{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T01:34:49Z","timestamp":1772156089681,"version":"3.50.1"},"reference-count":47,"publisher":"The Royal Society","issue":"1925","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/-\/media\/journals\/author\/Licence-to-Publish-20062019-final.pdf"},{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["Discovery grant"],"award-info":[{"award-number":["Discovery grant"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Proc. R. Soc. B."],"published-print":{"date-parts":[[2020,4,29]]},"abstract":"<jats:p>\n                    Parasites with complex life cycles have been proposed to manipulate the behaviour of their intermediate hosts to increase the probability of reaching their final host. The cause of these drastic behavioural changes could be manipulation factors released by the parasite in its environment (the secretome), but this has rarely been assessed. We studied a non-cerebral parasite, the cestode\n                    <jats:italic>Schistocephalus solidus<\/jats:italic>\n                    , and its intermediate host, the threespine stickleback (\n                    <jats:italic>Gasterosteus aculeatus<\/jats:italic>\n                    ), whose response to danger becomes significantly diminished when infected. These altered behaviours appear only during late infection, when the worm is ready to reproduce in its final avian host. Sympatric host\u2013parasite pairs show higher infection success for parasites, suggesting that the secretome effects could differ for allopatric host\u2013parasite pairs with independent evolutionary histories. We tested the effects of secretome exposure on behaviour by using secretions from the early and late infection of\n                    <jats:italic>S. solidus<\/jats:italic>\n                    and by injecting them in healthy sticklebacks from a sympatric and allopatric population. Contrary to our prediction, secretome from late infection worms did not result in more risky behaviours, but secretome from early infection resulted in more cautious hosts, only in fish from the allopatric population. Our results suggest that the secretome of\n                    <jats:italic>S. solidus<\/jats:italic>\n                    contains molecules that can affect host behaviour, that the causes underlying the behavioural changes in infected sticklebacks are multifactorial and that local adaptation between host\u2013parasite pairs may extend to the response to the parasite's secretome content.\n                  <\/jats:p>","DOI":"10.1098\/rspb.2020.0412","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T02:32:14Z","timestamp":1586917934000},"page":"20200412","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["The secretome of a parasite alters its host's behaviour but does not recapitulate the behavioural response to infection"],"prefix":"10.1098","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8375-2931","authenticated-orcid":true,"given":"Chlo\u00e9 Suzanne","family":"Berger","sequence":"first","affiliation":[{"name":"D\u00e9partement de Biologie and Institut de Biologie Int\u00e9grative et des Syst\u00e8mes (IBIS), Universit\u00e9 Laval, Qu\u00e9bec, Quebec, Canada G1V 0A6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9030-634X","authenticated-orcid":true,"given":"Nadia","family":"Aubin-Horth","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biologie and Institut de Biologie Int\u00e9grative et des Syst\u00e8mes (IBIS), Universit\u00e9 Laval, Qu\u00e9bec, Quebec, Canada G1V 0A6"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2001)087[0267:PIVIHM]2.0.CO;2"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1645\/GE-758R.1"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.1.288-296.2001"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/jipa.1993.1003"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.073668"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.073825"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-018-2805-9"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004289"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(95)00103-4"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2015.06.009"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2014.03.007"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2009.04.008"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cois.2019.01.004"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)00605-2"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182097001406"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.2011.01330.x"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000066609"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182012001266"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2013.09.004"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.2307\/3283228"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2007.1148"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1163\/1568539042948231"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/mec.13970"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.1995.tb01919.x"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.174748"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-3472(83)80025-6"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.151456"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2001.1668"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2013.08.029"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/ivb.12202"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000031206"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2017.03.004"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1419-3"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1086\/689597"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.1645\/14-701"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.1645\/GE-2968.1"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1515\/ohs-2015-0002"},{"key":"e_1_3_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2013.10.019"},{"key":"e_1_3_7_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12862-014-0166-3"},{"key":"e_1_3_7_41_2","first-page":"2417","article-title":"Variation between populations and local adaptation in acanthocephalan-induced parasite manipulation","volume":"64","author":"Franceschi N","year":"2010","journal-title":"Evolution"},{"key":"e_1_3_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2015.10.001"},{"key":"e_1_3_7_43_2","doi-asserted-by":"publisher","DOI":"10.1139\/z89-003"},{"key":"e_1_3_7_44_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.178137"},{"key":"e_1_3_7_45_2","volume-title":"R: a language and environment for statistical computing","author":"R Core Team.","year":"2018"},{"key":"e_1_3_7_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00265-017-2265-9"},{"key":"e_1_3_7_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/eth.12808"},{"key":"e_1_3_7_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12862-019-1406-3"}],"container-title":["Proceedings of the Royal Society B: Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rspb.2020.0412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rspb.2020.0412","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rspb.2020.0412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T02:15:50Z","timestamp":1613614550000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rspb.2020.0412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,15]]},"references-count":47,"journal-issue":{"issue":"1925","published-print":{"date-parts":[[2020,4,29]]}},"alternative-id":["10.1098\/rspb.2020.0412"],"URL":"https:\/\/doi.org\/10.1098\/rspb.2020.0412","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/799551","asserted-by":"object"}]},"ISSN":["0962-8452","1471-2954"],"issn-type":[{"value":"0962-8452","type":"print"},{"value":"1471-2954","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,15]]},"assertion":[{"value":"2020-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}