{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:42:23Z","timestamp":1790772143558,"version":"4.1.0"},"reference-count":65,"publisher":"The Royal Society","issue":"1997","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"crossref","award":["BB\/V019945\/1"],"award-info":[{"award-number":["BB\/V019945\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Italian Ministry of Health","award":["RC-IZSVe-6\/19"],"award-info":[{"award-number":["RC-IZSVe-6\/19"]}]},{"name":"The Italian Ministry of Health","award":["RC-IZSVe-8\/18"],"award-info":[{"award-number":["RC-IZSVe-8\/18"]}]},{"name":"The Italian Ministry of Health","award":["WFR GR-2011-023505919"],"award-info":[{"award-number":["WFR GR-2011-023505919"]}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Proc. R. Soc. B."],"published-print":{"date-parts":[[2023,4,26]]},"abstract":"<jats:p>\n                    We investigated the transmission dynamics of lyssavirus in\n                    <jats:italic>Myotis myotis<\/jats:italic>\n                    and\n                    <jats:italic>Myotis blythii<\/jats:italic>\n                    , using serological, virological, demographic and ecological data collected between 2015 and 2022 from two maternity colonies in northern Italian churches. Despite no lyssavirus detection in 556 bats sampled over 11 events by reverse transcription-polymerase chain reaction (RT-PCR), 36.3% of 837 bats sampled over 27 events showed neutralizing antibodies to\n                    <jats:italic>European bat lyssavirus 1<\/jats:italic>\n                    , with a significant increase in summers. By fitting sets of mechanistic models to seroprevalence data, we investigated factors that influenced lyssavirus transmission within and between years. Five models were selected as a group of final models: in one model, a proportion of exposed bats (median model estimate: 5.8%) became infectious and died while the other exposed bats recovered with immunity without becoming infectious; in the other four models, all exposed bats became infectious and recovered with immunity. The final models supported that the two colonies experienced seasonal outbreaks driven by: (i) immunity loss particularly during hibernation, (ii) density-dependent transmission, and (iii) a high transmission rate after synchronous birthing. These findings highlight the importance of understanding ecological factors, including colony size and synchronous birthing timing, and potential infection heterogeneities to enable more robust assessments of lyssavirus spillover risk.\n                  <\/jats:p>","DOI":"10.1098\/rspb.2023.0183","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T19:05:25Z","timestamp":1681844725000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Transmission dynamics of lyssavirus in\n                    <i>Myotis myotis<\/i>\n                    : mechanistic modelling study based on longitudinal seroprevalence data"],"prefix":"10.1098","volume":"290","author":[{"given":"Younjung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Evolution, Behaviour, and Environment, School of Life Sciences, University of Sussex, BN1 9RH Brighton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Leopardi","sequence":"additional","affiliation":[{"name":"FAO and National Reference Centre for Rabies, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Universit\u00e0 10, Legnaro, 35020 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dino","family":"Scaravelli","sequence":"additional","affiliation":[{"name":"S.T.E.R.N.A. and Museo Ornitologico \u2018F. 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