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B."],"published-print":{"date-parts":[[2022,11,30]]},"abstract":"<jats:p>\n            Behaviour and physiology are altered in reproducing animals, but neuronal circuits that regulate these changes remain largely unknown. Insights into mechanisms that regulate and possibly coordinate reproduction-related traits could be gleaned from the study of sex pheromones that can improve the reproductive success of potential mating partners. In\n            <jats:italic>Caenorhabditis elegans<\/jats:italic>\n            , the prominent male pheromone, ascr#10, modifies reproductive behaviour and several aspects of reproductive physiology in hermaphrodite recipients, including improving oocyte quality. Here we show that a circuit that contains serotonin-producing and serotonin-uptaking neurons plays a key role in mediating effects of ascr#10 on germline development and egg laying behaviour. We also demonstrate that increased serotonin signalling promotes proliferation of germline progenitors in adult hermaphrodites. Our results establish a role for serotonin in maintaining germline quality and highlight a simple neuronal circuit that acts as a linchpin that couples food intake, mating behaviour, reproductive output, and germline renewal and provisioning.\n          <\/jats:p>","DOI":"10.1098\/rspb.2022.0913","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T08:09:56Z","timestamp":1669795796000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["The serotonin circuit that coordinates germline proliferation and egg laying with other reproductive functions in\n            <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1098","volume":"289","author":[{"given":"Erin Z.","family":"Aprison","sequence":"first","affiliation":[{"name":"Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Dzitoyeva","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8318-3679","authenticated-orcid":true,"given":"Ilya","family":"Ruvinsky","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781139030748"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb300169c"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.10.012"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0040-5809(76)90040-X"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005729"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2015576119"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.119.300238"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.08.024"},{"key":"e_1_3_6_10_2","unstructured":"Aprison EZ Ruvinsky I. 2022 The roles of several sensory neurons and the feedback from egg laying in regulating the germline response to a sex pheromone in C. elegans hermaphrodites. 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