{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:57:13Z","timestamp":1792688233724,"version":"4.5.0"},"reference-count":36,"publisher":"The Royal Society","issue":"1928","license":[{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"crossref","award":["2016-0146"],"award-info":[{"award-number":["2016-0146"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008183","name":"Central Manchester University Hospitals NHS Foundation Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008183","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001388","name":"Wenner-Gren Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001388","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Proc. R. Soc. B."],"published-print":{"date-parts":[[2020,6,10]]},"abstract":"<jats:p>Mate choice can continue after mating via chemical communication between the female reproductive system and sperm. While there is a growing appreciation that females can bias sperm use and paternity by exerting cryptic female choice for preferred males, we know surprisingly little about the mechanisms underlying these post-mating choices. In particular, whether chemical signals released from eggs (chemoattractants) allow females to exert cryptic female choice to favour sperm from specific males remains an open question, particularly in species (including humans) where adults exercise pre-mating mate choice. Here, we adapt a classic dichotomous mate choice assay to the microscopic scale to assess gamete-mediated mate choice in humans. We examined how sperm respond to follicular fluid, a source of human sperm chemoattractants, from either their partner or a non-partner female when experiencing a simultaneous or non-simultaneous choice between follicular fluids. We report robust evidence under these two distinct experimental conditions that follicular fluid from different females consistently and differentially attracts sperm from specific males. This chemoattractant-moderated choice of sperm offers eggs an avenue to exercise independent mate preference. Indeed, gamete-mediated mate choice did not reinforce pre-mating human mate choice decisions. Our results demonstrate that chemoattractants facilitate gamete-mediated mate choice in humans, which offers females the opportunity to exert cryptic female choice for sperm from specific males.<\/jats:p>","DOI":"10.1098\/rspb.2020.0805","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T03:05:44Z","timestamp":1591758344000},"page":"20200805","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":47,"title":["Chemical signals from eggs facilitate cryptic female choice in humans"],"prefix":"10.1098","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2834-4409","authenticated-orcid":true,"given":"John L.","family":"Fitzpatrick","sequence":"first","affiliation":[{"name":"Department of Zoology, Stockholm University, Svante Arrhenius v\u00e4g 18B, 10691 Stockholm, Sweden"},{"name":"Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Willis","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8104-5195","authenticated-orcid":true,"given":"Alessandro","family":"Devigili","sequence":"additional","affiliation":[{"name":"Department of Zoology, Stockholm University, Svante Arrhenius v\u00e4g 18B, 10691 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Young","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester M1 5GD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen R.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Saint Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, Oxford Road, Manchester M13 9WL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Brison","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK"},{"name":"Department of Reproductive Medicine, Saint Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, Oxford Road, Manchester M13 9WL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1515\/9780691207278"},{"key":"e_1_3_6_3_2","volume-title":"Mate choice: the evolution of sexual decision making from microbes to humans","author":"Rosenthal GG","year":"2017"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2004.07.018"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-294x.2000.00964.x"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1893"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2012.0181"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2018.0836"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0304594101"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018666108"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2017.02.010"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/jeb.13194"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/ele.12471"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.02.007"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(02)00090-8"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12452"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.7.2840"},{"key":"e_1_3_6_18_2","volume-title":"WHO laboratory manual for the examination and processing of human semen","author":"World Health Organization","year":"2010","edition":"5"},{"key":"e_1_3_6_19_2","unstructured":"World Health Organization. 2005 Handbook for good clinical research practice (GCP): guidance for implementation. Geneva Switzerland: World Health Organization. See https:\/\/apps.who.int\/iris\/handle\/10665\/43392."},{"key":"e_1_3_6_20_2","unstructured":"Human Fertilisation and Embryo Authority. 2017 Code of practice 8th edn. London UK: Human Fertilisation and Embryo Authority. See https:\/\/www.hfea.gov.uk\/media\/2062\/2017-10-02-code-of-practice-8thedition-full-version-11th-revision-final-clean.pdf."},{"key":"e_1_3_6_21_2","volume-title":"Genetics and analysis of quantitative traits","author":"Lynch M","year":"1998"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1530\/ror.0.0040056"},{"key":"e_1_3_6_23_2","volume-title":"RStudio: integrated development for R.","author":"R Team.","year":"2018"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_3_6_25_2","unstructured":"Herve M. 2018 Testing and plotting procedures for biostatistics. Package RVAideMemoire. See https:\/\/cran.r-project.org\/web\/packages\/RVAideMemoire\/RVAideMemoire.pdf."},{"key":"e_1_3_6_26_2","unstructured":"Hartig F. 2020 DHARMa: residual diagnostics for hierarchical (multi-level\/mixed) regression models. R package version 0.1.5. See https:\/\/CRAN.R-project.org\/package=DHARMa."},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1530\/REP-12-0285"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137975"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012311629-1\/50005-X"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2014.0148"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1995.0087"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000925"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2017.1830"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/mec.13920"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000184"},{"key":"e_1_3_6_36_2","unstructured":"Human Fertilisation and Embryo Authority 2017 Fertility treatment 2014\u20132016: trends and figures. London UK: Human Fertilisation and Embryo Authority. See https:\/\/www.hfea.gov.uk\/media.2563\/hfea-fertility-trends-and-figures-2017-v2.pdf."},{"key":"e_1_3_6_37_2","unstructured":"Fitzpatrick JL Willis C Devigili A Young A Carroll M Hunter HR Brison DR. 2020 Data from: Chemical signals from eggs facilitate cryptic female choice in humans. Dryad Digital Repository. (doi:10.5061\/dryad.wdbrv15kb)"}],"container-title":["Proceedings of the Royal Society B: Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rspb.2020.0805","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rspb.2020.0805","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rspb.2020.0805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T02:27:51Z","timestamp":1613615271000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rspb.2020.0805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,10]]},"references-count":36,"journal-issue":{"issue":"1928","published-print":{"date-parts":[[2020,6,10]]}},"alternative-id":["10.1098\/rspb.2020.0805"],"URL":"https:\/\/doi.org\/10.1098\/rspb.2020.0805","relation":{},"ISSN":["0962-8452","1471-2954"],"issn-type":[{"value":"0962-8452","type":"print"},{"value":"1471-2954","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,10]]},"assertion":[{"value":"2020-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}