"Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogachan","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford Z.","family":"Mahon","sequence":"additional","affiliation":[{"name":"Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15206, USA"},{"name":"Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA"},{"name":"Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA"},{"name":"Center for Visual Science, University of Rochester, Rochester, NY 14642, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(99)00097-8"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr125"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.26.5.402"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002210000384"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5708"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002841"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2016.12.010"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-014-2706-3"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097444"},{"key":"e_1_3_6_11_2","first-page":"33","article-title":"Patterns of recovery from homonymous hemianopia subsequent to infarction in the distribution of the posterior cerebral artery","volume":"11","author":"Tiel K","year":"1990","journal-title":"Neuro-Ophthalmology"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1317074111"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00308.2010"},{"key":"e_1_3_6_14_2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.47102\/annals-acadmedsg.V38N9p827","article-title":"Residual neurovascular function and retinotopy in a case of hemianopia","volume":"38","author":"Ho YC","year":"2009","journal-title":"Ann. Acad. Med. Singapore"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2008.20139"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968311407520"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-07-02619.1999"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0720"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1162\/089892904322984517"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000081776"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1050"},{"key":"e_1_3_6_22_2","first-page":"295","article-title":"The environment and disease: association or causation?","volume":"58","author":"Hill AB","year":"1965","journal-title":"Proc. R. Soc. Med."},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7886458"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19970315)47:6<561::AID-JNR1>3.0.CO;2-B"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.20.9444"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(95)00043-D"},{"key":"e_1_3_6_27_2","first-page":"3232","article-title":"Nerve growth factor promotes functional recovery of retinal ganglion cells after ischemia","volume":"34","author":"Siliprandi R","year":"1993","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3740"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19825"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1318"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005527"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.01.003"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003921"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7896"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7962"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.1167\/15.10.9"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.09-07-02353.1989"},{"key":"e_1_3_6_38_2","unstructured":"Gorgolewski KJ et al. 2016 The brain imaging data structure a format for organizing and describing outputs of neuroimaging experiments. Sci. Data 3 1-9. (doi:10.1038\/sdata.2016.44)"}],"container-title":["Proceedings of the Royal Society B: Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rspb.2018.2733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rspb.2018.2733","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rspb.2018.2733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T23:44:23Z","timestamp":1694648663000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rspb.2018.2733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,27]]},"references-count":37,"journal-issue":{"issue":"1897","published-print":{"date-parts":[[2019,2,27]]}},"alternative-id":["10.1098\/rspb.2018.2733"],"URL":"https:\/\/doi.org\/10.1098\/rspb.2018.2733","relation":{},"ISSN":["0962-8452","1471-2954"],"issn-type":[{"value":"0962-8452","type":"print"},{"value":"1471-2954","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,27]]},"assertion":[{"value":"2018-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}