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Recent proposals have focused on using<jats:italic>Z<\/jats:italic>-linked gene drives to control species with<jats:italic>ZW<\/jats:italic>sex determination, which include Lepidopteran pests, parasitic trematodes, and cane toads. These proposals include<jats:italic>Z<\/jats:italic>-linked \u2018<jats:italic>W<\/jats:italic>-shredders\u2019, which would suppress populations by cleaving the<jats:italic>W<\/jats:italic>chromosome and causing females to produce only sons, as well as<jats:italic>Z<\/jats:italic>-linked female-sterilizing gene drives. Here, I use eco-evolutionary simulations to evaluate the potential of some proposed<jats:italic>Z<\/jats:italic>-linked gene drives, and to produce recommendations regarding their design and use. The simulations show that<jats:italic>W<\/jats:italic>-shredders are likely to be highly effective at eradicating populations provided that resistance to<jats:italic>W<\/jats:italic>-shredding cannot evolve. However,<jats:italic>W<\/jats:italic>-shredder alleles can invade populations from very low frequencies, making it difficult to eliminate specific populations while leaving nearby populations untouched; this issue may restrict their possible uses.<\/jats:p>","DOI":"10.1098\/rspb.2019.1070","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T07:06:18Z","timestamp":1570604778000},"page":"20191070","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Evolutionary simulations of<i>Z<\/i>-linked suppression gene drives"],"prefix":"10.1098","volume":"286","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7268-2173","authenticated-orcid":true,"given":"Luke","family":"Holman","sequence":"first","affiliation":[{"name":"School of BioSciences, The University of Melbourne, Melbourne, Victoria 3010, 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