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R. Soc. B."],"published-print":{"date-parts":[[2023,11,29]]},"abstract":"<jats:p>\n                    The attraction of anthropophilic mosquitoes to human host cues, such as body odour and carbon dioxide, gradually increases during adult maturation. This acquisition of host-seeking behaviour correlates with age-dependent changes in odorant receptor (OR) transcript abundance and sensitivity of olfactory sensory neurons (OSNs). One OR gene of the human malaria vector,\n                    <jats:italic>Anopheles coluzzii<\/jats:italic>\n                    ,\n                    <jats:italic>AcolOR39<\/jats:italic>\n                    , is significantly downregulated in mature females, and a cognate ligand of AcolOR39, sulcatone, a major component of human emanations, mediates the observed behavioural inhibition of newly emerged (teneral) females to human body odour. Knockout of\n                    <jats:italic>AcolOR39<\/jats:italic>\n                    , using CRISPR\u2013Cas9 mutagenesis, selectively abolished sulcatone detection in OSNs, housed in trichoid sensilla. However, knockout of\n                    <jats:italic>AcolOR39<\/jats:italic>\n                    altered neither the response rate nor the flight behaviour of teneral females in a wind tunnel, indicating the involvement of other genes, and thus a redundancy, in regulating the acquisition of host seeking in mosquitoes.\n                  <\/jats:p>","DOI":"10.1098\/rspb.2023.2092","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T03:11:33Z","timestamp":1701227493000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Knockout of OR39 reveals redundancy in the olfactory pathway regulating the acquisition of host seeking in\n                    <i>Anopheles coluzzii<\/i>"],"prefix":"10.1098","volume":"290","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7907-3514","authenticated-orcid":true,"given":"Annika","family":"Hinze","sequence":"first","affiliation":[{"name":"Disease Vector Group, Unit of Chemical Ecology, Department of Plant Protection Biology, Swedish University of Agricultural Sciences, Alnarp 750 07, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Disease Vector Group, Unit of Chemical Ecology, Department of Plant Protection Biology, Swedish University of Agricultural Sciences, Alnarp 750 07, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Ghaninia","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Arizona State University, Tempe, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Marois","sequence":"additional","affiliation":[{"name":"Inserm, CNRS, Universit\u00e9 de Strasbourg, Strasbourg 67070, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon Rose","family":"Hill","sequence":"additional","affiliation":[{"name":"Disease Vector Group, Unit of Chemical Ecology, Department of Plant Protection Biology, Swedish University of Agricultural Sciences, Alnarp 750 07, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-5986","authenticated-orcid":true,"given":"Rickard","family":"Ignell","sequence":"additional","affiliation":[{"name":"Disease Vector Group, Unit of Chemical Ecology, Department of Plant Protection Biology, Swedish University of Agricultural Sciences, Alnarp 750 07, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-3472(72)80040-X"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511610493"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.178905"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4922(01)02116-X"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1079\/9780851993133.0000"},{"key":"e_1_3_8_7_2","first-page":"212","volume-title":"In Ciba Foundation Symposium 200: olfaction in mosquito\u2013host interaction","author":"Klowden MJ","year":"2007","unstructured":"Klowden MJ. 2007 Endogenous factors regulating mosquito host-seeking behaviour. 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