{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:47:56Z","timestamp":1787010476547,"version":"build-2736575974"},"reference-count":75,"publisher":"The Royal Society","issue":"1990","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"name":"National Science and Technology Council, Taiwan","award":["MOST 111-2621-M-019-003"],"award-info":[{"award-number":["MOST 111-2621-M-019-003"]}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Proc. R. Soc. B."],"published-print":{"date-parts":[[2023,1,11]]},"abstract":"<jats:p>\n                    The shallow-water hydrothermal vent system of Kueishan Island has been described as one of the world's most acidic and sulfide-rich marine habitats. The only recorded metazoan species living in the direct vicinity of the vents is\n                    <jats:italic>Xenograpsus testudinatus,<\/jats:italic>\n                    a brachyuran crab endemic to marine sulfide-rich vent systems. Despite the toxicity of hydrogen sulfide,\n                    <jats:italic>X. testudinatus<\/jats:italic>\n                    occupies an ecological niche in a sulfide-rich habitat, with the underlying detoxification mechanism remaining unknown. Using laboratory and field-based experiments, we characterized the gills of\n                    <jats:italic>X. testudinatus<\/jats:italic>\n                    that are the major site of sulfide detoxification. Here sulfide is oxidized to thiosulfate or bound to hypotaurine to generate the less toxic thiotaurine. Biochemical and molecular analyses demonstrated that the accumulation of thiosulfate and hypotaurine is mediated by the sodium-independent sulfate anion transporter (SLC26A11) and taurine transporter (Taut), which are expressed in gill epithelia. Histological and metagenomic analyses of gill tissues demonstrated a distinct bacterial signature dominated by\n                    <jats:italic>Epsilonproteobacteria<\/jats:italic>\n                    . Our results suggest that thiotaurine synthesized in gills is used by sulfide-oxidizing endo-symbiotic bacteria, creating an effective sulfide-buffering system. This work identified physiological mechanisms involving host-microbe interactions that support life of a metazoan in one of the most extreme environments on our planet.\n                  <\/jats:p>","DOI":"10.1098\/rspb.2022.1973","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T06:24:49Z","timestamp":1673418289000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Cellular mechanisms underlying extraordinary sulfide tolerance in a crustacean holobiont from hydrothermal vents"],"prefix":"10.1098","volume":"290","author":[{"given":"Pei-Hsuan","family":"Chou","sequence":"first","affiliation":[{"name":"Marine Research Station (MRS), Institute of Cellular and Organismic Biology, Academia Sinica, I-Lan County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian Y.","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Physiology, 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